5. Trypanosoma brucei is parasitic protist
species that causes several disease for
human and animals.
There are 3 sub-species of T.brucei which
cause trypanosomiasis;
1- T.b.brucei
2- T.b.gambiense
3- T.b.rhodesiense
Approximately 16-18 million people are
currently infected, 50,000 of which die
each year.
6. It needs two host to complete its life
cycle
1- insect vector
2- mammalian host
It undergoes complex changes.
It also features a unique and notable
variable surface glycoprotein (VSG)
coat in order to avoid the host's
immune system
10. 1-1- AmastigoteAmastigote - Basal body anterior- Basal body anterior
of nucleus, with a short, essentiallyof nucleus, with a short, essentially
non-functional, flagellum.non-functional, flagellum.
2-2- PromastigotePromastigote - Basal body- Basal body
anterior of nucleus, with a longanterior of nucleus, with a long
detached flagellum.detached flagellum.
Trypanosoma life stages are:
11. 3-3- EpimastigoteEpimastigote - Basal- Basal
body anterior ofbody anterior of
nucleus, with a longnucleus, with a long
flagellum attached alongflagellum attached along
the cell body.the cell body.
4-4- TrypomastigoteTrypomastigote --
Basal body posterior ofBasal body posterior of
nucleus, with a longnucleus, with a long
flagellum attached alongflagellum attached along
the cell body.the cell body.
12. Infective stage for vertebrate isInfective stage for vertebrate is
metacyclic trypomastigotemetacyclic trypomastigote..
Infective stage for the invertebrate isInfective stage for the invertebrate is
trypomastigotetrypomastigote
