glycerol metabolism biochem

1. Glycerol Metabolism
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2. What is Glycerol Metabolism?

3. What is
Glycerol?
Glycerol is also called as glycerine or
glycerin. It is a simple polyol
compound.
It is a colorless, odorless, viscous liquid that is
sweet- tasting and non-toxic.
The glycerol backbone is found in those lipids
known as
glycerides.

4. Process:
During the
triacylglycerol
mobilization, one
molecule of
glycerol is
completely
hydrolyzed
TRIACYLGLYCEROL
MOLECULE

5. After entering the
bloodstream, the glycerol
travels to the liver or
kidneys, where the first
stage of glycerol
metabolism occurs.
At these locations, it is
converted to
dihydroxyacetone
phosphate, a
glycolysis/gluconeogenesis
intermediate.

6. The dihydroxyacetone
phosphate can be
converted to
pyruvate, then acetyl
CoA (Coenzyme A),
and finally carbon
dioxide, or it can be
used to form glucose.

7. Two (2) step ATP
consuming
process to
convert
GLYCEROL to
DHAP:
1.) Phosphorylation of
primary hydroxyl group of
glycerol
2.) Glycerol's alcohol group
(C2) is oxidized to a ketone.

8. 2 STEPS
1.) GLYCEROL WILL
BE CONVERTED TO
GLYCEROL
TRIPHOSPHATE WITH
THE HELP OF THE
ENZYME GLYCEROL
KINASE IN WHICH IT
WILL UTILIZE ONE
PHOSPHATE FROM
ATP WILL BE ADDED
ON THE THIRD
CARBON IN THE
GLYCEROL. SO, THE
ATP IS NOW ADP

9. 2. Conversion of glycerol phosphate to dihydroxyacetone phosphate with the help of
enzyme glycerol 3-phosphate dehydrogenase (removing hydrogen from glycerol 3-
phosphate) and the coenzyme that will aid this reaction is the oxidized form
nicotinamide adenine dinucleotide. that is how the glycerol has been converted to
dihydroxyacetone phosphate.

10. DIHYDROXY
ACETONE
PHOSPHATE
Is an intermediate in the glycolysis &
gluconeogenesis in which the dihydroxyacetone
phosphate can be converted to pyruvate and into
the acetyl CoA

11. GLYCEROL
M ETABOLISM
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