Physiochemical factors influencing formulaon

SEMINAR ON PHYSIOCHEMICAL FACTORS INFLUENCING FORMULATION PRESENTED BY:- VBM ROLL :- 12 YEAR-2010-2011

PREFORMULATION ,[object Object],[object Object]

DIRECT BENEFITS ,[object Object],[object Object],[object Object],[object Object]

CONTENTS:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

B. SOLUBILITY ANALYSIS 1) Ionization constant 2) Solubilization. 3) Partition Coefficient 4) Thermal effect 5) Common ion effect. 6) Dissolution. C. STABILITY ANALYSIS 1) Solid State Stability. 2) Solution State Stability

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CHRYSTALLINITY AND POLYMORPHISM ,[object Object],BMCP ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

POLYMORPHISM:- ,[object Object],[object Object],[object Object]

HYGROSCOPICITY ,[object Object],[object Object],[object Object]

PARTICAL SIZE AND SURFACE AREA ,[object Object],[object Object],[object Object],[object Object],[object Object]

FLOW PROPERTY AND BULK DENSITY ,[object Object]

IONIZATION CONSTANT(pKa):- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

METHODS TO DETERMINE pKa ,[object Object],[object Object],[object Object],[object Object],[object Object]

SOLUBILIZATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

PARTITION COEFFICIENT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

THERMAL EFFECT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

COMMO N ION EFFECT:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Solid drug in GI fluid Solution of drug in GI fluid Drug in systemic circulation Dissolution Absorption Kd Ka When Kd<<<<<Ka absorption is dissolution rate limited

[object Object],[object Object],[object Object],[object Object],[object Object]

STABILITY ANALYSIS ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Chemical Characteristic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

FACTORS AFFECTING OXIDATION PROCESS ,[object Object],[object Object],[object Object],[object Object],[object Object]

PREVENTION OF OXIDATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HYDROLYSIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PREVENTION OF HYDROLYSIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PHOTOLYSIS ,[object Object],[object Object],[object Object]

PHOTODECOMPOSITION PATHWAY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object]

PREVENTION OF PHOTODECOMPOSITION:- ,[object Object],[object Object],[object Object],[object Object],[object Object]

RACEMIZATION ,[object Object],[object Object],[object Object]

POLYMERIZATION ,[object Object],[object Object],[object Object],[object Object]

ISOMERIZATION ,[object Object],[object Object],[object Object],[object Object],[object Object]

DECARBOXYLATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

REFERENCES: ,[object Object],[object Object],[object Object],[object Object]

Physiochemical factors influencing formulaon

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