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Professional Scientific product profile - KenaLeen Cream.pdf
1. Ke n a L e e n ® C r e a m
S c i e n t i f i c P r o d u c t
P r o f i l e
2. Simple Slide Deck 2
V i t i l i g o … S c i e n t i f i c fa c t s
◼ Vitiligo is an autoimmune disease , is a pigmentation disorder in which
melanocytes in the skin are destroyed.
◼ Vitiligo can appear at any age, usually first appear between age of 20 and 30.
◼ Vitiligo affects both genders and all races equally.
◼ Vitiligo seems to be somewhat more common in people with certain
autoimmune diseases.
◼ Vitiligo sometimes runs in families (Genetics).
◼ Nearly (1%) of global population affected with vitiligo.
3. Simple Slide Deck 3
V i t i l i g o t r e at m e n t m a r ke t s i ze
Global vitiligo treatment market size was valued at (1243.8 million) in 2018 and is
projected to reach (1944.5 million) in 2026, exhibited a CAGR of (5.8%) in its
forecast period (Fortune Business Inside)
1243.8
million
2018
4. Depegmented patches
develop on only one side of
the body
Depegmentation occurs
symmetrically on both sides
of the body
Vitiligo Patterns
Focal Segmental Generalized
Depegmentation limited to
one or few areas
5. 2
1
4 3
5
Vitiligo Treatment
It is a kind of skin
grafting.
Combination between two
ot more treatment option
like a combination
between PUVA &
Calcineurin inhibitors …
Corticosteroids, Topical
PUVA, Calcineurin
inhibitors, Vitamin D
analogue and
Pseudocatalase.
NB-UVB and
monochromatic excimer.
Corticosteroids, psoralen,
immunosuppressent and
biological drugs
S u r g i c a l t h e r a p y
C o m b i n e d t h e r a p y
T o p i c a l t h e r a p y
P h o t o t h e r a p y
S y s t e m i c t h e r a p y
7. KenaLeen® C re a m
I n n o v a t i v e f o r m u l a
The trusted and evidence-based scientific
approach for the treatment of Vitiligo,
K e n a L e e n ® C r e a m formula is the big
story behind the nature.
8. KenaLeen® C re a m
K e y i n g r e d i e n t s
Cocos Nucifera Oil, Psoralea Corylifolia extract,
Berberis vulgaris Root Extract, Picrorhiza Kurroa
Root Extract, Melaleuca Alternifolia (Tea Tree) Leaf
Oil, Emu oil, Tocopherol (Vitamine E)
9. Simple Slide Deck 9
KenaLeen® C re a m
Active ingredient / Mechanism of action
1
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Picrorhiza kurroa:
-Modulate the immune
system, by stimulating the
cell-mediated and humoral
components of the immune
system as well as
phgocytosis.
Coconut oil: It is rich in Zn
increased Tc cells.
Tea tree oil: Inhibits NF-kB
signaing activation and levels
of cytokine production by
macrophage-like cell lines.
Immunomodulatory
effect
Psoralea corylifolea:
Inhibition of epiderma DNA
synthesis and therby cell
division, which increase in
expression of tyrosinase
then induce melanogenesis.
Photosensitizing and
melanogenesis
induction
2 3 4
Potent anti-oxidant
(Anti-free-radical)
effect
Picrorhiza Kurroa: Inhibits
the generation of oxygen
anions and to scavenge free
radicals.
Berberry root extract:
Decrease the level of H2O2
and enhance the
melanogenisis.
Coconut oil: It has phenolic
compounds and flavonoids
with high anti-oxidant effect,
scavenging nitic oxide
radicals and alkaline
dimethyl sulfoxide.
-.
Skin Nutrients
Coconut oil: it contains
vitamines like C, A, E, K
and minerals like copper,
zinc, phosphorus,
magnesium and selenium
which are of big benefits
to vitiligo skin.
10. Simple Slide Deck 10
KenaLeen® C re a m
The uniqueness and superiority power
No
.
