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CHEM 2P21 Winter 2019 Information Exercise

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Paul Zelisko Brock University March 27 2019 ppt slides

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CHEM 2P21 Winter 2019 Information Exercise

  1. 1. + Ian Gordon CHEM 2P21 Information Exercise March 27, 2019 Happy Pearl Jacobson, Science Librarian,
  2. 2. 1. Download and open ChemDraw 2. Search by chemical/drug by name and insert structure 3. Click on A text box and type in name 4. Centre and/or click on lasso or marquee box to drag text box and structure 5. Play about and learn the basics or watch any number of tutorial(s) 6. Copy/Scan and paste into Word
  3. 3. Xie, H.; Hao, H.; Xu, N.; Liang, X.; Gao, D.; Xu, Y.; Gao, Y.; Tao, H.; Wong, M. Pharmaceuticals and Personal Care Products in Water, Sediments, Aquatic Organisms, and Fish Feeds in the Pearl River Delta: Occurrence, Distribution, Potential Sources, and Health Risk Assessment. Sci. Total Environ. 2019, 659, 230–239. https://doi.org/10.1016/j.scitotenv.2018.12.222.
  4. 4. Napoleon, J. V. ; Manheri, M. K. Direct Transformation of Baylis- Hillman Acetates into N-Substituted Quinolones through an… Oxidation Sequence. Synthesis 2011, 20, 3379-3388.
  5. 5. Napoleon, J. V.; Manheri, M. K. Direct Transformation of Baylis-Hillman Acetates into N-Substituted Quinolones through an SN2′ → SNAr → (Δ3,4-Δ2,3 Shift) → Oxidation Sequence. Synthesis 2011, 20, 3379-3388.
  6. 6. Yachao, L. Chemical Synthesis Method for Norfloxacin. Patent Application CN 107445892, 2017.
  7. 7. Possibly new: • searching Reaxys chemistry and Espacenet patent databases • knowledge of SciFinder (MEDLINE / PubMed) and Reaxys (Ovid / Embase) indexing conventions • using small molecule databases including PubChem, ChemSpider Drugs.com • accessing commercial chemical manufacturing suppliers e.g. Sigma-Aldrich • determining whether to make or purchase chemical compounds • register, download and use ChemDraw chemical drawing software • being better informed of biochemical research on antibiotics / antibacterial drug development, their chemical properties, reactions, regulatory and scholarly information • analyzing and commenting on concepts fundamental to global health and green chemistry
  8. 8. + Ian Gordon CHEM 2P21 Information Exercise March 28, 2018 Happy Pearl Jacobson, Science Librarian,

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