PHYTOASSAY<br />Plant-based technology for toxicity screening in drug discovery <br />3R Laboratories, LLC. All Rights Res...
2<br />3R LABORATORIES’ MISSION STATEMENT<br />Our mission is to improve drug safety and reduce animal experiments by usin...
3<br />THE PROBLEM<br />There is a high demand for reliable toxicity screening in pharmaceutical industry<br />The cost of...
4<br />THE PROBLEM<br />Animal experiments – costly, lengthy, and unethical<br />Cell culture-based methods – failed to me...
5<br />STRATEGIC OPPORTUNITY<br />Plant Respiration Test<br />Highly Reproducible and Sensitive<br />The only test that ca...
6<br />STRATEGIC OPPORTUNITY<br />Plant Respiration Test<br />	Preliminary results show better correlation with animal mod...
7<br />MARKET SIZE<br />US market for toxicology in vitro, 2007 (early phase drug discovery only)<br />	$1.1 billion, AAGR...
8<br />QUESTIONS?<br />information@3RLaboratories.com<br />
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Phyto Assay Presentation Pitchfest

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Phyto Assay Presentation Pitchfest

  1. 1. PHYTOASSAY<br />Plant-based technology for toxicity screening in drug discovery <br />3R Laboratories, LLC. All Rights Reserved.<br />
  2. 2. 2<br />3R LABORATORIES’ MISSION STATEMENT<br />Our mission is to improve drug safety and reduce animal experiments by using plant models in predictive toxicology.<br />The company is named after The Principle of 3Rs:<br />Reduce, Refine and Replace animal experiments with suitable alternatives.<br />(Russell and Burch, 1959)<br />
  3. 3. 3<br />THE PROBLEM<br />There is a high demand for reliable toxicity screening in pharmaceutical industry<br />The cost of developing a successful drug is $1.4 billion; 72% of this cost is wasted on failures. Improving the prediction of failures before clinical trials by only 10% could save $100 million in development costs per drug <br />Safety-related drug withdrawals: <br />Merck lost 11% of its revenue ($2.5B) when it pulled Vioxx off the market in 2003; additionally, Merck funded $4.5B in settlement payouts<br />Pfizer&apos;s Celebrex sales dropped 48% ($1.5B) in 2004 due to safety concerns <br />
  4. 4. 4<br />THE PROBLEM<br />Animal experiments – costly, lengthy, and unethical<br />Cell culture-based methods – failed to meet the industry expectations, poor reproducibility<br />&quot;Previously, in vivo evaluations of toxicity were used sparingly in discovery. Now, we perform early in vivo studies on every compound being advanced into development, because catching liabilities earlier is extremely important. &quot; Bruce Car, PhD, Bristol-Myers Squibb<br />
  5. 5. 5<br />STRATEGIC OPPORTUNITY<br />Plant Respiration Test<br />Highly Reproducible and Sensitive<br />The only test that can rank compounds according to toxicity<br /> &quot;The definitive answer is really at the end of the clinical trials. What we want to do early on is to proceed to a rank-ordering exercise and select the candidates with an optimal toxicology profile to move into a preclinical safety study.&quot; Eric Blomme, PhD, Abbott Laboratories <br />Ethical<br /> The US Animal Welfare Act requires manufacturers and researches to explore all possible alternatives before resorting to animal testing.<br />
  6. 6. 6<br />STRATEGIC OPPORTUNITY<br />Plant Respiration Test<br /> Preliminary results show better correlation with animal models than cell cultures<br />Regardless of the mechanism of action, toxic substances affect cellular structures of an organism and disrupt normal cellular processes <br />Cellular respiration is used as a measure of the disruption in cellular metabolism<br />
  7. 7. 7<br />MARKET SIZE<br />US market for toxicology in vitro, 2007 (early phase drug discovery only)<br /> $1.1 billion, AAGR 15%<br />
  8. 8. 8<br />QUESTIONS?<br />information@3RLaboratories.com<br />

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