3. • CRITERIA FOR DISEASE:
- Should be an important health problem (High Prevalence).
- Should have an early asymptomatic stage.
- Natural history should be understood.
- Test should be present to diagnose the disease before sign & symptoms.
- Facilities for confirmation of diagnosis should be available.
- Effective treatment should be present.
- Agreed on policy on whom to treat should be present.
- Good evidence the it reduce mortality and morbidity should be present.
- Expected benefits > Risks and costs.
4. • Criteria for Test:
- Reliable
- Valid
- Simple and inexpensive
- Very safe
- Acceptable to subjects
- Cost effective
- Exit Strategy
5. • Exit Strategy:
- Facilities for diagnosis and appropriate treatments should be
available for positive subjects.
6. - Test should be acceptable to aimed people .
Test should not be:
- Painful
- Unsafe
- Discomforting or embarrassing
• Acceptability:
7. ● Also known as Repeatability, Reducibility & Precision.
● Getting the same results, when the test repeated in same target
individuals in the same settings .
• Reliability:
8. - Observer variation
- Subject variation (Biological)
- Errors related to technical methods
• Causes of Unreliability:
10. • Also called within observer variation
- Same observer
- Two measurements
- Same Person
- Different results
• Intra-observer:
11. • Inter-observer:
Also known as between observer variation
- Same subject
- Different observers
Eg. :- Examination of blood smear for malarial
parasite by two observers
13. • Errors related to technical methods :
- Defective Instruments
- Error in calibration
- Faulty reagents
- Test itself might be inappropriate or unreliable
• When the errors are large, repeatability will be reduced, a
single test result may be unreliable.