Nervacin® Cream is a natural topical cream for treating neuropathic pain. It contains several plant extracts and essential oils that have been shown to reduce neuropathic pain through analgesic, anti-inflammatory, and neuroprotective mechanisms. Studies demonstrate that ingredients such as Ginkgo biloba, evening primrose oil, and capsaicin can protect nerves, increase blood flow, and deactivate pain receptors. The global neuropathic pain treatment market is expected to grow significantly over the next decade. Nervacin® Cream offers a unique formula and superior alternative for relieving neuropathic pain.

1. Novel Approach for neuropathic pain
Nervacin® Cream

2. Neuropathic pain ... Facts
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Neuropathic pain is usually caused by nerve damage from an injury or a
medical problem.
 Neuropathic pain symptoms can include burning, tingling sensation or
deep aching pain.
 Neuropathic pain is hard to treat.
 The prevalence of diabetic neuropathy is (28%) in patients with type-1
DM and (50%) in those with type-2 DM.
 Control of modifiable risk factors can reduce the risk of neuropathy
development, like good glycemic control, normal blood pressure and
absence of dyslipidaemia.

3. Neuropathic pain market size (Present & Future)
The global market size for neuropathic pain treatment products
is estimated to grow at (CAGR) of (9.1%) from 2021 to 2030
2021 2022 ........... 2030
2.4 billion. US $ 2.6 billion US $ 4.9 billion US $

4. Nervacin® Cream
Nervacin® Cream is a natural, scientifically
approved with high efficacy formula for the
treatment of neuropathic pain.

5. Nervacin® Cream
Active ingredients
Oenothera biennis (Evening primrose) oil,
Ginkgo biloba leaf ext., Capsicm frutescens
fruit ext., Acorus calamus root ext., Sage
(Salvia officinalis) ext., Eucaleptus globules
leaf oil, pelargonium graveolens (Geranium)
oil, Lycopodium clavatum ext.

6. Nervacin® Cream
Activity / Ingredient / Mechanism of action

7. Neuropathic pain killer effects
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Ginkgo biloba
- It protect disturbed axonal transport and alteration of peripheral nerves.
- It blocks induction of iNOS and release of NO, and NO known to play a significant role
in nociceptive processing in the spinal cord.
Evening
primrose oil
Increase in membrane fluidity, increased availability of arachidonic acid/diacylglycerol to stimulate nerve Na-
Ka-ATPase activity and compensate for the deficit in this enzyme with diabetes.
Also it acting as a substrate for production of vasodilator prostanoids such as prostacycline to improve nerve
perfusion.
Eucaleptus
oil
prevention of sensitization of the nociceptor, down regulation of sensitized
nociceptor at peripheral and/or central level.
Geranium
Oil
Inhibits Nitric oxide production, as well as expression of the proinflammatory enzymes cyclooxygenase-s (COX-
2) and induced nitric oxide synthase (iNOS) in primary culture and activated microglial cells, thus geranium oil
might be beneficial in the prevention/treatment of neurodegenerative diseases when neuro-inflammation is part
of the pathophysiology
Capsaicin
Inactivation of voltage – gated Na channels and direct pharmacological desensitization of
plasma membrane (TRPV1) receptors, which leads finally to nerves desensitization.

8. Anti-inflammatory and analgesic effect
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Acorus
calamus
Analgesic effect due to the involvement of endogenous prostaglandins.
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Geranium oil Inhibits the LPS-elicited expression of the induced proinflammatory enzyme COX-2 and
iNOS.
Sage oil
Inhibition of NO and PGE2, NF-kB transcription activity.
Lycopodium
clavatum
: It has Lycopodine and works as potent anti-inflammatory.
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9. Enhancement of blood circulation
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Capsaicin capsaicin stimulates a specific population of sensory nerves (CSPAs) in the skin that possess
the capsaicin receptor, eliciting a local release of vasoactive neurotransmitters from their
terminal nerve endings, which increase the blood circulation in the area.
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Ginkgo
biloba
It blocks induction of iNOS and release of NO, and NO known to play a significant role in
enhancement of blood circulation

10. Nervacin® Cream
Why it is a valuable brand?
Unique and
superior
formula
Few
competitor
brands
Well-
studied
ingredients

11. Nervacin® Cream ...
The story of efficacy and safety
Nervacin® Cream is a unique and innovative formula with
approved efficacy.
 Nervacin® Cream augmented neuropathic pain reduction is
provided by more than one ingredient in its composition
where their effect has been scientifically studied.
 Nervacin® Cream leads to pain reduction by its analgesic,
anti-inflammatory and neuro-protection formulation
properties.
 Nervacin® Cream formula provide insulation, enhancement
of blood circulation and relieving of aching muscle and stress
in the affected area.
 Nervacin® Cream is a natural formula with an excellent
safety profile.
 Nervacin® Cream is considered as a cost effective brand.

12. Nervacin® Cream ...
References (Studies):
Clinical and electrophysiological efficacy of leaf extract of
Ginkgo biloba in subjects with diabetic sonsorimotor
polyneuropathy (Topical Journal of pharmaceutical Research – 2016)
 Capsaicin for neuropathic pain: Linking traditional medicine
and molecular biology (Euro Neurol -2012)
 Inhibitory effect of capsaicin on voltage-gated potassium
channels by TRPV1 independent pathway (Cell Mol Neurobiol -
2014).
 Neuroprotective effect of saponin – rich extract of Acorus
calamus of chronic constriction injury of siatic nerve-induced
neuropathic pain (Journal of Ethnopharmacology-2012)
 Analgesic and anti-inflammatory effects of essential oils of
Eucaleptus (Journa of Ethnopharmacology-2003)

13. Nervacin® Cream ...
References (Studies):
The effect of evening primrose oil on nerve function and
capillarization in streptozotocin-diabetic rats (Br J pharmacol-
1993)
Anti-neuroinflammatory effects of geranium oil in microglial
cells (Journal of functional foods-2010)
 Essential oil composition of anti-inflammaory activity of
salvia officinalis in Murin macrophages (Topical Journal of
pharmaceutical Research-2014).

14. THANK YOU