Slides from a CHEM 2P21 presentation March 22, 2016

1. +
Ian Gordon
CHEM 2P21
SciFinder Reaxys
SciFinder, Espacenet
eCPS ChemDraw
Exercise
Happy
Pearl Jacobson, Science Librarian,
Carleton University

2. The objective of this exercise is to:
• assist you with exploring the chemical literature
• know where, how and why to use the Reaxys, SciFinder, Espacenet,
eCPS, ChemSpider, etc. databases and ChemDraw software
• learn how to create citations using a citation management system
e.g. Zotero using ACS Style
• explore chemical naming conventions and reaction sequences, and,
• be better informed of small molecule drugs, antibiotics, their
chemical properties, reactions, regulatory and scholarly information.

10. Select one of the following antibiotics / antibacterial drugs list
below, a Drugs.com compound on the Medications for
Bacterial Infection list or pick a different drug / chemical of
your choice. Remember that you need to pick a drug that
allows you to complete all the elements of this assignment:
Amoxicillin, Ampicillin, Azithromycin, Cefaclor, Cefzil,
Cefoxitin, Cefprozil, Ceftin, Cefuroxime, Cephalexin,
Chloramphenicol, Ciprofloxacin, Clarithromycin,
Doxycycline, Erythromycin, Flagyl, Invanz, Merrem,
Nitrofurantoin, Free penicillin G, Rifampin, Streptomycin,
Tetracycline, Tigecycline, Trimethoprim, Tyrothricin, or
Zymar.

11. Why is this drug important/unique summarizing its bioactivity,
uniqueness, target indicator or mode of chemical action.
Which reaction is easiest to reproduce at Brock and why?
Is this paper’s reaction indicative of green chemistry and why?
Summarize, what is unique about this patent?
Using ChemDraw, create/copy a reaction sequence or a
single compound structure, insert name(s) and citation.
One thing you learned about Reaxys through this exercise!
Complete the following, where asked, in your own words, using one or two sentence:

16. +

24. Williams, J. M.; Brands, K. M. J.; Skerlj, R. T.; Jobson, R. B.; P. G.; et al.
Practical Synthesis of the New Carbapenem Antibiotic Ertapenem
Sodium. J. Org. Chem. 2005, 44, 7479–7487.

38. Junker, T.; Alexy, R.; Knacker, T.; Kümmerer, K.
Environ. Sci. Technol. 2006, 40, 318–324.

44. +
Ian Gordon
CHEM 2P21
SciFinder Reaxys
SciFinder, Espacenet
eCPS ChemDraw
Exercise
Happy
Pearl Jacobson, Science Librarian,
Carleton University