In the human population, a deleterious recessive allele responsible for a lethal genetic disease occurs at a frequency of 0.05. What should be the per-generation rate of mutation from the normal allele to the deleterious allele if the persistence of the deleterious allele is to be explained by mutation-selection balance? Solution deleterious recessive allele genetic frequency=0.05 per generaton frequency here=1-0.05=0.85 The pergeneration rate=0.85/0.05=17.0.

1. In the human population, a deleterious recessive allele responsible for a lethal genetic disease
occurs at a frequency of 0.05. What should be the per-generation rate of mutation from the
normal allele to the deleterious allele if the persistence of the deleterious allele is to be explained
by mutation-selection balance?
Solution
deleterious recessive allele genetic frequency=0.05
per generaton frequency here=1-0.05=0.85
The pergeneration rate=0.85/0.05=17.0