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Transcript

  • 1.  
  • 2. MADE BY Mehtab shah B.S MT 3 RD YEAR
  • 3. WHAT IS DENGUE FEVER?
    • It is an infectious disease carried by mosquitoes and any of four related dengue viruses.
    • The disease is also called
    • “ BREAK-BONE” fever.
    • It some times causes severe joint and muscle pain that feels like bone are breaking.
  • 4. CLASSIFICATION DENGUE CLASSIC DENGUE HEMORRHAGIC DENGUE
  • 5. Dengue hemorrhagic fever
    • Dengue hemorrhagic fever is a severe, often fatal, complication of Dengue fever.
    • Serious life-threatening condition.
    • Frequently children and others are affected whom previously infected with one serotype or strain of dengue virus and subsequently become reinfected with a different serotype or strain.
    • The secondary immune response leads to the formation of virus-antibody immune complexes which activate complement.
  • 6. CONTD………..
    • These complements are causing vascular damage and dissaminated intravascular coagulation (DIC) with spontaneous bleeding.
    • In some patients, DHF progresses to circulatory collapse, referred as dengue shock syndrome (DSS).
  • 7. EPIDIOMOLOGY
    • Dengue fever is found mostly during and shortly after the rainy season in tropical and sub tropical areas of
    • Africa
    • South East Asia and China
    • India
    • Middle East
    • Caribbean and Central and South America
    • Australia and the South and Central Pacific
  • 8. VIRUS CLASSIFICATION
    • GROUP : IV
    • FAMILY :Flaviviridea
    • Genus :Flavivirus
    • Specie :Dengue Virus
  • 9. PATHOGENESITY
    • Dengue is a four types.
    • DEN-1, DEN-2, DEN-3, DEN-4, cause dengue (DEN) and dengue hemorrhagic fever (DHF).
    • These viruses are transmitted by the bite of Aedes mosquitoes.
  • 10. Replication and transmission
    • Virus transmitted to human by mosquito bite.
    • Virus replicate in target organs.
    • Virus infects white blood cells and lymphatic tissues.
    • Virus released and circulates in blood.
  • 11. CONTD>>>>>>>>
    • Two main species of mosquito. Aedes aegypti Aedes albopictus
    • Dengue is not contagious from person to person.
    • Aedes mosquitoes usually bites during day time.
  • 12. SYMPTOMS
    • Dengue usually start with fever within 4-7 days after been bitten by an infected mosquitoes.
  • 13. CONTD>>>>>>>
    • High fever
    • Severe headache
    • Pain in eyes
    • Severe joint and muscle pain
    • Nausea and vomiting
    • Enlarged lymph glands
  • 14. CONTD>>>>>>>>
    • Some times;
    • > Abdominal pain
    • > Vomiting
    • Occasionally;
    • > Hemorrhagic symptoms
  • 15. CONTD>>>>>>>>>>
    • Virus enter into the blood circulation by multiplication of virus in the reticuloendothelial system.
    • Leucopenia is the most infectious cause.
  • 16. Diagnosis
    • The diagnosis of dengue is usually made clinically.
    • The classis picture is high fever with no localizing source of infection.
    • A petechial rash with thrombocytopenia and relative leucopenia.
    • Low platelet and white blood cell count
    • Blood test showing blood containing antibodies to the virus.
  • 17. DENGUE TEST
    • Dengue test performed by the immunochromatographic method using the BIAS-3 (bi-directional immuno assay system) dengue IgG/IgM kit.
    • BIAS-3; two step assay for the differential detection of IgG or IgM antibodies to dengue virus in serum or whole blood.
  • 18. TEST PRINCIPLE
    • This test is the membrane based screening test to differentially detect the presence of antibodies to dengue virus.
    • Lateral flow immunochromatographic type assay.
    • Once the sample is added to the sample pad along with diluents the mixture passes bi-directionally through two antibody binding complexes which then binds the immunoglobulin in the sample.
  • 19. CONTD>>>>>>> The complex passes over the immobilized antigens on the membrane, if any antibodies to dengue (IgG or IgM) are present the antigens capture them in turn. This produces a pink/purple band in the test-zone of the device. The remaining complex continues to migrate to a control area on the test device and produces a pink/purple band each control area. This control bands indicate that the test has been performed properly.
  • 20. Interpretation
    • Negative Only one pink/purple band appears in the Control areas of the BIAS test device
  • 21. CONTD>>>>>>>>
    • Positive One or Two pink/purple bands appear in the Test area of the BIAS test device and one line each in the Control area of the test device
  • 22. CONTD>>>>>>>>>>>
    • SECONDARY DENGUE INFECTION
    • IgG Positive
    • IgG and IgM Positive PRIMARY DENGUE INFECTION
    • IgM positive
  • 23. Treatment
    • There is no specific treatment for classic dengue fever, and most people recover within two weeks
    • To help with recovery health care experts recommend
    • Getting plenty of bed rest
    • Drinking lots of fluid
    • Give medicine to reduce fever
  • 24. Prevention
  • 25.  
  • 26. THANK YOU ATTENTION?