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1 of 44
Ms. Sweta bijukshe lecturer
,BMI
1
INTRODUCTION
It is derived from the Latin
word gutta, meaning "a drop"
(of liquid).
Earlier it was believed that an
acute attack of the disease
was the result of poison
dropping into a joint
Disease of the ‘KINGS’ (Rich foods have a
higher concentration of protein. This could
cause major problems for a person
afflicted with gout)
2
GOUT
“The disease of kings" or “Rich man's disease".
The King of Pain
• Benjamin Franklin
• Thomas Jefferson
• Sir Isaac Newton
• Charles Darwin
4
 According to Brunner & Suddarth’s Text
book of Medical –Surgical Nursing, gout is
“A heterogeneous group of conditions related to a
genetic defect of purine metabolism resulting in
hyperuricemia. Over secretion of uric acid or a
renal defect resulting in decreased excretion of
uric acid, or a combination of both,
occurs”(2010).
 Characterized by hyperuricaemia ,acute
arthritis, chronic to tophaceous arthritis
& gouty nephropathy.
DEFINITION
5
6
7
8
INCIDENCE
• Prevalence is reported to be about 2%.
• Gout occurs more frequently in men than
women over 40yrs M:F= (9:1)
• The peak age of attack is 75 to 80 yrs
• The incidence of gout become approximately
equal b/t the sexes after 60yrs.
9
ETIOLOGY
Classification causes of
Gout
Primary Gout
Secondary Gout
10
11
12
Contd…
Or causes may be discusses as :
• Endogenous cause
• Exogenous cause
13
Endogenous
cause
Body build (associated
with obesity)
Cell breakdown (multiple
myeloma, leukemia's,
lymphomas, psoriasis
Family History
Reduced renal
function
14
Exogenous
Dietary purines (liver,
red meat, beans, peas,
lentils)
Alcohol
Drugs (thiazides &
loop diuretics, low
dose salicylates
Occupational lead
exposure
15
16
PATHOPHYSIOLOGY
 Synovial fluid is a poor solvent for monosodium urate
than plasma, urates in the joint fluid become
supersaturated more easily ,particularly in the peripheral
joints(ankles, toes) which have low temperature. With
prolonged hyperuricemia,crystal & microtophi of urates
develop in the synovial & in the joint cartilage.
 Crystal are released to synovial fluid & they are chemo-
attractant for neutrophils & macrophages which is the
hallmark of acute attack.
 Repeated attacks of acute arthritis lead eventually to
chronic arthritis & formation of tophi in the inflamed
synovial membranes & periarticular tissue ,as well as
elsewhere.
 In time, sever damage to the cartilage develops & the
function of the joints is compromised.
17
increased purine
synthesis, decreased
renal excretion
A high dietary intake
of purine, alcohol
intake
Increase uric acid in
the blood
(hyperuricemia)
Deposition of uric
acid into the joints
GOUT
18
19
20
21
Acute gouty arthritis
 Severe pain, tenderness, warmth, redness
and swelling .
 Acute Gout attacks- needle-like pains on
use of the joint affected.
 First joint of the toes
(metatarsophalangeal), 90% patients
experience acute attacks in the great toe
23
Cont…
• Insteps - ankles, heels, knees, wrists, fingers,
and elbows.
• Commonly the first attacks - at night.
• Systemic signs - leukocytosis, fever, and
increase ESR
• Early attacks tend to subside spontaneously
over 3 to 10 days.
INTERVAL GOUT
• Complete remission of symptoms,
• most patients experience a second attack from
six months to two years later.
• If they are untreated, the attacks will increase
in frequency
CHRONIC GOUT
• Stage of Gout - reached after many years. Hard
or gritty (tophaceous) deposits - joint and
tendons.
• Chronic joint symptoms - permanent erosive
joint deformity appears.
• Limitation of motion, often involving multiple
joints of the hands, feet, or both.
CHRONIC GOUT
• Visible "tophi," deposits of monosodium urate
-cartilage, synovial membranes, tendons, and
soft tissues, after an average of about 12 years.
• Tophi visible - margin of the ear lobe (pinna),
fingers, hands, knees, and feet, and also the
ulnar surface of the forearm.
