This document discusses open notebook science, which aims to make the entire scientific process transparent by publishing preliminary data, failed experiments, and lab notebooks online in addition to traditional publications. It notes issues with the current closed system like difficulty finding solubility data and controversies that arose. Open notebook science could help address these problems by crowdsourcing data collection and allowing other researchers to build on and verify past work more easily. However, traditional peer review and metrics may need to evolve to fully recognize open notebook science contributions to scholarship.

1. Open Notebook Science Jean-Claude Bradley May 24, 2010 IGERT NSF meeting Associate Professor of Chemistry Drexel University

2. What is a Scientific Precedent? What is a Scientific Publication? What is Peer Review? What is Scholarship?

3. How bad is our current system? Try to find the solubility EGCG?

4. =2.3 g/L WTF?!

5. The NaH oxidation controversy

6. 15% NMR yield

7. Khalid Mirza and Marshall Moritz

9. Top results on a Google search

10. To Cite or Not to Cite?

12. “ I would never consider a claim made in a patent as blocking an author's claim of novelty.” Langmuir Editor What is a Scientific Precedent in Academia? What is a Scientific Precedent in Patent Law?

13. What is Scholarship?

14. What is Peer Review?

15. The Scandal of Bell’s Lab Notebook

16. Motivation: Faster Science, Better Science

17. TRUST PROOF

18. Crowdsourcing Solubility Data

19. ONS Challenge Judges

20. ONS Submeta Award Winners

21. Data provenance: From Wikipedia to…

22. … the lab notebook and raw data

23. Concentration (0.4, 0.2, 0.07 M) Solvent (methanol, ethanol, acetonitrile, THF) Excess of some reagents (1.2 eq.) How does Open Notebook Science fit with traditional publication?

24. Paper written on Wiki

25. References to papers, blog posts, lab notebook pages, raw data

26. Paper on Journal of Visualized Experiments (JoVE)

27. Pre-print on Nature Precedings

28. BUT… Open Access: the Choice that Keeps Giving.. and Giving…

29. Beware of your addiction to metrics: redundancy will reduce them

30. ONSArchive: Semi-Automated Snapshot of the Entire Scientific Record

31. Lulu.com Data Disks

34. Solubility Prediction (Andy Lang uses Abraham Model)

35. Reaction Attempts Book

36. Reaction Attempts Book: Reactants listed Alphabetically

37. For all Formats of ONS Projects

38. Conclusions The vehicles available to communicate science will continue to evolve. As long as proof is valued over trust there is no limit to what useful forms will emerge.