1. 1
INFECTIONS√
MOA
57. aminglycoside ?
protein synthesis inhibitor
64. aminoglycosides ?
protein synthesis inhibitor
83. Fluroquinolone
Fluoroquinolones act by inhibiting two enzymes involved in bacterial DNA synthesis, both of which are DNA topoisomerases that human cells
lack and that are essential for bacterial DNA replication, thereby enabling these agents to be both
54. Cephalosporin act ?
Inhibitors of cell wall synthesis
50. florouracil ?
is Pyrimidine derivative
31. choloroquine ?
choloroquine bind to heme and prevent it's polymerization to hemozin
87. Which Antibiotics that cover pseudomonas?
Cefepime, ceftazidime, Piperacillin, ticarcillin-clavulanate, Ciprofloxacin, levofloxacin, Amikacin, gentamicin, tobramycin, monobactam,
carbapenem
70. drug of choice for pseudomonal aeruginosa is ?
Meropenem
31. antipseudomonal? most choice cephalosporin
36. cover pseudomonas? Tobramycin
9. Doctor prescribe high dose of tobramycin 400mg/day for resistant strain why high dose?
Because of dose dependant killing of aminoglycosides
99. Patient with ear Tinnitus ?
betahistine
43. A child has otitis media first time what is the best medication?
high dose of penicillin-azithromycin- Bactrim
44. antibiotic needed in community acquired pneumonia which need hospitalization
ceftriaxone +macrolid >> hospital non ICU
Ceftriaxone plus either a respiratory fuoroquinolone or azithromycin >> ICU
73. drug of choice for pneumonia is ?
Pencillins
40. DOC for endocarditis?
penicillin G
4.If patient resistant to ampicillin?
Take ciprofloxacin
21. Pt in home care and he has a catheter Jitter chatter Must take? Ciprofloxacin
55. which one is more effective agaienst in traveller diarrhea (caused by E.coli)?
Ciprofloxacin
50. drug make complex with dairy product ?
Ciprofloxacin
. Ciprofloxacin contraindicated in children because effect on bone cartilage
59. drug of choice for giardiasis and amoeba ?
Metronidazole
74. which of the following is the drug of choice for giardiasis ?
metronidazole(flagyl)
20. Lab test with high k. drug cause this?
trimethoprim/sulfamethoxazol
5.The recommendations and direction depend on which in substance?
(trimethobrimsulfamethoxazole)
23. H. Pylori treatment in patient have penicillin resistant?
clarithromycin ..ppi....metronidazole
19. Case has Allergy of Amoxicillin H. Pylori ?
clarithromycin +metronidazole + omeprazole
. H.pylori treatment : PPI+ amoxicillin + clarithromycin
2. 2
91. Drug of choice for clamydia ?
Azithromycin 1 gram po ×1 or doxycycline
22. Patient has pneumonia and started treatment with Azithromycin po & ceftriaxone iv after
3 day the patient is stable what is the next step?
Stop azithromycin and continue ceftriaxone for 3 days
25. Treatment for Candida albican? Clotrimazole
27. Treatment for malaria? Chloroquine
29. Which macrolide safe with cyclosporine in renal replacement patient? ------------
71. amphotericin-b is ? Parentral anti fungal
39. MRSA drug of choice
Vancomycin is the first line in treatment of MRSA infection
30. MRSA? Vancomycin
35. Vancomycin trough peak monitoring? after 3rd dose before 4th
38. Vancomycin cause? red man syndrome
88. Which Antibiotic cover MRSA first line?
Vancomycin
89. Which Medication cause red man syndrome ?
Vancomycin
90. How could we solve the red man syndrome with vancomycin?
reduce infusion rate
92. Vancomycin trough?
Vancomycin trough levels should ideally be drawn immediately before administration of the fourth dose (within 30 minutes of the dose is
acceptable)
96. When should vancomycin peak levels be drawn ?
Peak levels are collected 1 to 2 hours after the completion of the intravenous vancomycin dose
13. Patient take 75mg vancomycin every 12 hours and the level is 7mch/dl the range level is
(20-10) the patient need dose adjustment to reach 10mcg/dl what is the dose needed?
82mg – 105mg
85. Maximum infusion rate for vancomycin?
5mg/ml
1ml/min
10 mg/min
. Vancomycin is : antipseudomonas drug
. Antipseudomonal antibiotic= piperacillin, carbenacillin, ticarcillin
7.Treatment of RSV respiratory synthial virus ? Palivizumab
14. Drug has role in RSV ( respiratory syncytial virus ) in newborn ?
Palivizumab for prevention and treatment
28. Passive immunization of infants against lower respiratory tract infections? Palivizumab
11. Patient take adlimumab for rheumatoids and he knew it may cause malignancy what to do?
tell him about benefits of drug versus risks
95.What is the treatment of ringworm and jock itches which known as tinea?
