In complement-dependent cytotoxicity (CDC), C1q binds to antibodies, triggering the complement cascade, resulting in the formation of a membrane attack complex (MAC) (C5b to C9) on the surface of target cells, further leading to classical pathway complement activation. Among these factors attributable to CDC resistance, soluble regulatory complement factor H (CFH) was found to fail to activate complement-dependent cytotoxicity (CDC).https://www.creativebiolabs.net/cdc-enhanced-antibody_77.htm