Total Dog Overhaul Challenge: Week 1
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Week 1 of this 30 Day Challenge. Core causes of chronic inflammation and anti-inflammatory foods.
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Total Dog Overhaul Challenge: Week 1
- 1. 30 DAY TOTAL DOG OVERHAUL CHALLENGE
- 2. 30 DAY TOTAL DOG OVERHAUL CHALLENGE
- 3. Hi, I’m Dana … • Raw feeding and natural rearing for over 20 years • Champion and specialty winning Labradors • As seen on ABC, CBS, CBC • Founder & CEO Dogs Naturally Magazine • Founder & CEO Four Leaf Rover Dana Scott Founder & CEO Dogs Naturally & Four Leaf Rover
- 4. Meet Audrey
- 8. WHICH FOUR WILL GET CANCER?
- 10. Inflammaging
- 13. The Challenge Diet as a foundation for health Week 1 Week 2 Understand & avoid inflammation Week 3 Remove inflammation triggers Week 4 Build the immune system
- 16. Chronic Inflammation The Silent Killer You can’t directly see the signs of chronic inflammation. Signs of Chronic Inflammation Obesity Diabetes Allergies Autoimmune Disease Cognitive Decline Immune Decline Arthritis Cancer
- 17. Waste Buildup
- 18. DNA Damage & Mutations
- 19. Genetics
- 22. Free Radicals
- 28. Inside The Gut
- 29. Oldest Fossil
- 30. Mitochondria
- 31. Mitochondria
- 32. Symbiosis
- 34. Bacteria
- 35. Bacteria
- 37. Bacteria Phyla
- 38. Leaky Gut
- 39. Leaky Gut
- 41. Microbiome
- 42. Broccoli
- 44. Polyphenols
- 45. Fasting
- 46. Probiotics
- 47. Anti-Inflammatory Foods FEED MORE: Broccoli (Nfr2) Turmeric (Nfr2) Polyphenols (Nk-kB and gut) Fasting (oxidative stress) Probiotics (gut) Omega-3 Fats (gut) 47
- 48. Anti-Inflammatory Plan THINGS TO FIX: Excess Weight Inactivity Stress Chemical Exposure Antibiotics Glyphosate Diet 48
Editor's Notes
- Why doing this challenge? Audrey - why is she different? It’s not just feeding raw. It’s not just skipping the HW meds - it’s a big part of it but they’re just the means to an end. I used to feed pig necks and chicken and thought oh it’s raw, it’s good. But it’s not enough - good news for kibble feeders - these changes don’t have to be expensive. These changes transcend raw vs kibble or prey model vs BARF. And it’s great if you can make all of these changes, but don’t feel guilty if you can’t. If you follow even half the steps in this challenge you’ll be making huge strides.
- 2016
- 2016
- These aren’t unrelated - one common denominator. Get to that in a moment.
- Average lifespan for dogs between 20 and 90 pounds is about 11 years. Dogs over 90 pounds? Just 8 years. Ultimately beating these odds is what it’s all about. Having dog that lives 15 or more years with few health problems is the holy grail. And that’s what we’re going to to focus on for the next 30 days.
- Over next 30 days going to talk about the changes you need to make in your dog’s life. And these are all changes you can complete in 30 days. Every one of these changes do just 1 thing … and it’s the #1 thing you need to focus on if you want your dog to live a long, healthy life. If you can always keep this goal in mind, you’ll always make the right decision for your dog. You’ll choose the right foods. You’ll make the right healthcare decisions. And you’ll return your dog to a naturally healthy lifestyle. These changes don’t have to be expensive. These changes transcend raw vs kibble or prey model vs BARF. And it’s great if you can make all of these changes, but don’t feel guilty if you can’t. If you follow even half the steps in this challenge you’ll be making huge strides. So what is the goal? How do we increase the odds your dog will live for 15+ years?
- The increase in diabetes, cancer, obesity, joint disease … they’re not unrelated. In fact … they are all the very same disease. They are all chronic inflammation. And it’s so prevalent that scientists have a name for it … inflammaging. Chronic, low-grade inflammation is the common cause of chronic disease and premature aging.
- Researchers now say chronic inflammation is the cause of heart disease in humans. When the immune system is constantly on high alert, inflammatory cells circulate in the blood vessels. This causes the dangerous buildup of plaque. Plaque triggers an even larger immune response. As the plaque grows, the arteries being to harden. This increases the risk of stroke and heart attack.
