Granulation

G RANULATION I RAHUL SINGOUR Formulation & Development

Content ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Littelford loading mixer Diosna mixer/ granulator Littelford MGT mixer Gral mixer/ granulator FBD granulator

G ranulation: definition & concept ,[object Object],[object Object],[object Object]

O bjective & mechanism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

mechanism ,[object Object],[object Object],[object Object]

G ranules characteristic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

G ranules characteristic Dense and hard granules decreasing DT and dissolution rate Higher compression load Less friability ,[object Object],[object Object],[object Object],[object Object]

G ranules characteristic…….. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

G ranules characteristic…….. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

% C ompressibility ,[object Object],% Compressibility = (Tapped density – Bulk density/Tapped density)*100 % COMPRESSIBILITY FLOW DESCRIPTION 5 – 15 Excellent 12 – 16 Good 18 – 21 Fair 23 – 28 Poor 28 – 35 Poor 35 – 38 Very Poor > 40 Extremely Poor

F low Properties ,[object Object],[object Object],Hausner Ratio = Tapped Density / Bulk Density Φ = tan-1 (h / r) HAUSNER RATIO TYPE OF FLOW Less than 1.25 Good Flow 1.25 – 1.5 Moderate More than 1.5 Poor Flow ANGLE OF REPOSE TYPE OF FLOW < 25 Excellent 25 – 30 Good 30 – 40 Passable > 40 Very Poor

T echniques for granulation process ,[object Object],[object Object],[object Object],[object Object]

B asic processing step of granulation

D irect compression ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

C ompression granulation ,[object Object],[object Object],[object Object],[object Object],[object Object]

r oller compactor…. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

W et granulation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

W et granulation………. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

G ranulator for wet granulation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

L ittleford Loding mixer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Plow-shaped mixing tools Chopper blades Spray nozzles Horizontal cylindrical shell

[object Object],[object Object],[object Object],[object Object],D iosna mixer or granulator ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

mixer blade chopper blade ,[object Object],Uniform distribution of all formulation ingredients. Short mixing and granulation time. Useful working capacity of upto 80% to 40% of bowl volume. Uniform granules by gentle processing. Wide range of applications. Easy scale up & Scale down between machine sizes. Bowl shape design to have no dead spaces. D iosna mixer or granulator………..

L ittleford MGT mixer-granulator ,[object Object],[object Object],[object Object],[object Object],[object Object]

G ral mixer-granulator ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1 2 ,[object Object],[object Object]

G ral mixer-granulator……….

D ifference between Gral and Planetary mixer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

F luid Bed Granulation ,[object Object],[object Object],[object Object],[object Object]

F luid Bed Granulation Principle: Batch fluid bed granulation, Top Spray Principle: Batch fluid bed granulation, Bottom Spray ,[object Object],[object Object],Principle: continuous fluid bed granulation in the Glatt fluid bed (GF) Top Spray Principle: continuous fluid bed granulation in the Glatt fluid bed (GF) Bottom Spray

R eferences ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

G ranulation I I ,[object Object],[object Object],[object Object],[object Object],[object Object],To be continued…!!

Granulation

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