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ANGINA PECTORIS
DEFINITION
A disease marked by brief sudden attack of chest pain or discomfort caused
deficient oxygenation of heart muscles usually due to impaired blood flow
to the heart.
Types of Angina:
o Stable Angina
o Unstable Angina
o Prinzmetal’s Angina (Variant Angina)
Stable Angina:
o Called as “Effort Angina”
o Discomfort is precipitated by activity.
o Minimal or no symptoms at rest.
o Symptoms relieved on rest/cessation of activity
Unstable angina:
o Also called “Crescendo angina”
o Acute coronary syndrome in which angina worsens
o Occurs at rest
o Severe and acute in onset
o Crescendo pain- pain increases every time
Prinzmetal’s Angina:
o Prinzmetal’s angina is a variant form of angina with normal
coronary vessels or minimal atherosclerosis.
o It is caused due to spasm of coronary artery.
Risk Factors:
MODIFIABLE
RISK FACTORS
NON MODIFIABLE
RISK FACTORS
o Tobacco use
o High Cholesterol or
TG levels.
o Lack of Exercise
o Obesity
o Stress
o Family History of
Heart Disease
o Older Age
o Diabetes
o High Blood Pressure
Pathophysiology:
Symptoms:
o Cardiovascular:
• Angina Pectoris
• Ischemia
• Low Cardiac Output
• Chest Pain
• ↓ Pulse Rate
• Diaphoresis- Excessive Sweating
• Dysarrithmias
Symptoms:
o Respiratory:
• Shortness of Breath
• Pulmonary Edema
• Heaviness of Chest
• Dyspnoea
• Fatigue
Symptoms:
o Genitourinary: Decreased Urine Output- indicate Cardiogenic
Shock.
o Gastrointestinal: Nausea & Vomiting.
o Skin: Cool, Clammy, Diaphoretic & Pale in Appearance.
Treatment:
o Aims:
• Relief of symptoms
• Slowing progression of the disease
• Reduction of future events like myocardial infarction
Drugs:
o For treatment of acute attacks :
• Organic nitrates/nitrites
o For prophylaxix:
• Organic nitrates
• Beta blockers
• Calcium channel blockers
• Ranolazine
• K+ channel opener- Nicorandil
 Heart rate
 Contractility
 Preload
 Afterload
 Coronary flow
 Regional
myocardial blood
flow
 O2 Demand  O2 Supply
-Blockers/Ca2+ channel
blockers
Nitrates/Ca2+ channel
blockers
Nitrates/Ca2+ channel
blockers/antithrombotic/ statins
HEART

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angina.pptx

  • 2. DEFINITION A disease marked by brief sudden attack of chest pain or discomfort caused deficient oxygenation of heart muscles usually due to impaired blood flow to the heart.
  • 3. Types of Angina: o Stable Angina o Unstable Angina o Prinzmetal’s Angina (Variant Angina)
  • 4. Stable Angina: o Called as “Effort Angina” o Discomfort is precipitated by activity. o Minimal or no symptoms at rest. o Symptoms relieved on rest/cessation of activity
  • 5. Unstable angina: o Also called “Crescendo angina” o Acute coronary syndrome in which angina worsens o Occurs at rest o Severe and acute in onset o Crescendo pain- pain increases every time
  • 6. Prinzmetal’s Angina: o Prinzmetal’s angina is a variant form of angina with normal coronary vessels or minimal atherosclerosis. o It is caused due to spasm of coronary artery.
  • 7. Risk Factors: MODIFIABLE RISK FACTORS NON MODIFIABLE RISK FACTORS o Tobacco use o High Cholesterol or TG levels. o Lack of Exercise o Obesity o Stress o Family History of Heart Disease o Older Age o Diabetes o High Blood Pressure
  • 9. Symptoms: o Cardiovascular: • Angina Pectoris • Ischemia • Low Cardiac Output • Chest Pain • ↓ Pulse Rate • Diaphoresis- Excessive Sweating • Dysarrithmias
  • 10. Symptoms: o Respiratory: • Shortness of Breath • Pulmonary Edema • Heaviness of Chest • Dyspnoea • Fatigue
  • 11. Symptoms: o Genitourinary: Decreased Urine Output- indicate Cardiogenic Shock. o Gastrointestinal: Nausea & Vomiting. o Skin: Cool, Clammy, Diaphoretic & Pale in Appearance.
  • 12. Treatment: o Aims: • Relief of symptoms • Slowing progression of the disease • Reduction of future events like myocardial infarction
  • 13. Drugs: o For treatment of acute attacks : • Organic nitrates/nitrites o For prophylaxix: • Organic nitrates • Beta blockers • Calcium channel blockers • Ranolazine • K+ channel opener- Nicorandil
  • 14.  Heart rate  Contractility  Preload  Afterload  Coronary flow  Regional myocardial blood flow  O2 Demand  O2 Supply -Blockers/Ca2+ channel blockers Nitrates/Ca2+ channel blockers Nitrates/Ca2+ channel blockers/antithrombotic/ statins HEART