Therapeutic Category /
Product
Active Ingredient Mechanism of action Mean Response Rate Safety Profile
1 Synergistic / KenaLeen® - Psoralea Corylifolia
seed extract
- PicrorhizaKurroa Root
Extract
- Berberis vulgaris Root
Extract
- Cocos Nucifera Oil
- Photosensitizing and
mealnogenesis
induction.
- Immunomodulatory
effect.
- Anti-free radical (Potent
antioxidant) effect.
- Specified skin Nutrients.
➢ 72% Safe
2 Corticosteroids / Potent and
Moderate corticosteroids
- Clobetasol
- Betamethason.
- Modulation of the
immune response.
~ 49% Narrow safety profile (for
prolong use)
3 Calcineurin Inhbitor /
Pimecrolimus and Tacrolimus
- Pimecrolimus,
Tacrolimus
- Immunomodulatory
effect
(Immunosuppressant).
42% - 50% Safe for short term or
intermittent long-term use.
4 Calcipotriene (Vit. D derivative)
/ Calcipotriene
- Calcipotriene
Monohydrate
- Affect the growth and
differentiation of
melanocytes and
keratinocytes.
Up to 50% (in combination
with corticosteroid) and with
low activity as monotherapy.
Safe
5 Pseudocatalase & Calcium /
Pseudocatalse + Calcium
- Pseudocatalase +
Calcium
- Breakdown the Hydrogn
peroxide (H2O2) which
accumulate in the upper
layer of skin (Anti-free
radical).
~ 45% Safe
11. KenaLeen® C re a m … Direction of use
For vitiligo batches away from joints (in face, neck, back …etc):
Patient has to apply KenaLeen Cream (at 7-10 AM, in this interval time the wave length of UVA will be
around 330 nm, the perfect one. Or (3-4 PM), also the wave length of UVA in this period will be the
same). After the patient applying the Cream he should keep it for (half an hour to 1 hour) in his affected
area then after that he has to wash it then expose directly to the sun light from (5-10 minutes), and patient
must use kenaleen cream once daily until the white patch changed to pink color then he can use it every
other day by the same procedure.
I
I For approved and rapid effect in vitiligo treatment, most of Drs use combination
therapy (especially with phototherapy).
For vitiligo batches which are on joints (like in knee or fingers …etc):Patient must follow
the directions above, which are for patches away from joints, but he should use it twice daily for 10
days, then once daily until the patches changed to pink color, after that every other day.
12. KenaLeen® Cream… Why it is a great brand?
1
2
3
4
5
6
Natural pathway for PUVA
therapy.
Effective immunomodulator
agent
Rich source of natural
powerful anti-oxidants.
Rich source of essential
minerals and vitamins for
vitiligo patients.
Cover all of the theories of
vitiligo topical treatment
Wide safety margin and
considered as cost effective
brand.
13. KenaLeen® Cream
R e f e r e n c e s
Psoralea corylifolia Linn.—“Kushtanashini” (Pharmacogn Rev. 2010 Jan-Jun; 4(7): 69–76.).
Immunomodulatory activity of biopolymeric fraction RLJ-NE-205 from Picrorhiza kurroa.(Int Immunopharmacol. 2006
Oct;6(10):1543-9. Epub 2006 Jun).
Preparative isolation and purification of psoralen and isopsoralen from Psoralea corylifolia by high-speed counter-current
chromatography (Journal of Chromatography A, 1057 (2004) 225–228).
Immunodulatory compounds from Picrorhiza kurroa: isolation and characterization of two anti-complementary polymeric
fractions from an aqueous root extract.( J Ethnopharmacol. 1989 Sep;26(2):169-82).
Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry).( Phytother Res. 2008 Jul;22(7):979-81.)
Antioxidant capacity and phenolic acids of virgin coconut oil.( Int J Food Sci Nutr. 2009;60 Suppl 2:114-23. Epub 2008 Dec
27.)
Psoralen and ultraviolet A and narrow-band ultraviolet B in inducing stability in vitiligo, assessed by vitiligo disease
activity score: an open prospective comparative study.( J Eur Acad Dermatol Venereol. 2007 Nov;21(10):1381-5.)
Guidelines for topical PUVA: a report of a workshop of the British Photodermatology Group (British Journal of Dermatology
2000; 142: 22±31.).