1. Ben Danielson
Ben T. Danielson, PhD
203 Swain Way
Palo Alto, CA 94304
708-280-2340
BenTDanielson@gmail.com
OBJECTIVE
PhD level cell biologist and immunologist looking for an opportunity to contribute to
pharmaceutical research. Experienced in cell and mouse modeling, drug characterization, and
pre-clinical research. Organized, enthusiastic, and hardworking.
EDUCATION
East Carolina University
Ph.D. (Anatomy and Cell Biology), 2009-15
Advisor: Warren Knudson PhD
Thesis Title: The Extracellular Processing of Aggrecan Aggregate and its Effect on CD44
Mediated Internalization of Hyaluronan.
Iowa State University
BS (Biochemistry), 2005-09
RESEARCH EXPERIENCE
Stanford University School of Medicine, Stanford, CA
Division of Infectious Diseases and Geographic Medicine
Postdoctoral Research Fellow, 2015-present
Advisor: Paul Bollyky MD PhD
Studying the role of the extracellular matrix and an experimental drug in modulating immune
cell function.
East Carolina University, Greenville, NC
Department of Anatomy and Cell Biology
Graduate student, 2009-15
Investigated the catabolism of extracellular matrix components of articular cartilage in early
onset osteoarthritis.
Iowa State University, Ames, IA
Biochemistry
Undergraduate Research Assistant 2006-09
TECHNICAL SUMMARY
Flow Cytometry, cell culture, PBMC isolation (dendritic cells and T-cells), in vitro and in vivo
models, mammalian cell transfections, proliferation and apoptosis assays, Western blot, ELISA,
immunoprecipitation, agarose gels, isolation and purification of extracellular components
(hyaluronan and proteoglycans), protein purification, generation of fluorophore-conjugated matrix
macromolecules, solution based enzyme assays, chromatography, immunohistochemistry, and
fluorescent microscopy.
TEACHING RESPONSIBILITIES
Mentor, trained rotation students, Stanford University, 2016
Teaching Assistant, Gross Anatomy, East Carolina University, 2010
2. Ben Danielson
Tutor, Medical Gross Anatomy, East Carolina University, 2010-13
Tutor, Histology, East Carolina University, 2010-13
GRANT
T32 Ruth L. Kirschstein National Research Service Award 2016
NIH
Tissue Integrity Signals and Regulatory T cell Homeostasis
The goals of this project are to define how the extracellular matrix, particularly high molecular
weight hyaluronan, promotes regulatory T-cell viability in healthy peripheral tissues.
HONORS AND AWARDS
2013 Carol Volkman Award: for best poster presentation of graduate research, Research and
Creative Achievement Week, East Carolina University, Greenville, NC
2011 North Carolina Graduate Education Day: 1 of 2 students chosen to represent East Carolina
University at the North Carolina State capitol, Raleigh, NC
2005 Rotary Scholarship, for academic merit.
PEER-REVIEWED PUBLICATIONS
Danielson, B. T., Knudson, C. B., and Knudson, W. (2015) Extracellular processing of the
cartilage proteoglycan aggregate and its effect on CD44-mediated internalization of hyaluronan.
Journal of Biological Chemistry
Daisuke Hida, BenDanielson, Emily B. Askew, Cheryl B. Knudson and Warren Knudson.
(2015). CD44 knockdown in bovine chondrocytes results in release of bound HYAL2. Journal
of Matrix Biology
MANUSCIPTS IN PREPARATION
Ben Danielson, Che-Hong Chen, Gernot Kaber, Daria Mochly-Rosen, Kevin Grimes, Robert
Stern, and Paul L. Bollyky. (2016). Human Chitotriosidase Does Not Catabolize Hyaluronan
V.G. Sunkari, N. Nagy, B Danielson, M. Bogdani, A. Preisinger, J.A. Gebe, S. Balaji, G.
Navarro, Z. Zhao, H.F. Kuipers, H. Ishak, J. Edwards, S. Hasbun, S.G. Keswani, T.N. Wight,
J.P. Annes, and P.L. Bollyky. Inhibition of Hyaluronan Synthesis Increases Insulin Sensitivity
and Insulin Production. (submitted).
G Kaber, SG Keswani, B. Danielson, and PL Bollyky, and V de Jesus-Perez. Treatment with
Matrix-Conjugated IL-10 reduces BLEOMYCIN induced lung fibrosis via stat3 dependent
suppression of TGF signaling.
N Nagy, P. Marshall, H. Kuipers, B. Danielson, PL Bollyky. Hyaluronan in autoimmunity. (in
revision).
CONTINUING MEDICAL EDUCATION
2016 The Federation of Clinical Immunology Societies, advanced course in basic and clinical
immunology, Scottsdale, AZ.
3. Ben Danielson
CONFERENCE PRESENTATIONS
East Carolina University Research and Creative Achievement Week,2011
Presented research on bioengineering cartilage to study anabolic and catabolic metabolism of
genetically modified cells.
1st
Annual North Carolina Graduate Education Day, North Carolina State capital, 2011
Discussed my research on the use of bioengineered cartilage to study tissue degeneration
associated with osteoarthritis and possible repair mechanisms.
East Carolina University Research and Creative Achievement Week,2012
Presented data on the extracellular processing of aggregate and its effect on CD44 mediated
internalization of hyaluronan.
North Carolina Cartilage-Arthritis Research Alliance, 2012
Presented my work on extracellular processing of aggregate and its effect on CD44 mediated
internalization of hyaluronan.
East Carolina University Research and Creative Achievement Week,2013
Presented an update on my work on extracellular processing of aggregate and its effect on
CD44 mediated internalization of hyaluronan.
International Society for Hyaluronan Sciences, 2013
Presented my work on extracellular processing of aggregate and its effect on CD44 mediated
internalization of hyaluronan.
North Carolina Cartilage-Arthritis Research Alliance, 2013
Presented on the extracellular processing of aggregate and its effect on CD44 mediated
internalization of hyaluronan.
Stanford Immunology Annual Scientific Conference, 2016
Presented work on tissue integrity signals and regulatory T cell homeostasis.
COMMUNITY SERVICE
Ronald McDonald House
Volunteer, 2009-13
Planned social events for children and their families
Greenville Humane Society
Volunteer, 2011
Fostered animals showing signs of dementia
Eastern North Carolina School for the Deaf
Fundraiser, 2013-14
Solicited donations from local retailers for fundraising events
East Carolina University Researchand Creative Achievement Week
Moderator, 2014
Moderated oral presentations for undergraduate research projects
East Carolina University Researchand Creative Achievement Week
Judge, 2014
Judged poster presentations for undergraduate research project