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Lamda phage

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lytic cycle lysogenic cycle

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Lamda phage

  1. 1. Life cycle of  λ phage Presented by: Minhaz Ahmed BBI11014 Integrated M.Sc 3rd  semester,MBBT, Tezpur University, Assam
  2. 2. CONTENTS  Introduction  How genome is transferred  Lytic cycle and lysogenic cycle  Life cycle  Lytic or lysogenic?
  3. 3. What is lambda phage?  It is a bacterial virus, or bacteriophage , that infects the bacterial species Escherichia coli.  This virus is a temperate phage.  Temperate phages are basically bacteriophages which can choose between a lytic and lysogenic pathway of development. SOURCE:classes.midlandstech.edu
  4. 4. The viral DNA exists as a separate molecule within the bacterial cell.  Replicates separately from the host bacterial DNA.  Viral DNA integrates with bacterial DNA. Replicates with the host DNA
  5. 5. How it penetrates: It binds to the target E. coli cell, via J protein in the tail tip that interacts with the maltoporin of E. coli and injects its linear genome. TAIL FIBRE TAIL HEAD 1 DNA COLLAR BASE PLATE DNA of E. coli MALTOPORIN in E. coli 2 E. coli
  6. 6. LIFE CYCLE : SOURCE: Pearson Education 2004
  7. 7. Lytic or lysogenic? 1.lytic life cycle: occurs in cells with sufficient nutrients, protease activity is high, which breaks down cII. 2.Lysogenic life cycle: In cells with limited nutrients, protease activity is low, making cII stable.  Computer modeling and simulation suggest that random processes during infection drive the selection of lysis or lysogeny within individual cells. However, recent experiments suggest that physical differences among cells, that exist prior to infection, predetermine whether a cell will lyse or become a lysogen.
  8. 8. THANK YOU

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