1. The document discusses open notebook science and making scientific data and assumptions openly accessible online through tools like wikis, blogs, and Google Docs. 2. It describes a collaboration between several researchers investigating drug targets for malaria and tumors through open sharing of docking procedures, results, raw data, and lab notebooks. 3. The collaboration optimized a reaction by systematically varying concentration, solvent, and reagents in experiments documented through an automated system and openly reported online.