This document provides information on pulmonary embolism (PE). It defines PE as thrombosis originating in the venous system and embolizing to the pulmonary arterial circulation. PE contributes to 5-10% of hospital deaths. Risk factors include prolonged immobility, recent surgery or trauma, and inherited or acquired thrombophilias. Symptoms include dyspnea, chest pain, coughing up blood. Diagnostic tests include D-dimer, CT pulmonary angiogram, ventilation-perfusion scan, echocardiogram. Treatment involves anticoagulation with heparin or novel oral anticoagulants to prevent early death and recurrence, as well as thrombolysis for massive PE to restore pulmonary blood flow.
3. INTRODUCTION
⢠PE contributes to 5 to 10% of deaths in hospitalized cases (Alikhan et al.2004)
⢠Also accounts for 20-30% of deaths associated with pregnancy and delivery
⢠As per systemic review literature on the global disease burden (Western
Europe,North America, Australia and Sothern latin America)
⢠Annual incidence of pulmonary embolism ranges between 0.75 to 2.69 per 1000
populations
⢠Incidence increased to between 2 to 7 per 1000 population of age above 70 years.
4. ⢠About 70% of cases of Acute PE are caused by pelvic or leg thromboses.
⢠DVT and PE are different presentations of the same underlying pathophysiological
event i.e venous thromboembolism (VTE).
⢠One of the big three cardiovascular killer along with MI and stroke.
5. Predisposing factors
⢠Virchows triad for thrombogenesis
⢠Stasis: bed rest, inactivity, CHF, CVA within 3 mnth, air travel>6 h
⢠Injury to endothelium: trauma, surgery, prior DVT , inflammation
⢠Thrombophilia; protein c or s deficiency, prothrombin gene mutatuion,,
increased factor VIII, hyperhomocysteinemia, HIT, OCP, HRT, Tamoxifen,
raloxifene
⢠Malignancy (12% of idiopathic DVT/PE)
⢠Inflammation
⢠White infarct and red infarct a myth in present day understanding
6. ⢠Obesity
⢠Hypertension
⢠Smoking
⢠Hypercholesterolemia
⢠White clot vs red clot????
- Risk of arterial cardiovascular events doubles in VTE patients*
- *Becattini C et al, Incidence of arterial cardiovascular events after venous thromboembolism: a systemic review and meta analysis
10. Symptoms
⢠Dyspnea(sudden onset) most common
⢠Chest pain(pleuritic or atypical)
⢠Anxiety
⢠Cough and hemoptysis
⢠Dizziness or syncope (due to right heart failure)
11. Signs
⢠Tachypnea/tachycardia
⢠Hypoxia/cyanosis
⢠Low grade fever
⢠Cardiac :gallop rhythm,Jugular venous distension, loud P2, RV heave, widely
split S2., TR.
⢠Haemoptysis
⢠Leg oedema, erythema, tenderness(signs of DVT)
⢠Systemic hypotension and cardiogenic shock.
12. Long term complications
⢠Recurrent VTE
⢠Post PE syndrome
⢠Chronic thromboembolic pulmonary hypertension
⢠Post thrombotic syndrome (venous insufficiency)
13. Assessment of clinical probability
⢠Clinical judgement lacks standardization , therefore clinical prediction rules have
been developed
⢠Commonly used is the one offered by Wells et al.
⢠The revised Geneva rule is also simple and standardized
16. Classification of pulmonary embolism
category presentation
Massive pulmonary embolism(5%-10%) Systolic blood pressure<90 mm hg or poor tissue
perfusion or multisystem organ failure plus extensive
thrombus, such as âsaddleâ PE or right or left main
pulmonary artery thrombus
Submassive pulmonary embolism(20%-25%) Haemodynamically stable but moderate or severe
right ventricular dysfunction or enlargement, coupled
with biomarker elevation indicative of right ventricular
microinfarction and/or right ventricular pressure
overload
Small to moderate pulmonary embolism(70%) Normal haemodynamics and normal right ventricular
size and function
17.
18.
19.
20.
21. Diagnostic tests
labaratory
⢠Arterial blood gas: may reveal hypoxemia, hypocapnia and respiratory alkalosis
⢠Brain natriuretic peptide: BNP levels are greater in patient with PE compared to
other patients: elevation of BNP level correlates with risk of subsequent
complications and prolonged hospitalization.
⢠Troponin: serum troponin I and T are elevated in 30 to 50 % who have moderate
to large pulmonary embolism.
22. D-DIMER TESTING
⢠Simultaneous activation of coagulation and fibrinolysis in presence of acute
thrombosis causes elevated D-dimer levels
⢠Sensitivity of about 96% (Brown et al 2002). But low specificity.
