This symposium discusses strategies for developing teachers' TPACK (Technological Pedagogical Content Knowledge) through professional development programs. Four contributions will be presented that use design-based approaches to prepare pre-service teachers in various countries to integrate technology. The first discusses a program in Kuwait using design teams, the second a US master's program, the third design teams for math teachers in Ghana, and the fourth the development of a TPACK assessment instrument. The goal is to identify characteristics of effective professional development for technology integration.