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NREM SLEEPAROUSAL DISORDERS
Guided by-
Dr. Nimisha Mishra (M.D.)
Dr. Sunil k. Ahuja (M.D.)
Dr. Ambrish Mishra (M.D.)
Dr. Dheerendra Mishra (M.D.,DNB)
Presented by-
Dr. Jag Mohan Prajapati
JR 1
(Psychiatry)
OVERVIEW
INTRODUCTION
ORGANIZATION OF SLEEP
NREM AND REM CHARACTERISTICS
SLEEP DISORDER CLASSIFICATION
TOOLS FOR SLEEP MONITORING
SLEEP WALKING
SLEEP TERROR
CONFUSIONAL AROUSALS
SLEEP RELATED EATING DISORDER
INTRODUCTION
Sleep is a state of decreased awareness of environmental
stimuli that is distinguished from states such as coma or
hibernation by its relatively rapid reversibility.
It is also an essential component for good health and
optimal cognitive function.
For peak performance human need 8hrs sleep a day.
ORGANIZATION OF SLEEP:
NREM (75 percent)
Stage 1: 5 percent
Stage 2: 45 percent
Stage 3: 12 percent
Stage 4: 13 percent
REM (25 percent)
Source –synopsis
NREM STAGE BODILY
MOVEMENTS
OCULAR
MOVEMENTS
EMG EEG
N1 Light Persistent face and
limb tone with
repositioning every
15 to 20 minutes
Slow, rolling Continual
activity
Attenuation or
slowing of
alpha
(8-12 Hz
activity )
N2 Intermediate Persistent face and
limb tone with
repositioning every
15 to 20 minutes
Slow, rolling or
none
Further
reduction
Sleep spindles
and or K
complexes
N3 Slow wave,
Deep , Delta
Persistent face and
limb tone with
repositioning every
15 to 20 minutes
Absent Further
reduction
Slow wave(0.5-
2Hz)/Delta
activity
REM STAGE
Activated,
paradoxical
Flaccid, areflexic
conjugate paresis,
except for brief face
and limb movements
Rapid, ocular
movement
Silent with
artifact
Low amplitude,
mixed
frequency
CHARACTERISTICS OF NREM AND REM SLEEP
SLEEP ACTIVITY NREM SLEEP REM SLEEP
Eye Movement Slow Rapid
Body Movement Muscle relaxation Muscle twitches
Muscle tone Some tone in postural
muscles
Decreased
Vital signs Stable Fluctuating
Penile erection Rare Common
Dreams Rare Common
EEG Spindles , v-waves,
K-complexes, slow waves
Low voltage
Percentage –Adults 75-80 20-25
Percentage-infants 50 50
SLEEP DISORDER CLASSIFICATION
(ACCORDING TO DSM-5)
1. Insomnia Disorder
2. Hypersomnolence Disorder
3. Narcolepsy
4. Breathing-Related Sleep Disorders:
 Obstructive Sleep Apnea Hypopnea
 Central Sleep Apnea
 Sleep-Related Hypoventilation
5. Circadian Rhythm Sleep-Wake Disorders
a) Delayed sleep phase type
b) Advanced sleep phase type
c) Irregular sleep-wake type
d) Non-24-hour sleep-wake type
e) Shift work type
f) Unspecified type
6. Parasomnias
7. Non-Rapid Eye Movement Sleep Arousal
Disorders:
a. Sleep walking type
b. Sleep terror type
8. Nightmare Disorder
9. Rapid Eye Movement Sleep Behavior Disorder
10. Restless Legs Syndrome
11. Substance/Medication-Induced Sleep Disorder
TOOLS FOR SLEEP MONITORING
CLINICAL INTERVIEW
POLYSOMNOGRAPHY: Consists
EEG,EOG,EMG
MULTIPLE SLEEP LATENCY
TEST(MSLT)
ACTIGRAPHY
POLYSOMNOGRAPHY
Polysomnography is the continuous, attended, comprehensive recording of
physiological activity during sleep.
A polysomnogram is typically recorded at night and is 6 to 8 hours in
duration.
Brain waves activity, eye movements, submentalis electromyography activity,
nasal–oral airflow , nasal pressure, respiratory effort, oxyhemoglobin
saturation, heart rhythm, and leg movements during sleep are recorded.
Body position is usually noted and snoring sounds may
be recorded.
Brain wave activity, eye movements, and submentalis
electromyogram are important for identifying sleep
stages and CNS arousals.
Muscle tension and movements subside with deeper
sleep and can also be useful in the diagnosis of PLMD
and RLS.
MULTIPLE SLEEP LATENCY TEST
The patient is instructed to let him- or herself fall asleep; that is, to not resist
falling asleep. Electroencephalographic, electrooculographic , and submentalis
electromyography activity are recorded in order to determine sleep stage.
Every 2 hours, beginning 2 hours after morning awakening, a 20-minute nap
opportunity is provided.
The MSLT is indicated for diagnosing narcolepsy.
