chemistry

2. CONTENT
• History
• Platinum complexes
• Cancer therapy
• Advantages
• Disadvantages
• Future updates
• Market availability
• Conclusions
• References

3. HISTORY
(cis platin)
• 1844 it was first created by Italian chemist Michele
Peyrone
• Barnett Rosenberg 1965
(carboplatin)
• 1971 by Bristol-Myers Squibb
(Oxaliplatin)
• 1976 World Health Organization's List of Essential
Medicines

4. PLATINUM COMPLEXES
 Cis-platinum
 Carbo-platinum
 Oxaliplatin
oxaliplatin
corboplatin

5. Cancer therapy

8. Advantages
 Charge variations
 Structure and bonding
 Matel ligind interaction
 Lewis acid properties
 Partially field d-orbital
 Redox activity
 Maximum survival rate
 Apoptosis
 Selective targets

9. Disadvantages
 Kidney damage
 Anemia
 Cough
 Platelet disorders
 Drug resistance
 Neurotoxicity
 Alimentary canal toxicity
 Hair lose

10. Future updates
 Dicycloplatin is a reformulation of the drug
carboplatin by Sopo-Xingda Pharmaceutical and
Bioplatin AG and is currently under clinical trial
evaluation in China.

11. Market availability
Platinum based Cancer Drug Market Segment by Type
covers:
 Cisplatin (Platino)
 Oxaliplatin (Paraplatin)
 Carboplatin (Eloxatin)
 Other

12. Conclusion
 Anti-cancer drug cisplatin and could be able to target cancer cells
without producing the ototoxic side-effects commonly
associated with this chemotherapy compound.
 Addition of steric bulk cis to the coordinating center of a
monofunctional DNA compound is one strategy that has
emerged in the development of new chemotherapy drug
candidates.
 Our results suggest that triamine-ligated complexes with this
form of steric bulk can exhibit nuclear compartmental targeting
and anti-cancer cell effects competitive with their heterocyclic
ligated counterparts.
 Further, although the triamine- and heterocyclic ligated
complexes produce auditory threshold shifts similar to cisplatin,
unlike cisplatin, the monofunctional compounds produce
virtually no effect on auditory hair cell density.

13. References
 1.Langer T, am Zehnhoff-Dinnesen A, Radtke S, Meitert J,
Zolk O. Understanding platinum-induced ototoxicity.
Trends Pharmacol Sci. 2013;34: 458–69. pmid:23769626
 2.Karasawa T, Steyger PS. An integrated view of cisplatin-
induced nephrotoxicity and ototoxicity. Toxicol Lett.
2015;237: 219–27. pmid:26101797
 And Cancer Therapy. Cancer. 2016;122: 1647–58.
pmid:26859792
 4.Lanvers-Kaminsky C, Zehnhoff-Dinnesen AA, Parfitt R,
Ciarimboli G. Drug-induced ototoxicity: Mechanisms,
Pharmacogenetics, and protective strategies. Clin
Pharmacol Ther. 2017;101: 491–500. pmid:28002638