• Signs of renal involvement
Diagnostic Test
Medical History and
Physical Examination
Test to measure levels
of uric acid in blood
30
Diagnostic Test con’t
Test to measure levels
of uric acid in urine
Extremity X-ray
31
Diagnostic Test con’t
Joint fluid analysis
32
Medical treatment
33
For acute gout
ii.Colchicine: Lower the deposition of
uric acid & interferes with leukocyte
infiltration, thus reducing inflammation
34
i.NSAIDs: Indomethacine, Naproxen,
Phenyl butazone
iii. Corticosteroid :may be used in pt. who have no response to other
therapy
For chronic gout
Probenecid: uricosuric agent;
inhibits renal reabsorption of
urates & increases the urinary
excretion of uric acid
Sulfinpyrazone: uric acid
synthesis inhibitor
35
Allopurinol: uric acid
synthesis inhibitor
Surgical Treatment
• If gout symptom have occurred off and on without treatment,
uric acid crystals may have built up in the joints to form gritty,
chalky nodules called tophi.
36
Surgical Treatment con’t
This tophi can cause infection pain, pressure, and
deformed joints.
Surgery will recommend by doing the excision to remove
the tophi
37
Complication
Recurrent gout Advanced gout
Kidney damage
Joint damage
Tophi
Kidney stone
38
NURSING CARE PLAN
Nursing Diagnosis: Acute pain related to swelling joints
Nursing Intervention:
•The pain should be assessed on an ongoing basis
using a scale of one to 10 to describe the severity.
•Use cognitive therapy such as creative visualization
to distract the patient from his pain.
•Apply cold packs to inflamed joints to ease
discomfort and reduce swelling.
•Encourage the patient to perform techniques that
promote rest and relaxation.
39
NURSING CARE PLAN con’t
Nursing Diagnosis: Activity Intolerance related to pain
Nursing Intervention:
•Evaluate or continuously monitor degree of
joint inflammation or pain.
•Assess the level of intolerance and assist the
patient in activities she feels unable to perform.
•Assist with activity passive rangeof motion.
40
NURSING CARE PLAN con’t
Nursing Diagnosis: Hyperthermia related to inflammatory process
Nursing Intervention:
•Monitor vital sign
•Provide tepid sponge bath (if not
contraindicated)
•Promote client safety.
41
Health Education
Eats enough carbohydrate
Avoid or Limit alcohol
consumption
Limit meat and seafood intake
Avoid fatty foods
Avoid or Limit alcohol
consumption
Do the moderate daily exercise
Drink at least 6 to 8 glasses of
water each day.
Take the prescribed medication
and follow doctor`s order
42
ANY
QUESTIONS?
43
44

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Gout

  • 1. Ms. Sweta bijukshe lecturer ,BMI 1
  • 2. INTRODUCTION It is derived from the Latin word gutta, meaning "a drop" (of liquid). Earlier it was believed that an acute attack of the disease was the result of poison dropping into a joint Disease of the ‘KINGS’ (Rich foods have a higher concentration of protein. This could cause major problems for a person afflicted with gout) 2
  • 3. GOUT “The disease of kings" or “Rich man's disease".
  • 4. The King of Pain • Benjamin Franklin • Thomas Jefferson • Sir Isaac Newton • Charles Darwin 4
  • 5.  According to Brunner & Suddarth’s Text book of Medical –Surgical Nursing, gout is “A heterogeneous group of conditions related to a genetic defect of purine metabolism resulting in hyperuricemia. Over secretion of uric acid or a renal defect resulting in decreased excretion of uric acid, or a combination of both, occurs”(2010).  Characterized by hyperuricaemia ,acute arthritis, chronic to tophaceous arthritis & gouty nephropathy. DEFINITION 5
  • 6. 6
  • 7. 7
  • 8. 8
  • 9. INCIDENCE • Prevalence is reported to be about 2%. • Gout occurs more frequently in men than women over 40yrs M:F= (9:1) • The peak age of attack is 75 to 80 yrs • The incidence of gout become approximately equal b/t the sexes after 60yrs. 9
  • 11. 11
  • 12. 12
  • 13. Contd… Or causes may be discusses as : • Endogenous cause • Exogenous cause 13
  • 14. Endogenous cause Body build (associated with obesity) Cell breakdown (multiple myeloma, leukemia's, lymphomas, psoriasis Family History Reduced renal function 14
  • 15. Exogenous Dietary purines (liver, red meat, beans, peas, lentils) Alcohol Drugs (thiazides & loop diuretics, low dose salicylates Occupational lead exposure 15
  • 17.  Synovial fluid is a poor solvent for monosodium urate than plasma, urates in the joint fluid become supersaturated more easily ,particularly in the peripheral joints(ankles, toes) which have low temperature. With prolonged hyperuricemia,crystal & microtophi of urates develop in the synovial & in the joint cartilage.  Crystal are released to synovial fluid & they are chemo- attractant for neutrophils & macrophages which is the hallmark of acute attack.  Repeated attacks of acute arthritis lead eventually to chronic arthritis & formation of tophi in the inflamed synovial membranes & periarticular tissue ,as well as elsewhere.  In time, sever damage to the cartilage develops & the function of the joints is compromised. 17
  • 18. increased purine synthesis, decreased renal excretion A high dietary intake of purine, alcohol intake Increase uric acid in the blood (hyperuricemia) Deposition of uric acid into the joints GOUT 18
  • 19. 19
  • 20. 20
  • 21. 21
  • 22. Acute gouty arthritis  Severe pain, tenderness, warmth, redness and swelling .  Acute Gout attacks- needle-like pains on use of the joint affected.  First joint of the toes (metatarsophalangeal), 90% patients experience acute attacks in the great toe
  • 23. 23
  • 24. Cont… • Insteps - ankles, heels, knees, wrists, fingers, and elbows. • Commonly the first attacks - at night. • Systemic signs - leukocytosis, fever, and increase ESR • Early attacks tend to subside spontaneously over 3 to 10 days.