- So we only have one goal over the next 30 days … and that goal is to limit the amount of inflammation in your dog. And you can do that with the right food choices and the right lifestyle choices. So here’s a look ahead and how we’re going to accomplish this
- Journal?
- WHAT IS CHRONIC If your dog sprained her paw or stepped on a thorn, inflammation would follow. And it would be necessary for healing. Acute inflammation is the swelling, redness and pain at the site of injury or infection. This type of inflammation is a natural part of the immune system. The blood vessels in that area expand and become more permeable. This helps immune cells migrate out and help repair the affected tissues. But chronic, low grade inflammation is a problem. Chronic inflammation is an exaggerated and prolonged immune response. If it continues over long periods of time, your dog’s immune function will start to decline. Chronic, low-grade inflammation is connected to degenerative diseases, autoimmune diseases and diabetes. And most importantly, chronic inflammation can transform normal cells to malignant or cancer cells.
- Chronic inflammation will eventually cause organ disease. This is why older dogs have more problems with their kidneys, livers, hearts and other organs. Chronic, low-grade inflammation is the enemy of old age.
- Inflammation is a silent killer … you can’t see it. And most vets don’t measure it. But there are signs of inflammaging you need to watch for: But by the time you see these signs, inflammaging will be running somewhat rampant in your dog. So you need to address inflammaging before your dog develops chronic diseases. What if your dog already has one or more of these diseases? Fortunately, there’s still much you can do. So let’s look at what triggers chronic inflammation … and how you can slow down inflammaging in your dog.
- Your dog’s cells are constantly working. Cells continually generate energy, transcribe DNA, transport molecules, make enzymes and divide. These functions all create waste products. Cells need to continually take out the trash or they become tiny junkyards. Some of the waste is swept under the rugs or can’t be cleaned out at all. Over time, this waste builds up and starts to interfere with cell function.
- Your dog’s DNA is bundled in chromosomes inside his cells. DNA carries your dog’s genetic information. It determines the size, shape and function of every cell … and this determines the size, shape and function of every dog. Over time, DNA can change and mutate … especially in slowly dividing cells. DNA mutations cause premature aging. And older animals have cells with more mutations.
- Mothers can pass genetic mutations to their puppies. These mutations can predetermine how quickly the puppies age. If you want your dog to live a long life, you need to pick the right mother!
- At the end of each chromosome is a stretch of DNA called a telomere. Think of telomeres as the hard ends of shoelaces. Telomeres protect the ends of your dog’s chromosomes and stops them from unravelling. As your dog ages, her telomeres shorten … the older the dog, the shorter her telomeres. Every time a cell divides, the telomere gets shorter and shorter. Once the telomeres are gone, the cell will do one of three things: Self destruct (apoptosis) Go rogue (become cancerous) Retire (become senescent) If the immune system is functioning well, it can pick up and destroy the cancerous cells. The body is constantly living with cancer and is well equipped to deal with it. Senescent cells do the most harm.
- One bad apple can ruin the whole cart … that’s exactly how senescent cells cause inflammaging. They hang around the body and release toxic chemicals. These chemicals start to stick to surrounding healthy cells, causing hem to become senescent or cancerous. The accumulation of senescent cells creates a large amount of inflammation. A 2019 study showed that removing senescent cells from the hearts of old mice restored heart health and reversed cardiac aging.
- Free radicals are molecules with an unpaired electron. Electrons like to be in pairs, so single electrons make free radicals unstable. These unstable molecules will steal electrons from their neighboring molecules. This causes chemical reactions called oxidation. Antioxidants are molecules that can donate an electron to free radicals without becoming unstable themselves. This prevents free radicals from building up and causing damage to cells and DNA. If there are more free radicals than antioxidants, inflammation will follow. This is called oxidative stress and it’s a major cause of aging.
- So now you know the physiological causes of chronic inflammation in your dog. Next, let’s look at how it happens. What lifestyle choices can turn inflammation on
- two signalling pathways - one turns it on one turns it off NF-kB Pathway The nuclear factor-kappa B (NF-kB) pathway is a major factor in chronic inflammation. It’s activated by nearly 200 different stimuli. Pro-inflammatory proteins enter the the cell and start this pathway. Once activated, the NF-kB pathway gets into your dog’s DNA and changes how it’s expressed. It controls the activation of over 400 different genes … and when the inflammatory genes are activated, inflammatory proteins are produced. When NF-kB pathway is activated it will cause tumor growth and development, metastasis and chronic inflammation.