SLEEP WALKING
Repeated episodes of rising
from bed during sleep and
walking about. While
sleeping , the individual has a
blank staring face , is
relatively unresponsive and
can be awakened with great
difficulty.
Individual can engage in a
complex behaviour of semi
purposeful actions.
Sleepwalker
may interact
with the
environment
inappropriately
, resulting in
injury.
Disorders of
arousal ,
particularly
from deepest
stage of
sleep(N3).
Amnesia of the
episode is
present.
Very common in children , peak prevalence between 4
to 8 years.
Rare in adults . Familial pattern
“Specialized forms”: Sleep related eating and
Sexsomnia
TREATMENT
Often unnecessary
Psychoeducation and assurance
Safety issue
Medication: benzodiazepines
SLEEP TERRORS
Recurrent episodes of
abrupt terror arousals
from sleep , beginning
with a panicky scream.
There is intense fear and
signs of autonomic
hyperactivity-mydriasis ,
tachycardia , rapid
breathing and sweating.
Relative
unresponsiveness
to efforts of
others to comfort
the individual
during the
episode.
Recall of event , if
any , is minimal.
Risk of injury
during episode.
Occurs during first
third of nocturnal
sleep , deep
sleep(N3).
SLEEP TERRORS COMPARED TO
NIGHTMARES
Sleep Terrors Nightmares
Trigger Partial awakening from
deep sleep
Anxiety, fear; withdrawal
from medicines or drugs
Onset Early in night Anytime during night
Sleep stage N3 (slow-wave sleep) REM
Verbalization Crying, screaming Speaking words, conversing
Autonomic discharge Marked Little
Behavior after episode Returns to deep sleep
without recall
Awakens, recalls dream
content, fearfulness
SOURCE -KAUFMAN
CONFUSIONALAROUSALS
It is a milder form of NREM Sleep Parasomnias.
It is common in young children.
The child will typically partially awaken from sleep and
sit up.
The episodes are marked by confusion but usually the
child lies back down and resumes sleep.
SLEEP-RELATED EATING DISORDER
1.The patient has recurrent sleep-related eating episodes.
2.The patient consumes peculiar foods, food
combinations, or toxic substances; creates a hazard or is
injured during food preparation (e.g., starting a fire on
the stove); or the patient suffers adverse health
consequences from the sleep-related eating (e.g.,
substantial weight gain).
3.The eating is associated with partial or complete
amnesia and general lowering or loss of conscious
awareness.
4.The eating is associated with partial or complete
amnesia and general lowering or loss of conscious
awareness
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NREM SLEEP AROUSAL DISORDERS (2021_09_28 07_19_03 UTC).pptx

  • 1. NREM SLEEPAROUSAL DISORDERS Guided by- Dr. Nimisha Mishra (M.D.) Dr. Sunil k. Ahuja (M.D.) Dr. Ambrish Mishra (M.D.) Dr. Dheerendra Mishra (M.D.,DNB) Presented by- Dr. Jag Mohan Prajapati JR 1 (Psychiatry)
  • 2. OVERVIEW INTRODUCTION ORGANIZATION OF SLEEP NREM AND REM CHARACTERISTICS SLEEP DISORDER CLASSIFICATION TOOLS FOR SLEEP MONITORING SLEEP WALKING SLEEP TERROR CONFUSIONAL AROUSALS SLEEP RELATED EATING DISORDER
  • 3. INTRODUCTION Sleep is a state of decreased awareness of environmental stimuli that is distinguished from states such as coma or hibernation by its relatively rapid reversibility. It is also an essential component for good health and optimal cognitive function. For peak performance human need 8hrs sleep a day.
  • 4. ORGANIZATION OF SLEEP: NREM (75 percent) Stage 1: 5 percent Stage 2: 45 percent Stage 3: 12 percent Stage 4: 13 percent REM (25 percent) Source –synopsis
  • 5. NREM STAGE BODILY MOVEMENTS OCULAR MOVEMENTS EMG EEG N1 Light Persistent face and limb tone with repositioning every 15 to 20 minutes Slow, rolling Continual activity Attenuation or slowing of alpha (8-12 Hz activity ) N2 Intermediate Persistent face and limb tone with repositioning every 15 to 20 minutes Slow, rolling or none Further reduction Sleep spindles and or K complexes N3 Slow wave, Deep , Delta Persistent face and limb tone with repositioning every 15 to 20 minutes Absent Further reduction Slow wave(0.5- 2Hz)/Delta activity REM STAGE Activated, paradoxical Flaccid, areflexic conjugate paresis, except for brief face and limb movements Rapid, ocular movement Silent with artifact Low amplitude, mixed frequency
  • 6.
