A systematic approach is outlined for cytopathology diagnosis. First, gather all available patient data. Second, determine if the sample is adequate and if the microscopic elements are compatible with expected findings based on the lesion's location. Finally, characterize the sample considering morphology and any additional assays, commenting on whether it is neoplastic, benign, malignant primary or secondary, or a non-neoplastic abnormality.

1. YES
NOYES
CORRECT
Fix Error
A
Do we already know available information?
YES
YES
YES NO
NO
NO
Gather all patient data
C
B
Are the microscopic elements compatible
with the expected histopathological findings
according to topography of the lesion?
Ectopic tissue
Mistake
Do we have an adequate sample?
Is it a neoplasm?
NO
Is it benign, suspicious or malignant?
If malignant: Is it a primary malignancy or a
secondary one?
Is it completely negative? OR
Is it a non-neoplastic abnormal condition?
Consider morphology and -if needed- any of the tools like ICC,
cytometry, molecular assays
comment @ E
D
Figure 1. A Systematic Approach to Cytopathology Diagnosis.
C D E
D
EE