Calcitonin 01

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Yusuke Saito

calcitonin

Health & Medicine

Diffusible Non-diffusible
Ca2+ concentration in ECF
(bood and interstitium)
• Free Ca2+ (50%)
• Action
potentials
• Contraction
muscles
• Hormon
secretion
• Blood
coagulation
• Ca2+ linked with
oxalate/phospate
• Electricallyneutral
• Not useful for
celluarprocesses
• Ca2+ bound
protein (40%)
• Albumin
• Large
• Charged
• Unenvolved in
cellular
processes

• Low • High
Ca2+ level
PTH Vitamin Dcalcitonin
2.25 - 2.75 mmol/L
phosphateconcentrationin plasma
0.8 - 1.6 mmol/L

Calcitonin hormone
• Decreases
• plasma concentrationof calcium
• has functions opposing those of PTH

Calcitonin hormone
• Inhibits
• bone resorption
• suppressing directly the
activity of osteoclasts
• osteoclastsformation
• Supports
• the accumulationof calcium in
bones

Calcitonin secretion
• Is stimulated by
• increase of the extracellular
calcium levels
• simple negative feedback
regulation

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Calcitonin 01

1. Diffusible Non-diffusible Ca2+ concentration in ECF (bood and interstitium) • Free Ca2+ (50%) • Action potentials • Contraction muscles • Hormon secretion • Blood coagulation • Ca2+ linked with oxalate/phospate • Electricallyneutral • Not useful for celluarprocesses • Ca2+ bound protein (40%) • Albumin • Large • Charged • Unenvolved in cellular processes

3. • Low • High Ca2+ level PTH Vitamin Dcalcitonin 2.25 - 2.75 mmol/L phosphateconcentrationin plasma 0.8 - 1.6 mmol/L

4. Thyroid gland and calcitonin

7. Calcitonin hormone • Decreases • plasma concentrationof calcium • has functions opposing those of PTH

8. Calcitonin hormone • Inhibits • bone resorption • suppressing directly the activity of osteoclasts • osteoclastsformation • Supports • the accumulationof calcium in bones

9. Calcitonin secretion • Is stimulated by • increase of the extracellular calcium levels • simple negative feedback regulation

Calcitonin 01

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