HISTo slides of Adenocarcinoma and lymph node metastasis

1. HISTOPATHOLOGY SLIDES
OF
ADENOCARCINOMA OF
COLON
LYMPH NODE METASTASIS
DR SANDEEP SINGH GMC

2. ADENOCARCINOMA OF COLON
 Colorectal carcinoma the most
common form of visceral cancer.
Common rectum.
 G/A The tumour has distinctive
features in right and left- sided colonic
cancer. The right-sided growth, tends
to be fungating, large, cauliflower-like,
soft and friable mass projecting into
the lumen .The left-sided growth, on
the other hand, has napkin-ring
configuration. encircles the bowel wall

3. Right-sided colonic carcinoma.The colonic wall shows thickening with presence of a
luminal growth (arrow). The growth is cauliflower-like, soft and friable projecting into the
lumen. B, Left-sided colonic carcinoma. Sectioned surface shows napkin ring narrowing
of the lumen while the colonic wall shows circumferential firm thickening (arrow).

4. M/E
 The microscopic appearance on right-
sided and left- sided colonic cancer is
similar:
 The tumour has infiltrating glandular
pattern in the colonic wall with varying
grades of differentiation of tumour
cells.
 About 10% cases show mucin-
secreting colloid carcinoma with pools

5. Colonic adenocarcinoma
. A, Moderately differentiated. B, Mucin-secreting adenocarcinoma.

7. LYMPH NODE METASTASIS
 The regional lymph nodes may show
metastatic deposits,
 most commonly from carcinomas but
sometimes sarcomas may also
 metastasise to the regional lymph
nodes.

8. G/A
 The affected lymph nodes are
enlarged and matted.
 Cut surface shows homogeneous,
grey-white deposits with areas of
necrosis

9. Metastatic carcinoma in lymph nodes. Matted mass of lymph nodes is
surrounded by fat. Cut surface shows large irregular areas of grey-white
colour replacing grey-brown nodal tissue.

10. M/E
 The features of metastatic carcinoma
reproduce the picture of primary tumour.
the features are :
 Initially, the tumour is seen in the
subcapsular sinus but advanced cases
show replacement of the nodal
architecture by masses of malignant
cells.
 The tumour is seen as solid nests, cords
and poorly- formed glandular structures.
 The tumour cells show varying degree of
anaplasia and mitotic activity.
 Part of cortex and capsule of the lymph
node are intact

11. Metastatic carcinoma in lymph node. Lymphatic spread beginning by lodgement of tumour cells in subcapsular sinus via afferent lymphatics entering at the convex surface of
Metastatic carcinoma in lymph node. Lymphatic spread beginning
by lodgement of tumour cells in subcapsular sinus via
afferent lymphatics entering at the convex surface of