  • 25. INTERVAL GOUT • Complete remission of symptoms, • most patients experience a second attack from six months to two years later. • If they are untreated, the attacks will increase in frequency
  • 26. CHRONIC GOUT • Stage of Gout - reached after many years. Hard or gritty (tophaceous) deposits - joint and tendons. • Chronic joint symptoms - permanent erosive joint deformity appears. • Limitation of motion, often involving multiple joints of the hands, feet, or both.
  • 27. CHRONIC GOUT • Visible "tophi," deposits of monosodium urate -cartilage, synovial membranes, tendons, and soft tissues, after an average of about 12 years. • Tophi visible - margin of the ear lobe (pinna), fingers, hands, knees, and feet, and also the ulnar surface of the forearm. • Signs of renal involvement
  • 28.
  • 29.
  • 30. Diagnostic Test Medical History and Physical Examination Test to measure levels of uric acid in blood 30
  • 31. Diagnostic Test con’t Test to measure levels of uric acid in urine Extremity X-ray 31
  • 32. Diagnostic Test con’t Joint fluid analysis 32
  • 34. For acute gout ii.Colchicine: Lower the deposition of uric acid & interferes with leukocyte infiltration, thus reducing inflammation 34 i.NSAIDs: Indomethacine, Naproxen, Phenyl butazone iii. Corticosteroid :may be used in pt. who have no response to other therapy
  • 35. For chronic gout Probenecid: uricosuric agent; inhibits renal reabsorption of urates & increases the urinary excretion of uric acid Sulfinpyrazone: uric acid synthesis inhibitor 35 Allopurinol: uric acid synthesis inhibitor
  • 36. Surgical Treatment • If gout symptom have occurred off and on without treatment, uric acid crystals may have built up in the joints to form gritty, chalky nodules called tophi. 36
  • 37. Surgical Treatment con’t This tophi can cause infection pain, pressure, and deformed joints. Surgery will recommend by doing the excision to remove the tophi 37
  • 38. Complication Recurrent gout Advanced gout Kidney damage Joint damage Tophi Kidney stone 38
  • 39. NURSING CARE PLAN Nursing Diagnosis: Acute pain related to swelling joints Nursing Intervention: •The pain should be assessed on an ongoing basis using a scale of one to 10 to describe the severity. •Use cognitive therapy such as creative visualization to distract the patient from his pain. •Apply cold packs to inflamed joints to ease discomfort and reduce swelling. •Encourage the patient to perform techniques that promote rest and relaxation. 39
  • 40. NURSING CARE PLAN con’t Nursing Diagnosis: Activity Intolerance related to pain Nursing Intervention: •Evaluate or continuously monitor degree of joint inflammation or pain. •Assess the level of intolerance and assist the patient in activities she feels unable to perform. •Assist with activity passive rangeof motion. 40
  • 41. NURSING CARE PLAN con’t Nursing Diagnosis: Hyperthermia related to inflammatory process Nursing Intervention: •Monitor vital sign •Provide tepid sponge bath (if not contraindicated) •Promote client safety. 41
  • 42. Health Education Eats enough carbohydrate Avoid or Limit alcohol consumption Limit meat and seafood intake Avoid fatty foods Avoid or Limit alcohol consumption Do the moderate daily exercise Drink at least 6 to 8 glasses of water each day. Take the prescribed medication and follow doctor`s order 42
  • 44. 44