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Alpha domain structurs

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Nithin Chandran
Nithin Chandran

Made for 3rd year Protein Engineering class

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Alpha-Domain Structures
[object Object],[object Object],Single alpha helix does not have a hydrophobic core, it is marginally stable in solution Two (or 3,4, etc) helices can pack together and form a hydrophobic core
Coiled – coil (leucine zipper) ,[object Object],[object Object],[object Object]
The heptad repeat ,[object Object],[object Object],[object Object],[object Object],[object Object],1 8 15 22 a b c d e f g Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu
Why a heptad ? ,[object Object],[object Object],[object Object],[object Object]
Leu packs against Leu ,[object Object],[object Object],[object Object]
Interactions in coiled-coil ,[object Object]
Helix-helix Packing ,[object Object],[object Object],[object Object],[object Object]
Helix-helix Packing ,[object Object]
Knobs in Holes Model ,[object Object],[object Object]
“ Knobs in holes” model in coiled-coil ,[object Object],d a a d e
“ Ridges in grooves model” ,[object Object],[object Object],Ridge Ridge Groove
 
[object Object]
Two variants of “ridges in grooves” model ,[object Object],[object Object]
 
Four-helix Bundles ,[object Object],[object Object],[object Object]
Helices can be either parallel or anti parallel in four helix bundle ,[object Object]
Two leucine zippers can form a four helix bundle ,[object Object],[object Object],[object Object],Leu zipper
Dimeric RNA-binding Protein Rop ,[object Object],[object Object],[object Object],RNA RNA
Alpha-helical domains can be large and complex ,[object Object],[object Object]
Importin beta Involved in transporting (“importing”) proteins from cytosol to nucleus
Globin fold ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Globin Fold has been Preserved During Evolution ,[object Object],[object Object],[object Object]
Evolution of Globins ,[object Object],[object Object],[object Object],[object Object]
How do Proteins Adopt to Changes in the Size of Buried Residues? ,[object Object],[object Object],[object Object],[object Object]
Myoglobin A B C D E F H G N C
Hemoglobin ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hemoglobin
Sickle-cell anemia – a molecular disease ,[object Object]
Polymerization among hemoglobin molecules during sickle-cell anemia ,[object Object]
Mutant hemoglobin fibers in erythrocytes ,[object Object],Traffic jams can be caused in blood vessels by sickle shaped erythrocites
Why is Glu 6 mutation preserved rather than eliminated during evolution? ,[object Object],[object Object],[object Object]
 

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