Nepal is a developing country and for its development, roadways are the most efficient transportation mode for trade, movement, and economy. Making roads in Nepal is a challenging task due to its challenging terrain. Excavations, drilling, and blasting during road construction, deforestation, heavy monsoon rain, and poor drainage system affect the natural slope and ground positions inviting slope stability issues. Earthquakes play a huge role in it too. When landslides and mass movements occur, the road gets blocked. This affects the mobility of travelers, disrupts trade and business in the area, disturbs the natural environment and a large amount of money needs to be spent on applying corrective measures for rehabilitation. Such slope failures prove deadly to mankind and bring a huge economic burden to the region and nation itself if the time value of cost is also considered. Realizing the sensitivity of the issue, bio-engineering has been adopted to mitigate the problems associated with slope instability in different areas of Nepal. Hence this study discusses the need for bio-engineering, investigates the bio-engineering measures applied in different parts of Nepal to date, and suggests possible bioengineering measures that can be implemented in the case of the Kathmandu-Nijgadh Fast Track project.