AN INTRODUCTION

1. Process Analytical
Chemistry
Submitted To: Sir Inam Ul Haq
Submitted By: Muqaddas Abdul Sattar
Roll No: 3019
BS Chemistry 1st Semester
UNIVERSITY OF EDUCATION
1University of Education, Okara Campus

2. Table of Contents
 Introduction
 Motivation or Objectives
 Importance and Scope
 Comparison
 Findings
 Summary
 Conclusion
 References
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3. Introduction:
 Process Analytical Chemistry (PAC), is similar
to Process Analytical Technology (PAT) (for
example used for the pharmaceutical industry)
has its origins as a specialized form of analytical
chemistry used for process manufacturing.
Process analytical chemistry is the application of
analytical chemistry with specialized techniques,
algorithms, and sampling equipment for solving
problems related to chemical processes. The
chemical processes are for production and
quality control of manufactured products, and
process analytical technology is used to
determine the physical and chemical composition
of the desired products during a manufacturing
process. It is first mentioned in the chemical
literature in 1946
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4.  Process analysis initially involved sampling the variety
of process streams or webs and transporting samples
to quality control or central analytical service
laboratories. Time delays for analytical results due to
sample transport and analytical preparation steps
negated the value of many chemical analyses for
purposes other than product release. Over time it was
understood that real-time measurements provided
timely information about a process, which was far more
useful for high efficiency and quality. The development
of real-time process analysis has provided information
for process optimization during any manufacturing
process. The journal Analytical Chemistry
(journal) publishes a biennial review of the most recent
developments in the field
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5. Motivation Or Objective:
 The first real-time measurements in a
production environment were made with
modified laboratory instrumentation; in
recent times specialized process
and handheld instrumentation has been
developed for immediate analysis.
 Process Analytical Chemistry involves
the following sub-disciplines of analytical
chemistry:
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6. Importance:
 The terms “process analytical chemistry” and
 “on-line monitoring” are often used
synonymously. They are gaining increasing
attention
 and importance in both industry and
academia.
 The extent of agreement between the two
terms
 is indeed very broad in that they provide
sufficiently accurate and immediate
information on
 variables that describe the state of a
chemical reaction.
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7. Scope:
 Process Analytical Chemistry: Introduction
and Historical. Perspective ... Near-Infrared
Spectroscopy for Process Analytical
Chemistry: Theory, ...... A broadly accepted
definition of 'PA' is difficult to capture as
the scope of the methodology.
 Aims & Scope ... Global Analytical
Chemistry - An International Journal is
committed to publishing top-tier original
research in all areas of analytical
chemistry and related fields through a fair
and rigorous review process
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8. Comparison:
 International studentsStudents come
from over 125 different countries to
study at Imperial .... To introduce
chemometrics and process
analytical technology (PAT) as a ...
Fault detection: comparison of
analyser spikes with other analogue
signals. ... COD (chemical oxygen
demand) and VOC (volatile organic
compounds)
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9.  Analytical chemistry is the science
of obtaining, processing, and
... Analytical chemists are employed
in all aspects of chemical research in
industry, academia, ..... earns in your
area of the country, please refer to
the ACS Salary Comparator
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10. Graph:
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11. Findings:
 • PAC is the art and science of making
 measurements for the purpose of control
of
 large scale chemical processes.
 • In large companies, the number of “lab
 chemists” is decreasing and the number
of
 “process analyzers” is increasing.
 • Industry needs people with knowledge
of
 process analytical chemistry
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12. Suggestion:
 Your task is to construct an analytical
 laboratory in which
 – data is available > 98% of the time for 15
years;
 – each instrument gets one hour of
service/month;
 – updated analyses are available every 5
minutes;
 – the samples may be high pressure, high
 temperature, wet, and/or dirty;
 – the lab is in a corrosive environment.
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13. Summary:
 The aim of this report is to present recommendations for reporting
results
 concerning chemical process control and to deal with terms most
relevant to the viewpoints
 of both analytical chemists and process engineers. Part 1 gives a
brief description of the
 fundamentals involved in the basic analytical system. After
formulating and explaining the
 operating system, approaches to process control are classi®ed,
followed by the planning,
 design and sample manipulation of dynamic systems as well as
measurement and detection
 modules. The position of different components in the analytical
system and the relation to the
 operating system should be clearly indicated when presenting
results concerning process
 analytical chemistry.
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14. Reference:
 en.wikipedia.org/wiki/Process_analyti
cal_chemistry(31.01.15)
 onlinelibrary.wiley.com/book/10.../UA_
ProcessAnalyticalChemistry.pdf
 ubs.acs.org/doi/pdf/10.1021/ac030139
3
 pubs.acs.org/doi/pdf/10.1021/ac20097
4w
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