Ring worm in skin : Ketoconazol , Clotrimazol , Miconazol , Terbinafen
Ring worn in scalp : Fluconazol , Itraconazol , Griseofulvin , Terbinafen
145. What is the treatment of Athletes foot ?
Terbinafine topical
37. Pinworm treatment?------------
62. drug of choice for tape worms ?
Neclosamide
67. drug of choice for tape worms ?
praziquantel or neclosamide
60. Which of following is the drug of choice for treatment of all forms of Schistosomiasis?
Praziquantel
134. Which Medication used anti-malarial in Saudi Arabia? Primaquine
63. A drug is contraindicated with patients have G6PD deficiency suffering from malaria ? Primaquine
. Chloroquin : antimalarial
3. 3
14. Most important Structures of viral?
Nucleic acid
69. acyclovir is ?
used for herpes simplex
63. ganciclovir(antiviral) used in treatment of ?
Cytomegalovirus
64. zanamivir is used for treatment and prophylaxis of ?
Influenza
32. Flu treatment?
Oseltamivir
Voltrex is :Acyclovir
. Acyclovir used for: herpes simplex
87. drug use for allergic eye? ---------
88. OTC in treatment of ear? ---------
93. Before start doxorubicin check? ------------
102. Lyme disease is caused by ?
Lyme disease is caused by the bacterium Borrelia burgdorferi and rarely, Borrelia mayonii. It is transmimed to humans through the bite of
infected blacklegged ticks.
SKIN
8. Patient take doxycycline tablets and adapalene gel for acne He suffer from nausea and GIT
upset what to do?
take doxycycline with plenty of water
54. Which one of the following cannot be dispensed without prescription ?
Doxycycline
Interactions
47. Probenecid alters which of the following to prevent penicillin excretion?
renal tubular reabsorption
48. Drug makes complex with antacid ?
Doxycycline
49. Drugs that make complex with antacids?
(tetracyclines and fluoroquinolones)
classification
61.Cephalosporin act ?
Inhibitors of cell wall synthesis
80. what is the b-lactam antibiotic, its mode of action is cell wall synthesis inhibitor
Cephalosporin
92- Which of the following has similar antibacterial mechanism of penicillin?
cephalexin
2)Which is the best treatment for staphylococcus aureus positive mastitis?
Cephalexin
13- Which of the following mechanisms, cephalexin exert antibacterial effects?
inhibition of bacterial cell wall synthesis
53.which of the following is NOT macrolide antibiotic?
Chloramphenicol
76. Penicillin's are similar in MOA AS ?
Cephalexine
77. Which of the following show penicillinase resistance
flucloxacillin (floxacillin)
81. the aminoglycoside?
Antibiotic
82. ceftriaxone ?
"3rd generationcephalosporin
83. ceftazidime is ?
third generation cephalosporin
7- Which of the following best describes ceftazidime?
A third generation cephalosporin which covers gram negative and gram positive organisms
4. 4
94. In Agar picture which of the following sensitive ?
93. How is the Coronavirus transmimed?
respiratory
97. A medical student touched a patient suffering from Clostridium infection. The student use antiseptic wipes before and after exit from
patient room ?
wash with water and soap
98. Beta-lactam antibiotic is considered ?
Time dependent
103. patient with staph . aureus resistant vancomycin and all other antibiotics except linazolid , linazolid not approved for this case what
we can use ?
Use linazolid even not approved
104. which antibiotics not recommended to use due to destruction by alveolar surfactant ?--------------
Monitoring
34. Dose of ceftriaxone in meningitis?
2g bid
18. Dose of TMP/SMX is Depending on? ---------
86. What is the anti-fungal drug that need hepatic dose adjustments?
Caspofungin and voriconazole
45. drug need dose adjustment in renal failure?
Impeniem / cilastatin
51. drug need to monitor its plasma level ?
Gentamycin
68. drug need serum creatinine to be monitored ?
gentamycin (aminoglycoside)
100.When can take gentamycin sample in patient with dialysis ?
Before dialysis
101. Gentamicin peak and trough ?
trough: 30 minutes before 3rd or 4th dose.
peak: one hour after dose.
41. Gentamicin kinetics drawn after? Right before the 4th dose
46. Pt with Low creatinine clearance - high serum creatinine kidney injury contraindicated ? Gentamycin
Q- Patient use gentamycin when should i monitor ? after 30 minute of 4
th
dose
10- A nurse has an inquiry about the appropriate time to Withdraw a trough gentamicin level for a patient.
What is the best answer for her inquiry?
30 minutes after gentamicin administration
5. 5
SE
12. Antibiotic that cause hearing problem? Aminoglycosides , Gentamycin and Vancomycin
13. Which adverse reaction is irreversible? ototoxicity of gentamycin
16. Which cause irreversible ototoxicity and defness? Aminoglycoside
75. red man syndrome caused by ?
