This document contains multiple choice questions about antileprotic and antitubercular drugs. Some key points addressed include: - Isoniazid is the safest antitubercular drug to use in patients with hepatitis. - Ethambutol can cause retrobulbar neuritis. - Rifampicin causes orange colored urine and is the most bactericidal agent for treating leprosy. - Ethambutol is most likely to cause inability to distinguish colors if used long-term for multidrug resistant tuberculosis.

1. Antileprotic drugs

14. • Which of the following antitubercular drugs
is safe in hepatitis?
• (a) Isoniazid
• (b) Rifampicin
• (c) Pyrazinamide
• (d) Ethambutol

15. • A diabetic patient develops cellulitis due to
Staphylococcus aureus that was found to be
methicillin resistant on the antibiotic sensitivity
testing. All of the following antibiotics will be
appropriate EXCEPT:
• (a) Vancomycin
• (b) Imipenem
• (c) Teicoplanin
• (d) Linezolid

16. • Prolonged treatment with INH leads to
deficiency of?
• (a) Pyridoxine
• (b) Thiamine
• (c) Pantothenic acid
• (d) Niacin

17. • Commonest side effect of Dapsone is:
• (a) Hemolytic anemia
• (b) Thrombocytopenia
• (c) Cyanosis
• (d) Bone marrow depression

18. • Ethambutol causes
• (a) Retrobulbar neuritis
• (b) Deafness
• (c) Red urine
• (d) Peripheral neuritis

19. • In leprosy, the best bactericidal agent is:
• (a) Clofazimine
• (b) Dapsone
• (c) Rifampicin
• (d) Ethionamide

20. • A patient suffering from AIDS is on zidovudine,
lamivudine and indinavir therapy. He develops
pulmonary tuberculosis for which treatment is
started. Which of the following should be
avoided in him?
• (a) INH
• (b) Ethambutol
• (c) Pyrazinamide
• (d) Rifampicin

21. • The primary reason for the use of drug
combination in the treatment of tuberculosis is
to:
• (a) Ensure patient compliance with the drug
regimen
• (b) Enhance activity against metabolically inactive
• mycobacteria
• (c) Delay or prevent the emergence of resistance
• (d) Provide prophylaxis against other bacterial
infections

22. • ATT causing orange coloured urine is
• (a) Rifampicin (DNB 2002, 2005)
• (b) Isoniazid
• (c) Streptomycin
• (d) Pyrazinamide

23. • Which of the following antitubercular drug is
not hepatotoxic
• (a) Isoniazid
• (b) Rifampicin
• (c) Ethionamide
• (d) Streptomycin

24. • Corticosteroids are absolutely
contraindicated in the following type of
tuberculosis:
• (a) Miliary
• (b) Meningeal
• (c) Intestinal
• (d) Renal

25. • A patient of multidrug resistant tuberculosis is
on antitubercular drugs. After a few months he
develops an inability to distinguish between red
and green color. Most likely drug causing these
symptoms is:
• (a) Rifampicin
• (b) Ethambutol
• (c) Cycloserine
• (d) Ethionamide

26. • In Lepra reaction, the drug useful is:
• (a) Pencillins
• (b) Clofazimine
• (c) Dapsone
• (d) Rifampicin

27. MCQ