- Nrf2 Pathway Nuclear factor erythroid 2-related factor 2 This pathway is a major factor in decreasing chronic inflammation. It regulates over 200 different genes and activates antioxidant genes. It also deactivates carcinogens (cancer promoting substances) and helps exit them from the body.
- GOOD NEWS - And we’ll focus on this. These pathways can be switched on or off … and many of the choices you make for your dog will determine which pathway is activated.
- Let’s take a quick look at how the Nf-kB pathway is activated. Excess Weight Dogs (and humans) that are overweight carry inflammatory markers in their fat. Inactivity An inactive dog is an inflamed dog. Regular activity activates the Nrf2 pathway. Stress Dogs can often lead stressful lives … including bored or lonely dogs. Chronic stress activates high levels of cortisol. Normally, cortisol turns off the Nf-kB pathway … but chronic stress causes tissues to become less sensitive to cortisol. Chemical Exposure The chemicals your dog is exposed to can activate the NF-kB pathway. This is especially true of heavy metals such as lead, mercury and aluminum. The top sources of heavy metals are vaccines and foods. Food Some foods are inflammatory while others are anti-inflammatory. We’ll look at anti-inflammatory foods in a bit, but let’s first talk another really important cause of inflammaging …
- The microbiome is made up of the colonies of microorganisms that live in your dog’s gut. Most of these microorganisms are bacteria. Bacteria have evolved alongside animals and they’re critical to health and disease.
- What we’re looking at here is the oldest known fossil. It’s 3.7 billion years old … which is 14 times older than the dinosaur. The earth itself is only 4.5 billion years old. This is a bacterium … the oldest inhabitant on earth. And it’s the common ancestor for every life form on earth today. Just like we carry sea water inside of us, we still carry bacteria. They’re a part of us. Here’s how pervasive and important bacteria are to life …
- Inside your dog’s cells are tiny power plants that drive all activity. They are like the tiny little battery packs that fuel the cells. Mitochondria are responsible for cellular respiration, which is the process of digesting organic molecules and converting them to energy in the form of glucose and water. Mitochondria are so important to cells that they have their own DNA. They can even replicate themselves if the cell needs more fuel.
- It’s like they’re completely different beings living inside your dog. And look at how similar they are to bacteria. Some scientists today believe mitochondria might just be bacteria.
- Whether mitochondria are bacteria or not, it’s important to remember that we mammals have a very close symbiotic relationship with bacteria. Plants do too. Symbiotic relationships are common in nature. In the case of your dog’s microbiome, your dog gives bacteria a nice neighborhood to live in. They hang out and eat his food and they stay warm and cosy. And many bacteria species deliver health benefits to your dog in return.
- Bacteria are so connected to your dog’s health that they can control his brain and immune system. They also manufacture B vitamins and vitamin K, amino acids enzymes for digestion and bolster the lining of your dog’s gut. And bacteria can produce inflammatory or anti-inflammatory substances. The bacteria living in your dog outnumber his own cells by 10 to 1. A healthy microbiome is one that has a large and diverse population of bacteria. If the bacteria populations aren’t large and diverse, toxic bacteria can colonize in the gut. This is called dysbiosis and it’s a major cause of inflammaging.
- Most of the bacteria living in your dog’s gut are commensal bacteria. Commensal in Latin roughly means to eat at the same table. And that’s important to remember … because what you feed your dog will feed different species of bacteria in his gut.
- The vast majority of bacteria in your dog’s gut live in his colon or large intestine. That’s because one thing commensals love to eat is fiber. Your dog isn’t able to digest fiber … so it passes intact through the digestive tract to the colon … and feeds commensal bacteria living there.
- That’s why fiber is called a prebiotic … it is eaten or technically fermented by the bacteria living in the colon … and the probiotic then makes lactic acid and short chain fatty acids from it. These SCFAs are transferred to the liver for use in the body … but butyrate or butyric acid can bolster the cells lining the gut and build mucus… which helps prevent or repair leaky gut. Butyrate can also help build immune T cells in the immune system … and this reduced inflammation in the body.