  • 7. CHARACTERISTICS OF NREM AND REM SLEEP SLEEP ACTIVITY NREM SLEEP REM SLEEP Eye Movement Slow Rapid Body Movement Muscle relaxation Muscle twitches Muscle tone Some tone in postural muscles Decreased Vital signs Stable Fluctuating Penile erection Rare Common Dreams Rare Common EEG Spindles , v-waves, K-complexes, slow waves Low voltage Percentage –Adults 75-80 20-25 Percentage-infants 50 50
  • 8. SLEEP DISORDER CLASSIFICATION (ACCORDING TO DSM-5) 1. Insomnia Disorder 2. Hypersomnolence Disorder 3. Narcolepsy 4. Breathing-Related Sleep Disorders:  Obstructive Sleep Apnea Hypopnea  Central Sleep Apnea  Sleep-Related Hypoventilation
  • 9. 5. Circadian Rhythm Sleep-Wake Disorders a) Delayed sleep phase type b) Advanced sleep phase type c) Irregular sleep-wake type d) Non-24-hour sleep-wake type e) Shift work type f) Unspecified type
  • 10. 6. Parasomnias 7. Non-Rapid Eye Movement Sleep Arousal Disorders: a. Sleep walking type b. Sleep terror type 8. Nightmare Disorder 9. Rapid Eye Movement Sleep Behavior Disorder 10. Restless Legs Syndrome 11. Substance/Medication-Induced Sleep Disorder
  • 11. TOOLS FOR SLEEP MONITORING CLINICAL INTERVIEW POLYSOMNOGRAPHY: Consists EEG,EOG,EMG MULTIPLE SLEEP LATENCY TEST(MSLT) ACTIGRAPHY
  • 12. POLYSOMNOGRAPHY Polysomnography is the continuous, attended, comprehensive recording of physiological activity during sleep. A polysomnogram is typically recorded at night and is 6 to 8 hours in duration. Brain waves activity, eye movements, submentalis electromyography activity, nasal–oral airflow , nasal pressure, respiratory effort, oxyhemoglobin saturation, heart rhythm, and leg movements during sleep are recorded.
  • 13. Body position is usually noted and snoring sounds may be recorded. Brain wave activity, eye movements, and submentalis electromyogram are important for identifying sleep stages and CNS arousals. Muscle tension and movements subside with deeper sleep and can also be useful in the diagnosis of PLMD and RLS.
  • 14. MULTIPLE SLEEP LATENCY TEST The patient is instructed to let him- or herself fall asleep; that is, to not resist falling asleep. Electroencephalographic, electrooculographic , and submentalis electromyography activity are recorded in order to determine sleep stage. Every 2 hours, beginning 2 hours after morning awakening, a 20-minute nap opportunity is provided. The MSLT is indicated for diagnosing narcolepsy.
  • 15. SLEEP WALKING Repeated episodes of rising from bed during sleep and walking about. While sleeping , the individual has a blank staring face , is relatively unresponsive and can be awakened with great difficulty. Individual can engage in a complex behaviour of semi purposeful actions.
  • 16. Sleepwalker may interact with the environment inappropriately , resulting in injury. Disorders of arousal , particularly from deepest stage of sleep(N3). Amnesia of the episode is present.
  • 17. Very common in children , peak prevalence between 4 to 8 years. Rare in adults . Familial pattern “Specialized forms”: Sleep related eating and Sexsomnia
  • 18. TREATMENT Often unnecessary Psychoeducation and assurance Safety issue Medication: benzodiazepines
  • 19. SLEEP TERRORS Recurrent episodes of abrupt terror arousals from sleep , beginning with a panicky scream. There is intense fear and signs of autonomic hyperactivity-mydriasis , tachycardia , rapid breathing and sweating.
  • 20. Relative unresponsiveness to efforts of others to comfort the individual during the episode. Recall of event , if any , is minimal. Risk of injury during episode. Occurs during first third of nocturnal sleep , deep sleep(N3).
  • 21. SLEEP TERRORS COMPARED TO NIGHTMARES Sleep Terrors Nightmares Trigger Partial awakening from deep sleep Anxiety, fear; withdrawal from medicines or drugs Onset Early in night Anytime during night Sleep stage N3 (slow-wave sleep) REM Verbalization Crying, screaming Speaking words, conversing Autonomic discharge Marked Little Behavior after episode Returns to deep sleep without recall Awakens, recalls dream content, fearfulness SOURCE -KAUFMAN
  • 22. CONFUSIONALAROUSALS It is a milder form of NREM Sleep Parasomnias. It is common in young children. The child will typically partially awaken from sleep and sit up. The episodes are marked by confusion but usually the child lies back down and resumes sleep.
  • 23. SLEEP-RELATED EATING DISORDER 1.The patient has recurrent sleep-related eating episodes. 2.The patient consumes peculiar foods, food combinations, or toxic substances; creates a hazard or is injured during food preparation (e.g., starting a fire on the stove); or the patient suffers adverse health consequences from the sleep-related eating (e.g., substantial weight gain).
  • 24. 3.The eating is associated with partial or complete amnesia and general lowering or loss of conscious awareness. 4.The eating is associated with partial or complete amnesia and general lowering or loss of conscious awareness
  • 25.