Hydrogen oxygen ventilator (ams-h-03) H₂ 66.6% / O₂ 33.3% Proven Effective Against COVID-19 Hydrogen-Oxygen Mixed Gas Reduces Airway Resistance Breathing Hydrogen-Oxygen Mixed gas Decreases Inspiratory Effort in Patients with Tracheal Stenosis Hydrogen-Oxygen Mixed Gas Reduces Cytokine Storm Hydrogen-Oxygen Mixed Gas Against Sepsis Hydrogen-Oxygen Mixed Gas on European Respiratory Journal

1. A S C L E P I U S M E D I T E C C O . , L T D
Fight Against COVID-19 Effectively
Medical-Grade
Hydrogen Oxygen
Ventilator

2. HYDROGEN OXYGEN
VENTILATOR (AMS-H-03)
H₂ 66.6% / O₂ 33.3%
Asclepius Meditec Co., Ltd

3. BACKED BY
DOCTORS &
MEDICAL EXPERTS
We have worked with academician Dr. Zhong
Nanshan, head of the high-level expert group
appointed by China's National Health
Commission and several prestigious medical
centers and hospitals including Leishenshan
Hospital, Wuhan Hanyang Hospital, Guangzhou
Eighth People's Hospital...etc which has
achieved positive clinical results with our
latest trials involving over 3,000 COVID-19
patients with mild to severe symptoms.
Asclepius Meditec Co., Ltd

4. PROVEN EFFECTIVE
AGAINST COVID-19
Asclepius Meditec Co., Ltd

5. Hydrogen-Oxygen Mixed Gas
Reduces Airway Resistance
Asclepius Meditec Co., Ltd

6. Asclepius Meditec Co., LtdZhou et al. Respiration. 2018;97(1):42-51

7. Zhou et al. Respiration. 2018;97(1):42-51
Breathing Hydrogen-
Oxygen Mixed gas
Decreases Inspiratory
Effort in Patients with
Tracheal Stenosis
Asclepius Meditec Co., Ltd
*Method for connecting H2-O2 to the IOS
system. a Loud speaker, (b) screen flap, (c)
Y-adapter, (d) pneumochomatograph, (e)
mouthpiece, (f) a T-branch pipe, which
connects H2-O2 to the IOS system.

8. Asclepius Meditec Co., LtdZhou et al. Respiration. 2018;97(1):42-51
Δ%, percentage change compared with breathing Air or O2; sEMGdi-L%max and sEMGdi-R%max, percentage
of maximal left/right surface-EMGdi, respectively, from 16 patients; EMGdi%max, percentage of maximal
EMGdi from 19 patients; Pdi, transdiaphragmatic pressure. Values are the mean ± SD.

9. Asclepius Meditec Co., LtdZhou et al. Respiration. 2018;97(1):42-51
(a) Trends in the variability of left and right sEMGdi of 16 patients over time,
(b) trends in the variability of EMGdi of 19 patients over time.

10. Hydrogen-Oxygen Mixed Gas
Reduces Cytokine Storm
Asclepius Meditec Co., Ltd

11. HYDROGEN-OXYGEN
MIXED GAS
AIRWAY RESISTANCE ↓
CYTOKINE STORM ↓
Since molecular H₂ is safe and can reduce
free radicals and inflammatory cytokines,
the inhalation treatment is expected to
reduce cytokine storm.
Asclepius Meditec Co., Ltd

12. Hydrogen-Oxygen Mixed Gas
Against Sepsis
Asclepius Meditec Co., Ltd

13. Asclepius Meditec Co., LtdInt J Biol Sci 2019; 15(6):1261-1275

14. MOLECULAR
HYDROGEN EXERTS
BIOLOGICAL EFFECTS
Molecular hydrogen can be ingested in a
variety of ways and exerts biological effects,
including anti-oxidation, anti-inflammation,
anti-apoptosis, anti-shock, and autophagy
regulation through scavenging free radicals
directly and regulating signal transduction and
gene expression indirectly.
Asclepius Meditec Co., Ltd

15. EFFECTS OF MOLECULAR
HYDROGEN ON
OXIDATIVE STRESS
Molecular hydrogen antagonizes oxidative
stress through multiple pathways, including
neutralizing ·OH and ·ONOO-, reducing ·NO
production, upregulating antioxidant gene
expression (SOD, HO-1, CAT, and MOD),
suppressing NADPH oxidase activity, and
reducing 8-iso-PGF2α and MDA. ·OH: hydroxyl
radicals; ·ONOO-: peroxynitrite anions; SOD:
superoxide dismutase; CAT: catalase, MOD:
myeloperoxidase; MDA: malondialdehyde;
iNOS: inducible nitric oxide synthase; eNOS:
endothelial nitric oxide synthase; NADPH
oxidase: nicotinamide adenine dinucleotide
phosphate oxidase.
Asclepius Meditec Co., Ltd
Int J Biol Sci 2019; 15(6):1261-1275

