Donecept Tablets (Generic Donepezil Hydrochloride Tablets)

Donecept Tablets (Generic Donepezil Hydrochloride Tablets)
© The Swiss Pharmacy

Donecept Tablets (Generic Donepezil Hydrochloride
Tablets) belong to a group of medicines called
acetylcholinesterase inhibitors and are used to treat
the symptoms of dementia in patients diagnosed as
having mild to moderately severe Alzheimer’s disease.
They are also are indicated for the treatment of vascular
dementia.

Donecept Tablets
(Generic Donepezil
Hydrochloride
Tablets) are
manufactured by
Cipla Limited, India in
the strengths of 5 mg
and 10 mg.

Chemical Structure

The active ingredient
contained in Donecept
tablets is Donepezil
Hydrochloride.
Each film-coated
Donecept tablet
contains 5 mg or 10 mg
of Donepezil
Hydrochloride
equivalent to 4.56 mg or
9.12 mg Donepezil free
base, respectively.

Uses of Donecept 5 mg and 10 mg Tablets:
Donecept (Generic Donepezil Hydrochloride Tablets) is a prescription medicine
to treat dementia (memory loss and mental changes) associated with mild,
moderate and severe Alzheimer’s disease. Donepezil Hydrochloride tablets
can help with mental function and with doing daily tasks. Donepezil
Hydrochloride tablets do not work the same in all people. Some patients may
seem much better, get better in small ways or stay the same, get worse over
time but slower than expected, not change and then get worse as expected.
Donepezil will not not cure Alzheimer's disease, but it may improve memory,
awareness, and the ability to function. This medication is an enzyme blocker that
works by restoring the balance of natural substances (neurotransmitters) in the
brain.
Donepezil Hydrochloride tablets do not cure Alzheimer’s disease. All
patients with Alzheimer’s disease get worse over time, even if they take
Donepezil Hydrochloride tablets.
URL: https://www.theswisspharmacy.com/product_info.php?info=p9519_Donepezil-HCl-Tablets.html

Recommended Adult Dosage
The dose of Donecept Tablets (Generic Donepezil Hydrochloride
Tablets) is given below:
Mild to Moderate Alzheimer’s Disease:
5 mg or 10 mg administered once daily
Treatment should be initiated with Donecept Tablets 5 mg/day (once-
a-day dosing). Donecept Tablets should be taken orally just before
bedtime. Donecept Tablets can be taken with or without food. The
dose of 5 mg/day should be maintained for at least 1 month in order to
allow the earliest clinical responses to treatment to be assessed and to
allow steady-state concentrations of Donepezil Hydrochloride to be
achieved.

Recommended Adult Dosage
A dose of 10 mg once daily can be administered once patients
have been on a daily dose of 5 mg for 4 to 6 weeks.
Donepezil Hydrochloride tablets have not been approved
as a treatment for any medical condition in children.

Contraindications
➔
Donecept tablets are contraindicated in patients with a known
hypersensitivity to Donepezil Hydrochloride, piperidine
derivatives or any component of the tablet.

Storage Instructions
Donecept Tablets (Generic Donepezil Hydrochloride Tablets) have to
be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to
77°F) with excursions permitted between 15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away from children and pets.

Warnings
Cholinesterase inhibitors are likely to exaggerate succinylcholine
type
muscle relaxation during anesthesia.
Cholinesterase inhibitors may have vagotonic effects on the sinoatrial
and atrioventricular nodes manifesting as bradycardia or heart block.
Donecept can cause vomiting. Patients should be observed closely at
initiation of treatment and after dose increases.
Patients should be monitored closely for symptoms of active or occult
gastrointestinal (GI) bleeding, especially those at increased risk for
developing ulcers.

Warnings
The use of Donecept tablets in a dose of 23 mg once daily is
associated with weight loss.
Although not observed in clinical trials of Donepezil
Hydrochloride tablets, Cholinomimetics may cause bladder
outflow obstructions
Cholinomimetics are believed to have some potential to cause
generalized convulsions.
Cholinesterase inhibitors should be prescribed with care to
patients with a history of asthma or obstructive pulmonary
disease.

Possible Side Effects
Most common side effects observed during clinical studies of
Donepezil Hydrochloride tablets were nausea, diarrhea, insomnia,
vomiting, muscle cramps, fatigue, and anorexia.
Call the doctor immediately in case the patient has the following
Donecept side effects: fainting, heartburn or stomach pain that is new
or won’t go away, nausea or vomiting, blood in the vomit, dark
vomit that looks like coffee grounds, bowel movements or stools that
look like black tar, new or worse asthma or breathing problems,
seizures or difficulty passing urine.

Possible Side Effects
The most side effects, defined as those occurring at a frequency of at least 5% in
patients receiving 10 mg/day and twice the placebo rate, are largely predicted by
the cholinomimetic effects of Donepezil.
These include nausea, diarrhea, insomnia, vomiting, muscle cramp, fatigue and
anorexia.
These side effects were often transient, resolving during continued Donepezil
treatment without the need for dose modification.

Donecept Tablets Overdosage
Overdosage with cholinesterase inhibitors can result in cholinergic
crisis characterized by severe nausea, vomiting, salivation, sweating,
bradycardia, hypotension, respiratory depression, collapse and
convulsions. Increasing muscle weakness is a possibility and may
result in death if respiratory muscles are involved.

Treatment of Donecept Tablets Overdosage
Tertiary anticholinergics such as Atropine may be used as an antidote
for Donepezil Hydrochloride (Donecept Tablets) overdosage.
Intravenous Atropine Sulfate titrated to effect is recommended: an
initial dose of 1.0 to 2.0 mg IV with subsequent doses based upon
clinical response.
Atypical responses in blood pressure and heart rate have been
reported with other cholinomimetics when co-administered with
quaternary anticholinergics such as glycopyrrolate.
It is not known whether Donepezil Hydrochloride (Donecept Tablets)
and/or its metabolites can be removed by dialysis.

Donecept Tablets During Pregnancy
Donepezil Hydrochloride (Donecept Tablets) has been classified by the
US FDA as Pregnancy Category C.
There are no adequate or well-controlled studies in pregnant
women. Donecept (Donepezil Hydrochloride Tablets) should be
administered during pregnancy only if the potential benefit justifies the
potential risk to the fetus.
Oral administration of Donepezil to pregnant rats and rabbits during the
period of organogenesis did not produce any teratogenic effects at
doses up to 16 mg/kg/day (approximately 6 times the maximum
recommended human dose [MRHD] of 23 mg/day on a mg/m2 basis)
and 10 mg/kg/day (approximately 7 times the MRHD on a mg/m2
basis), respectively.

Donecept Tablets (Generic Donepezil
Hydrochloride Tablets) are manufactured by Cipla
Limited, India.

Donecept Tablets (Generic Donepezil Hydrochloride Tablets)

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