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A Framework for Bioinformatics on the Microsoft PlatformSimon MercerDirector, Health & WellbeingMicrosoft Research Connections 2/25/2011
Vision and Community To support the genomics workflow from DNA sequencer output to contiguous, fully-annotated genome Community consists of ‘scientific programmers’: ,[object Object]
May be wet-bench scientists themselves
Frequently support the lab and analyze the data
Commercial scientific programmers often located in dedicated service units, more CS background,[object Object]
open source under the Apache 2.0 license
foundation upon which other tools can be builtProvides various components useful for biological analysis ,[object Object]
support for DNA, RNA and protein sequences
algorithm framework for analysis and transformation

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Bosc mercer

  • 1. A Framework for Bioinformatics on the Microsoft PlatformSimon MercerDirector, Health & WellbeingMicrosoft Research Connections 2/25/2011
  • 2.
  • 3. May be wet-bench scientists themselves
  • 4. Frequently support the lab and analyze the data
  • 5.
  • 6. open source under the Apache 2.0 license
  • 7.
  • 8. support for DNA, RNA and protein sequences
  • 9. algorithm framework for analysis and transformation
  • 10.
  • 11. it provides the basis for visualizations to be built on top ofYour Application MBF .NET Framework 4.0
  • 12. Cross-Platform Capabilities Possible to target non-Windows platforms using Silverlight / Mono / Moonlight
  • 13. New in v2 Advanced Math functions Available free to academics via the Intel MKL library and Sho Comparative DNA sequence assembly Assemble to reference of a related strain or species Command line tools Exposing MBF features on the command line Discovery via Visualization Natural navigation and annotation of assembled genomes Delight the Developer Ability to easily and efficiently create, extend and debug applications Grow the Community Provide training, easy on-ramps and incentives for contributing to the library
  • 14. Open Source Development Source Code Community Support MBF.codeplex.com
  • 15.
  • 16. Installers and tools available from:http://research.microsoft.com/bio/
  • 17. Source Code and developer community support available from:http://mbf.codeplex.comThe name is going to change The MBF project is NOT guided by Microsoft alone The MBF project will NOT be owned by Microsoft:

Editor's Notes

  1. Extensibilitycore concepts mapped as interfacescan easily provide alternative implementations or add any missing features you needLanguage Neutralitybuilt on top of .NET – use any supported languagesupports dynamic languages such as IronPythonDesigned and implemented using best practicescommented source code provided so nothing is a black box algorithms all cite publications
  2. To use MBF in other environments, you will use Silverlight as your application style and then rely on Mono/Moonlight or the Silverlight plug-in on the OSX platform to run your code. You can still use Visual Studio for your IDE on the Windows platform, or if you are willing to work with the source code, you can use a Mono-based IDE such as MonoDevelop or SharpDevelop. MBF v2 will also support a Silverlight version with a subset of functionality but capable of running wherever Silverlight is supported