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1.
RESEARCH POSTER PRESENTATION
DESIGN © 2015 www.PosterPresentations.com INTRODUCTION - Gastro-retentive drug delivery system (GRDDS) is particularly used to improve bioavailability of the drugs, which have narrow absorption window down in the levels of gastrointestinal tract and also to treat local disorders. In recent times scientific and technological advancement have been made in Research and Development of GRDDS. Gastro Retentive Drug Delivery System is an attempt to release drug slowly in GIT and maintain an effective drug concentration in systemic circulation for drugs that are easily absorbed from GIT and have short lives are eliminated quickly from the systemic circulation requiring frequent dosing to achieve optimum activity. GASTRORETENTIVE DRUG DELIVERY SYSTEMS 1.DENSITY 2. SIZE 3.FOOD INTAKE AND NATURE OF FOOD 4.CALORIC CONTENT 5.FREQUERNCY OF FOOD 6.GENDER 7.AGE FACTORS AFFECTING GRDDS DRUG SUITABLE FOR GRDDS 1.Drugs acting locally in the stomach Ex: Misoprotolol 2.Drugs with narrow absorption of window Ex : Cyclosporin , Methoxitrate 3.Drug that degrade the colon Ex: Ranitidine , Metformin 4.Drug absorb rapidly in GIT Ex: Tetracycline 5. Drug which are poorly soluble in alkaline pH Ex : Furosemide , Diazepam APPROACHES TO GASTRIC RETENTION TYPES OF GRDDS FIG: BIOADHESIVE SYSTEMS FIG:MAGNETIC SYSTEMS FIG: SWELLING AND EXPANDING SYSTEMS FIG: HIGH DENSITY SYSTEMS FIG: FLOATING SYSTEMS EVALUATION IN VITRO EVALUATION IN VIVO EVALUATION 1.BUOYANCY LAG TIME 2. FLOATING TIME 3.SPECIFIC DENSITY 4.SWELLING INDEX 5.WATER UPTAKE MARKETED FORMULATIONS 1.Floating Rafts have been used in treatment of gastric esophageal refluxease (GERD). 2.Novel adhesive material derived from fimbriae of bacteria are triec for better attachment to Gut. 3.Floating drug delivery concept can be used in development of anti reflux formulations . RECENT ADVANCES IN GRDDS CONCLUSION Gastroretentive drug delivery systems have emerged as a current approaches of enhancing bioavailability and controlled delivery of drugs .These systems not only provide controlled release of the drug but also present the drug in an absorbable form at the regions of optimal absorbtion. To design a successful GRDDS, it is necessary to take into consideration the physicochemical properties of the drug, physiological events in the GIT, formulation strategies, and correct combination of drug and excipients. REFERENCE 1. Prajapati etal. J Control Release 2013; 168: 151-165 2. K.Butchiah.2015.A Review on . GASTRORETENTIVE DRUGDELIVERY SYSTEMS, International Journal Of Innovative Pharmaceutical Sciences and research ,3(7),918-931 Abstract: Gastro-retentive drug delivery system (GRDDS) is particularly used to improve bioavailability of the drugs, which have narrow absorption window down in the levels of gastrointestinal tract and also to treat local disorders. Current approaches used for preparation of gastro-retentive drug delivery system offers limited functional features to control the floating behavior. Effective oral drug delivery depends upon factors such as Gastric Emptying, drug release from the dosage form. In recent times scientific and technological advancement have been made in Research and Development of GRDDS. It is one of the most novel approaches in area of the oral sustained release dosage forms. Hence worth a wide spectrum of dosage form have been developed for drugs which are unstable at intestinal pH, soluble in acidic pH. Gastro Retentive Drug Delivery System is an attempt to release drug slowly in GIT and maintain an effective drug concentration in systemic circulation for drugs that are easily absorbed from GIT and have short lives are eliminated quickly from the systemic circulation requiring frequent dosing to achieve optimum activity. The present review focuses on the currently utilized Gastro Retentive Drug Delivery Systems like Floating System, Swelling and Expanding System, Bioadhesive or mucoadhesive system, High Density System and other delayed gastric emptying devices.
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