⢠Negative predictive value of D-dimer testing is high and a normal D-dimer level
renders acute PE or DVT unlikely
⢠Fibrin is also produced in various condtions such as cancer, inflammation,
bleeding, trauma , surgery and necrosis, accordingly positive predictive value of
elevated D-dimer level is low and D-dimer testing is not useful for confirmation of
PE
⢠After age of 80 significance decreases
23. ⢠New D-dimer cut-off value:
⢠â< 50 years-old 500 ng/mL
⢠â> 50 years-old Patient age X 10 (e.g. 78-year-old patient, cut-off 780
ng/mL)
⢠Age-adjusted cut-off would increase the diagnostic yield of D-dimer by 10%
(from 25 to 35% of all patients tested)
24. Diagnostic Tests
ECG
⢠Sinus Tachycardia
⢠Atrial fibrillation
⢠P pulmonale
⢠RV strain patterns suggest severe PE
⢠Inverted T waves V1-V4
⢠Incomplete RBBB
⢠S1Q3T3 (first described by McGinn and White in JAMA in 1935) has sensitivity
of 54% and specificity of 62% (Ferrari et al 1997)
28. Diagnostic Tests
CXR
Chest radiograph findings in patient with pulmonary embolism
Result
Cardiomegaly
Normal study
Atelectasis
Elevated Hemidiaphragm
Pulmonary Artery Enlargement
Pleural Effusion
Parenchymal Pulmonary Infiltrate
29. Chest X-ray Eponyms of PE
29
Westermark's sign
⢠Focal , demarcated oligaemia
⢠Hamptonâs Hump
⢠A triangular or rounded pleural-based infiltrate with the apex toward the hilum,
usually located adjacent to the hilum.
⢠Pallaâs sign
⢠prominent right descending pulmonary artery
30.
31. Figure 1. Chest radiograph demonstrating focal oligemia in the right lung (area between white
arrowheads) and a prominent right descending pulmonary artery (black arrow).
Shiva Sreenivasan et al. Circulation. 2007;115:e211
Copyright Š American Heart Association, Inc. All rights reserved.
32. ⢠MELTING SIGN (rapid clearing in contrast to pneumonic consolidation)
⢠FLEISHNERâS SIGN (prominent central artery secondary to PHTN or
large PE)
33.
34. ECHOCARDIOGRAPHY
⢠Acute PE may lead to RV pressure overload and dysfunction, which can be detected by
echocardiography
⢠Disturbed RV ejection pattern (so-called â60â60 signâ) or on depressed contractility of the RV
free wall compared with the RV apex (âMcConnell signâ)
⢠Echocardiographic examination is not recommended as part of the diagnostic work-up in
haemodynamically stable, normotensive patients with suspected (not high-risk) PE
⢠This is in contrast to suspected high-risk PE, in which the absence of echocardiographic signs
of RV overload or dysfunction practically excludes PE as the cause of haemodynamic
instability
⢠Mobile right heart thrombi are detected by transthoracic or transoesophageal
echocardiography (or by CT angiography)
38. DIAGNOSTIC TESTS
CT Angiography
⢠Studies have shown sensitivity of close to 95% with an experienced observer
⢠One of the most commonly cited benefits of CTA is its ability to detect alternative
pulmonary abnormalities that may explain the patient's symptoms and sign
⢠It allows adequate visualization of the pulmonary arteries down to at least the
segmental level.
⢠Contrast enhanced MDCT-PA is currently the preferred method of diagnosis.
39. ⢠RV to LV dimensional ratio of 0.9 or greater
⢠IVS septal bowing towards LV
⢠Reflux of contrast medium into inferior venacavae
40.
41.
42.
43. Diagnostic tests
PULMONARY ANGIOGRAPHY
⢠Definite diagnostic test or gold standard in diagnosis of PE (less preferred)
⢠A filling defect or abrupt cutoff of a small vessel is indicative of embolus
⢠A negative pulmonary angiogram excludes clinically relevant PE
44.
45. V/Q SCAN
⢠Normal V/Q sensitivity 99% (r/o PE)
⢠High prob. V/Q specificity 96% (r/I PE)
⢠Lung scan results are frequently classified according to the criteria established in
the PIOPED study: normal or near-normal, low, intermediate (non-diagnostic), and
high probability of PE
46.
47. DIAGNOSTIC TESTS
MAGNETIC RESONANCE ANGIOGRAPHY
⢠The use of MRA for diagnosis of PE is limited by respiratory and cardiac motion
artefact
48. Diagnostic tests
LOWER LIMB ULTRASONOGRAPHY
⢠Proximal DVT in a patient with clinical suspicion of PE confirms PE
⢠Distal DVT further testing should be considered to confirm PE
⢠Almost 50% patients with symptomatic DVT have asymptomatic PE.
49.
50.
