1. SBU 1013 WORLD OF CELL
SEMESTER 2 SESSION 2017/2018
ASSIGNMENT: ARTICLE REVIEWFORM
Name: Fadhullah bin Abd Ghani
Student ID: E20172019117
Article No. : 5
1. Full Bibliographic Reference
State the full bibliographic reference of the article you are reviewing
(authors, title, journal name, volume, issue, year, page numbers)
1) Who is/are the author(s) of the
article?
S. J. Singer and Garth L. Nicolson
2) What is the title of the article? The Fluid Mosaic Model of the
Structure of Cell Membranes
3) What is the name of the article? The Fluid Mosaic Model of the
Structure of Cell Membranes
4) What is the volume number of
the article? If any
1) Thermodynamics and
Membrane Structure
2) The Fluid Mosaic Model and
Membrane Functions
3) Properties of
Membrane Component
5) What is the issue number of the
article? If any
1) The Soviet Space Program: Effort
Said to Surpass Peak U.S. Level
2) Evidence for proteins embedded in
membrane.
6) How many page numbers are in
the article?
13 pages
7) What is the date (year) of the
article?
12/09/2008
8) Find three (3) scientific terms in
the article.
1) Mosaic structure of the proteins and
lipids of membranes.
2) The fluid mosaic model has evolved
by a series of stages from earlier
version.
3) Protein-lipid interactions in
membranes
9) State the objective of the article
(goals or purpose).
To observe the fluid mosaic model of
the structure of cell membrane.
2. SUMMARY
The article that I studied about is an article no.5. This article is about the fluid mosaic
model of the structure of the cell membrane that was authored by S. J. Singer and Garth L.
Nicolson. As I studied this article, I realised that cell membranes are viewed as two-
dimensional (2D) solutions of oriented globular proteins and lipids. This article contains
many facts and information about the mosaic model and its function to ensure the mosaic
model development has knowledgeable for future generations.
This article have contains many topics that has good information about the mosaic
model and its structure. First of all, the first contain is about the cell membrane undergo
thermodynamics process by evolved by a series of stages from earlier versions.
Thermodynamics also considered that about membranes and membrane components initiated,
and are still central to their development. This process derived from two decades of intensive
studies of protein and nucleic acid structure to form complex membrane structure. t. These
principles and their application to membrane systems have been examined in detail elsewhere
and are only summarized here. Besides that, thermodynamics related free energy terms no
doubt provide the reasons why essentially all the ionic residues of protein molecules are
observed to be in contact with water usually on the outer surface of the molecule, according
to x-ray crystallographic studies.
Other than that, in the article contain some properties of membrane components that
concluded in the mosaic model and its structural form such as peripheral protein and carrier
protein. Peripheral protein require only mild treatments, such as an increase in the ionic
strength of the medium or the addition of a chelating agent, to dissociate them molecularly
intact from the membrane and dissociated state they are relatively soluble in neutral aqueous
buffers. Integral protein states that well-characterized membrane systems, including
erythrocyte and other plasma membranes, and mitochondrial membranes, the proteins have
been shown to be grossly heterogeneous with respect to molecular weights. The phospholipid
bilayer substantial evidence that the major portion of the phospholipids is in bilayer form in a
variety of intact membranes in mosaic model. Next, the fluid in mosaic model contains
amphipathic proteins (lipoproteins) and lipids in instantaneous thermodynamic equilibrium,
leads to many specific predictions about the mechanisms of membrane functions.
This mosaic model and its structure can be related in our life because the mosaic
model are the cover layer of the cell in epidermal cell and plant cell to help achieve better
stabilise shape of cell. As we all know that mosaic model consistent with the restrictions
imposed by thermodynamics to undergo process inside the cell. Integral proteins are a
heterogeneous set of globular molecules, each arranged in an amphipathic structure, that is,
with the ionic and highly polar groups protruding from the membrane into the aqueous phase,
and the nonpolar groups largely buried in the hydrophobic interior of the membrane. Next,
we know the bulk of the phospholipid is organized as a discontinuous, fluid bilayer, although
3. a small fraction of the lipid may interact specifically with the membrane proteins. The fluid
mosaic structure is therefore formally analogous to a two-dimensional oriented solution of
integral proteins (lipoproteins) in the viscous phospholipid bilayer solvent. This concludes the
mosaic model and its structure help the organisms to achieve stable environment in their
lives.
