THERAPEUTIC INTERVENTION OF NEUROPATHIC PAIN WITH INNOVATIVE TARGETS, It is used to the know about the the innovative targets used for the neuropathic pain for farther research to implement the new drugs.

1. PRESENTED BY:
DEPARTMENT PHARMACOLOGY
SEVEN HILLS COLLEGE OF PHARMACY

2. NEUROPATHIC PAIN
• Neuropathic pain is defined as damage or disease affected the
somatosensory nervous system.
• Many peoples are affects worldwide.
• Neuropathic pain was characterized by three types. There are
NEUROPATHIC
PAIN
peripheral
neuropathic pain
central
neuropathic pain
mixed (peripheral
and central)

3. PERIPHERAL NEUROPATHIC PAIN: Peripheral neuropathic pain is defined as
'pain caused by a lesion or disease of the peripheral somatosensory nervous
system'.
CENTRAL NEUROPATHIC PAIN: Central neuropathic pain is defined as 'pain
caused by a lesion or disease of the central somatosensory nervous system‘.
 Neuropathic pain was characterized in patients suffering from
Cancer
AIDS,
long standing diabetes
lumbar disc syndrome
TYPES OF NEUROPATHIC PAIN

4. DRUGS IN CURRENT USE :
• Amitriptyline
• Gabapentin
• Pregabalin
• Lyrica (pregabalin)
• Cymbalta (duloxetine)
• Neurontin (gabapentin).
• Lidoderm (5% lidocaine patch).
• Qutenza (8% capsaicin patch).

5. MOLECULAR TARGETS
NEUROPATHIC
PAIN
BDNF
P2X 4R
TRPV1
Na+
Channel

6. SODIUM CHANNELS ( Na+ CHANNELS)
• voltage-gated sodium channels there are several channels that have been
linked to neuropathic pain.
• Namely Nav1.3, Nav1.7, Nav1.8 and Nav1.9.
• Alterations in the expression, distribution, kinetics, and voltage-dependence.
BDNF (BRAIN-DERIVED NEUROTROPHIC FACTOR )
• BDNF is involved in the central sensitization and synaptic plasticity in the
spinal cord.
• It has been shown to contribute to the development and maintenance of
neuropathic pain by activation of the dorsal horn NR2B-containing NMDA
(NMDA-2B) receptors.

7. TRANSIENT RECEPTOR POTENTIAL VANILLOID 1 (TRPV1)
Transient receptor potential
vanilloid 1 (TRPV1), a non-
selective cation channel
expressed by sensory
neurons, functions to
perceive external stimuli,
including heat or capsaicin

8. P2X 4R
P2X4R is an
important target for
pharmacological
intervention for
neuropathic pain in
the spinal cord .

9. CONCLUSION
Sodium Channels Like Nav1.3, Nav1.7, Nav1.8 And Nav1.9, BDNF,
TRPV1, P2X4 receptors are considered as innovative targets for
neuropathic pain which may helps in new drug discovery process with
respected to pharmacological interventions.

10. REFERENCE
• Singh Jaggi, A., & Singh, N. (2011). Therapeutic Targets for the
Management of Peripheral Nerve Injury- Induced Neuropathic Pain. CNS &
Neurological Disorders - Drug Targets, 10(5), 589–609.
• Carrasco, C., Naziroǧlu, M., Rodríguez, A. B., & Pariente, J. A.
(2018). Neuropathic Pain: Delving into the Oxidative Origin and the
Possible Implication of Transient Receptor Potential Channels. Frontiers in
Physiology, 9.
• Tsuda, M., Masuda, T., Tozaki-Saitoh, H., & Inoue, K. (2013). P2X4
receptors and neuropathic pain. Frontiers in Cellular Neuroscience, 7.