51. Treatment
⢠Respiratory support: supplemental oxygen if hypoxemia exists
⢠Hemodynamic support: patient with PE and hypotension, hemodynamic support
should be instituted
⢠Intravenous fluid administration
⢠Intravenous vasopressors: norepinephrine, dopamine or epinephrine may be
effective
⢠Dobutamine increases myocardial contractility and causes vasodilatation and
is ideal for cardiogenic shock
52. Treatment
Thrombolytic treatment
⢠Thrombolysis restores pulmonary perfusion more rapidly than anticoagulation
with UFH alone leading to a prompt reduction in pulmonary artery pressure and
resistance, with a concomitant improvement in RV function
⢠The greatest benefit is observed when treatment is initiated within 48 hours after
the onset of symptoms, but thrombolysis can still be effective in patients who
have had symptoms for up to 14 days
⢠Fibrinolysis results in 47% reduction in all cause mortality, 60% decrease in
recurrent PE at cost of 2.7 X risk of major bleeding and 4.6 X risk if ICH*
-*Chatterjee S. Chakraborty et al Thrombolysis for PE and risk of all cause mortality, major bleeding and ICH: a meta analysis
53. Treatment
Indication of thrombolysis
⢠Systemic thrombolysis should be considered only after acute PE has been confirmed
⢠Persistent hypotension ( systolic blood pressure of<90 mm hg or decrease in systolic BP by
>/40mm Hg from baseline
⢠Severe hypoxemia
⢠Large perfusion defect on ventilation perfusion scans
⢠Extensive embolic burden on CT
⢠Right ventricular dysfunction
⢠Free floating right atrial or ventricular thrombus
⢠Patent foramen ovale
54.
55. Advances in Catheter Based Therapy
⢠SEATTLE II trial with 24 mg t-PA
⢠Major bleeding in 10% with no ICH (vs 1% to 3% patients developing
ICH in patients receiving systemic thrombolysis.)
⢠Promising modality
⢠INDIGO thrombectomy system- microaspiration without using
fibrinolysis (US FDA approved 2019)
56. Treatment
Initiation of anticoagulation therapy
⢠Anticoagulation is recommended, with the objective of preventing both early death and
recurrent symptomatic or fatal VTE
⢠Consists of administering parenteral anticoagulation [unfractionated heparin (UFH), low
molecular weight heparin (LMWH), or fondaparinux] over the first 5â10 days
⢠Parenteral heparin should overlap with the initiation of a vitamin K antagonist (VKA);
alternatively, it can be followed by administration of one of the new oral anticoagulants:
dabigatran or edoxaban. rivaroxaban or apixaban
⢠Oral treatment with one of these agents should be started directly or after a 1â2 day
administration of UFH, LMWH or fondaparinux
⢠In this latter case, acute-phase treatment consists of an increased dose of the oral
anticoagulant over the first 3 weeks (for rivaroxaban), or over the first 7 days (for apixaban)
57. Treatment
Parenteral anticoagulation
⢠LMWH or fondaparinux are preferred over UFH for initial anticoagulation in PE, as they carry a
lower risk of major bleeding and heparin-induced thrombocytopenia (HIT)
⢠UFH is recommended for patients in whom primary reperfusion is considered, as well as for
those with serious renal impairment (creatinine clearance <30 mL/min), or severe obesity
⢠These recommendations are based on the short half-life of UFH, the ease of monitoring its
anticoagulant effects, and its rapid reversal by protamine. The dosing of UFH is adjusted,
based on the activated partial thromboplastin time (aPTT)
60. Treatment
Vitamin K antagonists
⢠Oral anticoagulants should be initiated as soon as possible, and preferably on the same
day as the parenteral anticoagulant
⢠VKAs have been the âgold standard' in oral anticoagulation for more than 50 years and
warfarin remain the predominant anticoagulants prescribed for PE
⢠Anticoagulation with UFH, LMWH, or fondaparinux should be continued for at least 5 days
and until the international normalized ratio (INR) has been 2.0â3.0 for two consecutive
days
⢠Warfarin can be started at a dose of 10 mg in younger (e.g. <60 years of age), otherwise
healthy outpatients, and at a dose of 5 mg in older patients and in those who are
hospitalized
⢠The daily dose is adjusted according to the INR over the next 5â7 days
63. Treatment
Surgical embolectomy
⢠The first successful surgical pulmonary embolectomy was performed in
1924(Kirschner a pupil of Trendelenburg in Germany), several decades before the
introduction of medical treatment for PE.
⢠Reserved for patients with absolute contraindications to thrombolysis and in
those in whom thrombolysis has failed to improve the hemodynamic status.
65. Treatment
Venous filters
⢠Venous filters (Mobin Uddin Umbrella) are usually placed in the infrarenal portion
of the inferior vena cava (IVC)
⢠Venous filters are indicated in patients with acute PE who have absolute
contraindications to anticoagulant drugs, and in patients with objectively
confirmed recurrent PE despite adequate anticoagulation treatment