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Reverse Vaccinology




   Kapita Selekta Bioteknologi
     Wage Indrya Nugraha
            21111017
http://www.wired.com/science/discoveries/news/2008/05/dayintech_0514#


  Edward Jenner 1796
Louis Pasteur 1886




               http://www.icollector.com/Louis-Pasteur_i9688850
Reverse Vaccinology
1. Analisis komputer (In Silico)
2.Identifikasi antigen
3. Animal test
4. Molecular epidemology
5. Uji klinis
6. Ijin dari regulator
7. Rekomendasi
8. Implementasi (uji klinis tahap
IV dinyatakan aman)




 Rappuoli R. (2010). Reverse vaccinology. Immunity
 Review 33 : 530-541.
Vaccinomic
Reverse Vaccinology
Biology Molekuler, Immunology, Genomic
(-Omic), Komputasi & Bioinformatic
Reverse Vaccinology
Epitope ; bagian dari
molekul antigen yang
mampu berinteraksi
dengan antibodi
secara spesifik
membentuk sistem
kekebalan tubuh.
Reverse Vaccinology
Epitope Linier &
Epitope Non
Linier
Reverse Vaccinology
Reverse Vaccinology
Reverse Vaccinology
Bioinformatic
Public Domain, Desktop Application (Free
access-proprietary) :
IEDB, ELLIPRO, GENEIOUS, CLC-BIO, EPIVAX,
VAXIGN
Vaccinomic
Reverse Vaccinology
Grup B Meningococcus, Malaria, Tuberculosis,
Syphilis, Hepatitis-C
TERIMAKASIH

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Reverse vaccinology