Vancomycin
33. Which one is reversible SE of aminoglycoside
Nephrotoxicity
42. TMP/SMZ Side. Effect on electrolyte
Hyperkalemia may occur, especially with higher doses
56. which antibiotic more likely to cause diarrhea ?
Augmentin
57. antibiotic with diarrhea as a side effect ?
Amoxicillin combination with clavunic
65. metronidazole used in treatment of ?
clostridium difficile
66. clindamycin cause ?
clostridium difficile
24. Which drug make teeth discoloration? Doxycycline
OLD
. Bactrim is cotrimoxazole (trimethoprim +cotrimoxazole)
. Pnumocystic carini pneumonia (PCP) = parasite
. Cefprazone, Lomifloxacin are antibacterial
.. Erythroped (erythromycin) : ⬆ GIT motility
. Erythroped is :against G+ cocci, is microlide, used in pregnancy, ⬆ GIT motility
. Tiecoplanin is similar to Vancomycin
. Floxapen (fluxacillin) is resistant to penicillinase
. Nitrofurantoin: for urinary tract infection
. cyclosporin: immunosuppressant after organ transplantation
. Clomiphene: inhibit - ve feedback of estrogen
. Tetracyclines : broad spectrum antibacterial
. Tetracyclines with Ca and Mg is poorly absorbed from GIT
. Tetracyclines used with expiry cause : Fanconi syndrome
. Imepenem (carbepenem) : first thienamycin B lactam
.
Cephalosporins
. Ampicillin = cephalexin (1st generation cephalosporin)
. Keflex is: 1st generation cephalosporin
. Cefaclor is 2nd generation cephalosporin (bronchodilator)
. Zinnat contains : Cefuroxime
. Suprax is: cefixime
. Sporanox is :Itraconazole
. Terbinafine is: local and systemic
. Miconazole is: local and systemic
.. Amphotericin : parenteral
. Griseofulvin : oral
. Sodium stiboglyconate used for leshmania
. Zidovudin used for :HIV & AIDS
. Zalcitabin used for: HIV
Antifungal
. Triazole: antifungal
6. 6
CHILD
14. Most OTC for children?
Antipyretic / 2-Analgesic
17. Child 4 years old has non-productive cough?
Dextromethorphan
5. Neonate doctor prescribe to him erythromycin eye ointment for ?
Chlamydia
8. Neonate with chalamedia infection what is the best antibiotics?
Erythromycin
18. Child patient with ADHD, symptoms appear in house and in school?
Methylphenidate
1.In child with ADHD what is the appropriate choice?
Methylphenidate once daily
2. Methylphenidate indication?
Attention deficit hyperactivity disorder (ADHD)
12. Drug has role in RSV ( respiratory syncytial virus ) in newborn ?
Palivizumab for prevention and treatmen
13. Case children with fever 48hr, tugging ear diagnosis?
otitis media
21. for otitis media in children use ?
high dose of amoxicillin
16. Child has penicillin resistant which drug will be used?
Cephalosporin
22. for a 4 year old child, the maximum daily dose of paracetamol is ?
1 g
10. Neonates water soluble ? 80%
3. Neonates term?
Suggested Age Groupings:
Premature Newborns: < 38 weeks’ gestational age
Term Newborns: > 38 weeks’ gestational age
Neonate: 0 – 30 days of age
Infant: 1 month – 2 years
Young Child: 2 – 6 years
Child: 6 – 12 years
Adolescent: 12 – 18 years
7. Dose of dry cough syrup for child?
Dextromethorphan
Cough suppressant
Adult: As dextromethorphan hydrobromide: As conventional preparation: 10-20 mg 4
hourly, or 30 mg 6-8 hourly. As extended-release preparation: 60 mg 12 hourly. Max: 120
mg daily. As loz: Suck not more than 12 loz daily.
Child: >12 years Same as adult dose.
6. Drug contraindication in children less than 12 year ?
At age
1- 28 days – ceftriaxone –
< 2 yeas – promethazine – fatal respiratory depression
< 12 yeas – codeine and tramadol – lethal overdose
9. Drug contraindicated in neonates?
Trimethoprim/sulfamethoxazol =( Smx-tmp )
15. Which drug contraindicated in children?
Doxycycline
SE
11. Medication cause growth retardation?
Glucocorticoids , Betamethasone, Cortisone, Dexamethasone, Hydrocortisone, Methylprednisolone, Prednisolone, Prednisone,Triamcinolone
20. gray baby syndrome caused by ?
Chloramphenicol
19. Ceftriaxone what cause on neonate?
Ceftriaxone cause hyperalbunimia in neonate