- Getting back to the gut bacteria, the main two bacteria phyla are Bacteroidetes and Firmicutes. Firmicutes bacteria are the most numerous in the gut, followed by Bacteroidetes. Research in dogs shows that kibble fed dogs have a ratio of about 4:1 while raw fed dogs have a ratio of about 3:1. A large Firmicutes population will increase inflammation and decrease the proteins that attach the cells of the gut lining together. So it’s important to know that diet can change the bacterial populations in your dog’s gut … and this changes his health.
- OK - so why am I telling you all about bacteria and the microbiome? It’s because dysbiosis is a major cause of chronic inflammation … especially if it progresses to a condition called leaky gut.
- The only thing that separates the contents of the small intestine from the body is a single layer of tiny epithelial cells and some mucus. This makes it easy for your dog to absorb nutrients … but it makes her gut susceptible to leaky gut. If your dog has dysbiosis, harmful bacteria can colonize. They produce toxic byproducts, which cause NF-kB activation in the epithelial cells. When the epithelial cells become inflamed, the gap between them will open up. This allows toxins, undigested proteins and immune factors to escape the intestines and get into your dog’s body. This is leaky gut. As your dog ages, her microbiome diversity decreases. But if you make some lifestyle changes for her now, it doesn’t have to. A 2017 study in China showed that healthy older humans can have microbiomes that are similar to healthy young humans.
- So protecting your dog’s microbiome plays a key role in slowing inflammaging. Your dog’s microbiome can be harmed by: Disease Drugs, chemicals and toxins Genetics Antibiotics Glyphosate The wrong foods Feeding your dog the wrong foods can activate the NF-kB pathway … and cause dysbiosis and leaky gut.
- As your dog ages, her microbiome diversity decreases. But if you make some lifestyle changes for her now, it doesn’t have to. A 2017 study in China showed that healthy older humans can have microbiomes that are similar to healthy young humans. OK - so that’s a lot of information! And we’re laying the foundation for the next 3 weeks. This is the WHY of what we’re going to change and why we need to change it. As we go through the next sessions, it will all start to make sense for you. But I don’t want to leave you feeling like there’s nothing you can do tonight, so let’s take a couple of minutes to look at some powerful anti-inflammatory foods you can add to your dog’s diet today.
- Of all the substances you can feed your dog, nothing activates the Nrf2 pathway more than any sulforaphane. Sulforaphane is also a powerful antioxidant and liver detoxifier. Sulforaphane is found in all cruciferous vegetables like bok choy and cabbage … but it’s found in highest concentrations in broccoli. Broccoli sprouts contain even more sulforaphane, as do the seeds. SCOTTISH TERRIERS that ate dark leafy green, yellow and orange vegetables 3 times a week or more had a 90% decrease in cancer risk … and there was a 70% reduction in dogs eating cruciferous vegetables only. If you feed your dog broccoli or other cruciferous vegetables, be sure to mulch it and not cook it. Heat will destroy the sulforaphane and myrosinase, the enzyme the converts in in the body.
- Curcumin, the active ingredient in turmeric, also activates the Nrf2 pathway and decreases the Nf-kB pathway.
- Polyphenols are compounds that are only found in plants, especially berries. Polyphenols down-regulate inflammation by inhibiting the Nf-kB pathway. They’re also powerful antioxidants and prebiotics that help maintain a healthy microbiome.
- Fasting your dog also helps control inflammaging. Fasting reduces oxidative stress, which shortens telomeres. Consider fasting your dog once or twice a week … or feeding him just once a day.
- Probiotics are beneficial bacteria that colonize in your dog’s gut. Probiotics help increase the diversity and balance in your dog’s microbiome. Look for a probiotic that contains at least 10 strains and 30 billion CFU (colony forming units) to be sure there are enough bacteria to colonize. Soil-based probiotics are less fragile so you can choose one or two strains and your dog will need less than a billion CFU. Make antibiotics from Bacillus subtilus. Don’t know if dairy increases inflammation or not. On study linked yoghurt to increased risk of type 2 diabetes and one linked cheese. Lactose quickly converted to glucose - insulin. If do dairy make sure it’s organic. Pesticides, antibiotics, growth hormone.
- Going to talk more about omega-6 an omega-3
- Next week - FOOD
- Journal - note changes. Document your fears and how you’re going to overcome them.
- Journal - note changes. Document your fears and how you’re going to overcome them.
- Nothing magical about the raw diet