16. MECHANISMS OF
MOLECULAR HYDROGEN
AGAINST OXIDATIVE
STRESS IN SEPSIS
(a) Molecular hydrogen eliminates LPS-induced ROS by
direct neutralization, promoting HO-1 expression
mediated by Nrf2, and inhibiting LPS-induced ET-1
activation. (b) Molecular hydrogen reduces MDA by
inhibiting activation of MAPK and NF-κB signaling induced
by LPS. (c) Molecular hydrogen increases antioxidant
enzyme activities, such as CAT and SOD. (d) Molecular
hydrogen suppresses NADPH oxidase activity. EMT:
epithelial-mesenchymal transition; PF: pulmonary fibrosis;
BPD: bronchopulmonary dysplasia; Nrf2: nuclear factor
erythroid 2-related factor 2; TLR4: toll-like receptor 4;
MyD88: myeloid differentiation primary response 88; MDA:
malondialdehyde; ROS: reactive oxygen species; HO-1:
heme oxygenase 1; CAT: catalase; SOD: superoxide
dismutase Asclepius Meditec Co., Ltd
Int J Biol Sci 2019; 15(6):1261-1275

17. BACK BY THE
GOVERNMENT
The Chinese medical team has recommended use of 66.6% H₂ / 33.3%
O₂ for inhalation for treatment of COVID-19 patients in the 7th edition
of new coronavirus pneumonia guideline released
by the National Health Commission of the PRC & National
Administration of Traditional Chinese Medicine and Program for the
Diagnosis and Treatment of Severe and Critical Cases of Novel
Coronavirus Pneumonia (Trial Version 3).
Since molecular H₂ is safe and can reduce free radicals and
inflammatory cytokines, the inhalation treatment is expected to
significantly improve the condition of cytokine storm.
Asclepius Meditec Co., Ltd
Source: NCBI Website (https://www.ncbi.nlm.nih.gov/pubmed/31223285)
ERS, European Respiratory Society (https://www.ers-education.org/home/browse-all-content.aspx?idParent=240043)

18. PROGRAM FOR THE
DIAGNOSIS AND TREATMENT
OF SEVERE AND CRITICAL
CASES OF NOVEL
CORONAVIRUS PNEUMONIA
Asclepius Meditec Co., Ltd
TRIAL VERSION 3

19. 《DIAGNOSIS AND
TREATMENT PROTOCOL FOR
NOVEL CORONAVIRUS
PNEUMONIA (TRIAL VERSION
7)》(RELEASED BY NATIONAL
HEALTH COMMISSION &
STATE ADMINISTRATION OF
TRADITIONAL CHINESE
MEDICINE ON MARCH 3,
2020) GENERAL
TREATMENT(CHAPTER 10,
SECTION 2.3)
Asclepius Meditec Co., Ltd

20. Hydrogen-Oxygen Mixed Gas
on European Respiratory
Journal
Asclepius Meditec Co., Ltd

21. Asclepius Meditec Co., Ltd

22. “In light of the significantly
decreased airway resistance and
safety, inhalation of hydrogen and
oxygen mixed gas which is
generated through water electrolysis
has been applied in clinical practice.
Hydrogen/oxygen mixed gas
inhalation resulted in a major
amelioration of dyspnea in most
patients with Covid-19 in a pilot
investigation, and has therefore
been endorsed by the latest
Recommendation for the Diagnosis
and Management of Covid-19
document [31]. “
Asclepius Meditec Co., Ltd

23. MUCH MORE AFFORDABLE SOLUTIONS
TO SOLVE VENTILATOR SHORTAGE
Asclepius Meditec Co., Ltd

24. Asclepius Meditec Co., LtdNMPA (National Medical Products Administration) Certificate

25. TALK TO US!
Benny Lin, +86-13774356437, benny.lin09288@ascleway.com
Peggy.Lai, +86-18861627975, peggy.lai09063@ascleway.com
Wenyn Wang, +886-958676519, wenyn.wang09350@ascleway.com
GLOBAL BUSINESS TEAM
No. 758, Jiaxin Road, Malu Town, Jiading District, Shanghai, China
OFFICE ADDRESS
Asclepius Meditec Co., Ltd