2. What is Squamous Cell Carcinoma
(SCC)?
Dysplastic proliferation of abnormal
keratinocytes may arise de novo
or
in pre existing skin lesions such as actinic
keratoses or Bowen’s disease.
Have invasive tumor cells within the dermis.
6. Risk factors
1. Increasing age
2. Fair skin
3. High intensity of UV exposure
4. Radiation
5. Immunosuppression
6. Previous history of SCC
7. Congenital disorders such as Gorlin’s syndrome
8. Chronic wound or scar ( Marjolin’s ulcer)
9. HPV
10. Transplant patient who are medically
immunosuppressed
10. SCC of the cheek/jawline area. The lesion is firm
and keratotic.
11. SCC of the mouth with keratotic at the
centre.
12. • Squamous cell carcinoma in situ: Bowen's disease.
• A large, sharply demarcated, scaly, erythematous plaque.
• Appears as a persistent red-brown, scaly patch that may resemble
psoriasis or eczema.
13. • Squamous cell carcinoma in situ :Erythroplasia of
Queyrat.
• Well demarcated, red, and shiny plaque on genital
mucosa.
14. • Keratoacanthoma
• Symmetrical, dome-shaped nodule with an
overlying thinned, telangiectatic epidermis and a
central keratin plug.
15. • Regional lymph nodes should be palpated
for local metastasis
• May have involvement of other organs
• Biopsy
• CT scan maybe indicated
16. Management
Surgical Medical
Ideally lesions should be excised with a
4-6mm margin
Skin grafting maybe required
Tumour curretage and cautery
Radiotherapy
In patient who develop multiple SCCs
such as renal transplant patient,
secondary prophylaxis maybe considered
with oral retinoids
18. Actinic keratosis
• A red, scaly plaque on light-
exposed skin due to
dysplastic epidermal
keratinocytes. It may affect
the face (including lower
lip), bald pate,
forearms, and dorsum of
the hands
• presenting as a red yellow
or beige plaque, 0.5–1 cm
in diameter, with surface
scale or crust. It may
ulcerate or develop a
cutaneous horn.
Editor's Notes
Actinic keratosis
A rapid proliferation of keratinocytes giving
rise to a squamo-proliferative nodule which
resolves spontaneously. Lesions occur on sunexposed
sites, particularly on the head and
upper limbs.