4. 2 Overview
A surfactant contains both a component and a water-
soluble component
Surfactants will diffuse in water and adsorb at
interfaces between air and water or at the interface
between oil and water, in the case where water is
mixed with oil. The water-insoluble hydrophobic
group may extend out of the bulk water phase, into the
air or into the oil phase, while the water-soluble head
group remains in the water phase. 。
Amphiphilic
Activity
Hydrophobic groups Hydrophilic groups
5. 2 Overview
The hydrophobic tails of the surfactant ions remain
inside the oil because they interact more strongly with
oil than with water.
The hydrophilic heads of the surfactant molecules
coating the micelle interact more strongly with water,
so they form a hydrophilic outer layer that forms a
barrier between micelles.
Hydrophobic tails
Hydrophilic Head
7. 1 Nonionic Surfactant
Water-solubility
The water-solubility of the oxygen
groups is the result of hydrogen
bonding.
Hydrogen bonding
Hydrogen bonding decreases with
increasing temperature, and the
water solubility of nonionic
surfactants therefore decreases
with increasing temperature.
10. 4 Amphoteric Surfactant
Cationic part
Primary, secondary, or tertiary
amines or quaternary
ammonium cations
Anionic part
Be more variable
Phospholipids phosphatidylserine
Phosphatidylethanolamine
Sphingomyelins
13. 2 Wetting agents
The purpose of adding surfactants is to increase the adhesion and
deposition of the drug, and to increase the activity of active
ingredient in the presence of moisture.