Xenotransplantation involves transplanting organs, tissues or cells between species to treat human diseases. It could address the shortage of human donors but raises scientific, ethical and health concerns. Key issues include the risk of transmitting animal viruses to humans, the use of genetically modified pigs, impacts on animal welfare, and questions around how transplants may affect human identity or justify animal suffering. Religions generally accept xenotransplantation if it respects animal dignity and human life. Overall it remains uncertain if the benefits outweigh the risks, and alternative therapies using stem cells or organ printing should also be explored.
2. The term xenotransplantation (from the Greek ξένος, which means "foreign")
means the transplantation of organs, tissues or cells between organisms of
two different species.
One of the most promising approaches for the treatment of
serious diseases in humans (cancer, diabetes, liver failure and
Parkinson's disease).
The transplants of organs and tissues from animals to humans
could in fact eliminate the serious problem of donor shortages.
A worldwide shortage of organs for clinical implantation causes
approximately 20-35% of patients in need of replacement organs
to die on the waiting list.
In addition to scientific problems (rejection, health risk),
xenotransplantation also raises other questions that require
theological, anthropological, psychological and ethical nature.
3. Use of animals to improve human survival or health
Can we ethically justify the use of animals for xenotransplantation purposes?
Deciding whether animals are a simple tool and means aimed at the interest and well-being of man or animals are living beings with
interests, needs and desires and therefore must be considered and respected.
Do we also recognize the dignity of the animal?
Some argue that animals have similar rights to those deemed appropriate for humans. Animal protection has a legal status in
many countries.
Consequentialists may consider the suffering and death of an animal acceptable for the
betterment of a human patient, as they would judge the morality of an action primarily by its
end result. They would argue that the potential benefits and improved human welfare
from xenotransplantation may justify the loss of animal life.
However, this will never satisfy animal rights supporters; especially since while minimizing
the risk of acquired infections, animals must undergo greater suffering in the form of
isolation, monitoring and investigation. Furthermore, genetic modification can have both
immediate and long-term side effects on animals.
4. RELIGIOUS PERSPECTIVE
From a religious point of view, it is imperative to protect and preserve human life as a fundamental value.
Both Islam and Judaism prohibit the consumption of pork, but accept xenotransplantation on the basis that humans have
a higher place in the world and therefore have the right to use animals for their well-being as long as animals are treated
with respect.
Religions such as Hindu or Buddhist faiths allow the individual to make a choice.
The theme of xenotransplants could have a profound impact on religious communities that
perceive the self as sacred and the human being as separate from other animals.
The position of the Catholic Church on xenotransplantation was clarified and formalized in
the document entitled "The perspective of xenotransplantation, scientific aspects and ethical
considerations" in 2001. The Vatican considers xenotransplantation lawful as a therapeutic
operation in respect of the rights of the individual and the protection of society.
Christian, Jewish and Islamic religions have agreed that xenotransplantation does not
contravene the order of Creation and that the use of animals for the benefit of man is
acceptable.
5. Health risk
Xenotransplantation raises alarm: although a therapy of this kind is justified as a life-
saving procedure, we are obliged to be cautious, because we do not know the risks and
side effects.
«Retroviruses and prions of animal origin transmitted by xenotransplants can cause
diseases which, if spread to other individuals, risk causing large pandemics. It is therefore
advisable to evaluate the health risk that is run in relation to the alleged advantages of
xenotransplants and find solutions to prevent any risk that could threaten public health»
-Council of Europe, Recommendation 1399 (1999) on xenotransplantation
Xenozoonosis: transmission of infectious agents from one species to another.
Pigs contain sequences in
their DNA that encode
retroviruses (PERVs -
Porcine Endogenous
RetroViruses)
Over sixty pig infectious agents have been identified with the potential to cause disease in
humans.
Precautionary principle
Libertarian principle
6. Not all organs of the human body are equally an expression of the identity of the person:
- Some are purely functional
- Others add a strong symbolic charge to the function, connected with the subjectivity of the individual
- Other organs have an inseparable relationship with the personal identity of the subject, regardless of their
symbolic value: brain (neuropsychic structures of conscientious identity) and gonads (structures intended to
transmit the genetic traits of their own identity to the progeny).
There is the subjective aspect of accepting the use of animal organs, which is a question of a
cultural and psychological nature. Transplant medicine has shown that there are repercussions of
varying intensity on those who have received human organ transplants, especially if they are
symbolically significant organs (heart).
Xenotransplant and identity of the recipient
Body dimensions have a dramatic relevance in defining personal identity.
A serious issue is the protection of the identity of the human subject who receives an organ
of animal origin, in the doubt that the plant could objectively change the identity of the person.
7. Social and economic aspects
Xenotransplantation represents a form of possible therapy with a very high use of
health and economic resources.
Doubts about the reasonableness of the huge investments in xenotransplants
research, no one can yet say with certainty that they will become an ordinary and safe
surgical practice. The need to wisely allocate the available resources so as not to
penalize the development of other promising therapies. Relationship between research
costs and benefits.
Social justice. Protection of the right of pharmaceutical companies to have a return on
huge investments, a fundamental right of every person to have access to health care,
without discrimination or impediments due to excessive costs.
Ethical and legal debate on the patentability of life. Patentability of genetically
modified animal organisms to make them compatible with humans. Border between
discovery and invention. Under current European legislation, there are no legal
obstacles to the patentability of engineered animal organs intended for transplantation.
8. In January 2004, the Executive Council of the World Health Organization (WHO) published the draft
resolution EB113.R5 concerning "human organ and tissue transplantation", which contains guidelines
relating to xenotransplants and which has been subsequently accepted by all member states.
Xenotransplants, added with studies on biomechanical organs and stem cells,
represent an unfounded hope for the future of many patients.
Investing resources and hopes in this new
therapeutic perspective, in light of the
scientific uncertainties still present and the
urgent need to increase the availability of
organs to be transplanted. A serious ethical
commitment on the part of scientists
should also not neglect to explore
alternative therapeutic ways to
xenotransplantation, as many recent
discoveries in the field of genetics seem to
promise, as well as, in a longer perspective,
the therapeutic use of somatic stem cells.
Artificial organ transplantation
Organ printing
Science 22 Sep 2017
9. Bibliography
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