0
+

Done by: Ahmad Mhd Al-dhlawiy
Hamad Emad Dhuhayr
+

Contents …

General concepts for hepatitis.
 Types of hepatitis.
 HBV Structure & Antigens.
 Transmission Epidemiolo...
+

General Concepts …


VIRAL HEPATITIS :- is a serious disease caused by virus that
attacks the liver . There are variou...
+

Terms for Hepatitis ….


Acute: Short term and/or severe.



Chronic: Lingering or lasting - may or may not be severe...
+

Viral hepatitis …
+

Viral hepatitis …
+

HBV Structure & Antigens …

HBsAg = surface (coat) protein ( 4 phenotypes : adw, adr, ayw and ayr)
HBcAg = inner core p...
+

Replication …
+

Modes of Transmission for HBV


Parenteral - IV drug abusers, health workers are
at increased risk.



Sexual - sex w...
+
+
+

Incidence of Hepatitis in KSA
+
High-risk groups for HBV infection
 People from endemic regions
 Babies of mothers with chronic HBV
 Intravenous drug...
+

Concentration of Hepatitis B Virus
in Various Body Fluids …

High
blood
serum
wound exudates

Moderate
semen
vaginal fl...
+

Pathogenesis & Immunity …


Virus enters hepatocytes via blood



Immune response (cytotoxic T cell) to viral antigen...
+

Clinical pictures …
+

Possible Outcomes of HBV Infection
Acute hepatitis B infection

3-5% of adultacquired infections

95% of infantacquired...
+

Acute Hepatitis B Infection
+

Laboratory Diagnosis …
+

Treatment …
Interferon

alfa (Intron A)
is 30 to 40%.

Lamivudine

Response rate

(Epivir HBV)

(relapse ,drug resist...
+

Prevention …
 Vaccination

- highly effective recombinant vaccines.
 Hepatitis B Immunoglobulin (HBIG)
-exposed withi...
+

Hepatitis B Vaccine
 Infants:

several options that depend on status of the

mother
 If mother HBsAg negative: birth,...
+

References

website


http://www.hepatitis-central.com/hbv/hepbfaq/viroligy.html



http://en.wikipedia.org/wiki/Hepa...
+



AHMED AL DAHLAWY



HAMAD EMAD THUHAYR
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Hepatitis B

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Transcript of "Hepatitis B "

  1. 1. + Done by: Ahmad Mhd Al-dhlawiy Hamad Emad Dhuhayr
  2. 2. + Contents … General concepts for hepatitis.  Types of hepatitis.  HBV Structure & Antigens.  Transmission Epidemiology.  Pathogenesis & Immunity.  Clinical pictures.  Laboratory Diagnosis.  Treatment Prevention.  References. 
  3. 3. + General Concepts …  VIRAL HEPATITIS :- is a serious disease caused by virus that attacks the liver . There are various strains of viral hepatitis which can cause lifelong infection, cirrhosis ( scarring) of the liver , liver cancer , liver failure, and death.  six medically important viruses are commonly described as “hepatitis viruses”: HAV,HBV,HCV,HDV,HEV,HGV
  4. 4. + Terms for Hepatitis ….  Acute: Short term and/or severe.  Chronic: Lingering or lasting - may or may not be severe  Fulminant: Developing quickly and lasting a short time, high mortality rate.  Cirrhosis: Hardening: may be the result of infection or toxins (e.g. alcohol)  Jaundice: Yellowing of the skin, eyes, etc due to raised levels of bilirubin in the blood due to liver damage.  Hepatocellular carcinoma: is closely associated with hepatitis B, and at least in some regions of the world with hepatitis C virus.
  5. 5. + Viral hepatitis …
  6. 6. + Viral hepatitis …
  7. 7. + HBV Structure & Antigens … HBsAg = surface (coat) protein ( 4 phenotypes : adw, adr, ayw and ayr) HBcAg = inner core protein (a single serotype) HBeAg = secreted protein; function unknown
  8. 8. + Replication …
  9. 9. + Modes of Transmission for HBV  Parenteral - IV drug abusers, health workers are at increased risk.  Sexual - sex workers and homosexuals are particular at risk.  Perinatal →infant. - (Vertical) - mother(HBeAg+)
  10. 10. +
  11. 11. +
  12. 12. + Incidence of Hepatitis in KSA
  13. 13. + High-risk groups for HBV infection  People from endemic regions  Babies of mothers with chronic HBV  Intravenous drug abusers  People with multiple sex partners  Hemophiliacs and other patients requiting blood and blood product treatments  Health care personnel who have contact with blood
  14. 14. + Concentration of Hepatitis B Virus in Various Body Fluids … High blood serum wound exudates Moderate semen vaginal fluid saliva Low/Not Detectable urine feces sweat tears breastmilk
  15. 15. + Pathogenesis & Immunity …  Virus enters hepatocytes via blood  Immune response (cytotoxic T cell) to viral antigens expressed on hepatocyte cell surface responsible for clinical syndrome  5 % become chronic carriers (HBsAg> 6 months)  Higher rate of hepatocellular ca in chronic carriers, especially those who are “e” antigen positive  Hepatitis B surface antibody likely confers lifelong immunity (IgG anti-HBs)  Hepatitis B e Ab indicates low transmissibility
  16. 16. + Clinical pictures …
  17. 17. + Possible Outcomes of HBV Infection Acute hepatitis B infection 3-5% of adultacquired infections 95% of infantacquired infections Chronic HBV infection Chronic hepatitis 12-25% in 5 years 6-15% in 5 years Cirrhosis Hepatocellular carcinoma Death 20-23% in 5 years Liver failure Liver transplant Death
  18. 18. + Acute Hepatitis B Infection
  19. 19. + Laboratory Diagnosis …
  20. 20. + Treatment … Interferon alfa (Intron A) is 30 to 40%. Lamivudine Response rate (Epivir HBV) (relapse ,drug resistance) Adefovir dipivoxil (Hepsera)
  21. 21. + Prevention …  Vaccination - highly effective recombinant vaccines.  Hepatitis B Immunoglobulin (HBIG) -exposed within 48 hours of the incident/ neonates whose mothers are HBsAg and HBeAg positive.  Other measures -screening of blood donors, blood and body fluid precautions.
  22. 22. + Hepatitis B Vaccine  Infants: several options that depend on status of the mother  If mother HBsAg negative: birth, 0-2m,4-6m  If mother HBsAg positive: vaccine and Hep B immune globulin within 12 hours of birth, 1-2m, <6m  Adults  * 0,1, 6 months Routine booster doses are NOT routinely recommended for any group  Vaccine recommended in  All those aged 0-18  Those at high risk
  23. 23. + References website  http://www.hepatitis-central.com/hbv/hepbfaq/viroligy.html  http://en.wikipedia.org/wiki/Hepatitis_B  http://www.who.int/mediacentre/factsheets/fs204/en/index.html  http://www.cdc.gov/vaccines/pubs/vis/downloads/vis-hep-b.pdf  http://www.worldhepatitisalliance.org/AboutViralHepatitis/Prevention_Diagnosis_Treatment.aspx  http://emedicine.medscape.com/article/177632-overview Text books  Richard A, HARVEY, Pamela C,Champe, Bruce D, Fisher. Microbiology 2nd edition. Lippicott Williams & wilkins. Chapter 26. PP(273-282)  Raphael Rubin, David S. Strayer. Rubin’s pathology 5th edition. Lippicott Williams & wilkins. Chapter 14. PP(637-640)
  24. 24. +  AHMED AL DAHLAWY  HAMAD EMAD THUHAYR
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