it may be helpful for those who wish to research in plasma medicine

1. A Review on Plasma in Medicine
Prepared by
Md. Sobur Hossain

2. Layout
Objectives
Introduction
Established plasma applications in the medical field
Scientific basis of modern plasma medicine
Atmospheric-pressure plasmas for medical purposes
Conclusion

3. Objectives
 The field of plasma applications for the treatment of medical
materials or devices is intensively researched and partially
well established for several years. Plasma medicine is an
innovative and emerging field combining plasma physics, life
science and clinical medicine.
 Plasma medicine in the sense of its actual definition as a new
field of research focuses on the use of plasma technology in
the treatment of living cells, tissues, and organs.
 This paper is an review on plasma that is used in medical
purposes and also about different types of plasma sources,
adapted plasma devices, plasma medicine, applications of
physical plasma etc.

4. Introduction
 Plasma is considered the fourth state of matter. The funny thing
about that is that as far as we know, plasmas are the most
common state of matter in the universe. They are even common
here on earth. The biggest chunk of plasma you will see is that
dear friend to all of us, the sun.
 The search for new and innovative fields of plasma application
for the new century resulted in new approaches solving unmet
problems by plasma technology.
 Plasma and medicine are interrelated in modern medical
technology, biotechnology and pharmacy.
 Plasma medicine is an emerging field that combines plasma
physics, life sciences and clinical medicine.
 Most of the research is in vitro and in animal models. Plasma
medicine means the direct application of cold atmospheric
plasma (CAP) on or in the human body for therapeutic
purposes.

5. Established plasma applications in the
medical field
 Oncology
 Wound healing
 Destroying MDR bacteria
 Treatment of pathogen-based skin diseases and skin
decontamination
 Treatment of chronic and infected wounds by eradicating
infection around the area and accelerating healing.
 Dentistry
 Ophthalmology
 epidemic control of bacteria
 Disinfection to the skin

6. Scientific basis of modern plasma
medicine

7. Scientific basis of modern plasma
medicine
Plasma influences
 specific detachment of cells from matrices as well as from
cell clusters
 cell migration
 cell proliferation and angiogenesis
 expression of cell surface proteins/cell adhesion molecules
(integrins, cadherins,)
 DNA integrity
 apoptosis induction, inactivation of cancer cells
 reversible cell membrane permeabilization (‘‘plasma
poration’’)
 blood coagulation by direct influence on the coagulation
cascade.

8. Atmospheric-pressure plasmas for
medical purposes
 it was well known that atmospheric-pressure plasma is
effective to inactivate microorganisms.
 Therefore, the first and, up to now, main focus of plasma
medical applications is in the field of dermatology, especially
for skin disinfection/antisepsis, treatment of infectious skin
diseases and wound healing.
 Plasma sources for direct or indirect plasma treatment were
distinguished, respectively:
Direct plasma treatment means that biological samples or
living tissue serve as one of the electrodes necessary for
plasma ignition.
In indirect plasma treatment, the electrodes are part of the
plasma-generating device, only. Thus, there is primarily no
electrical contact to the targeted structures.

9. Atmospheric-pressure plasmas for
medical purposes

10. Atmospheric-pressure plasmas for
medical purposes
 Some plasma sources devices are:
Barrier discharges (BDs)
plasma jets
corona discharges
dielectric barrier discharges (DBD)
Atmospheric pressure plasma jets (APP jets)
bullet type plasma jets (kINPen)
cold atmospheric Ar plasma jet

11. Conclusion
 The introduction of physical plasma into clinical practice is
not only a big challenge for interdisciplinary research at the
interface between plasma physics and life sciences, but also
an option to develop new therapeutic strategies for several of
today’s hard-to treat diseases such as chronic wounds or
MRSA.
 A responsible use of plasma sources which are designated
for biomedical applications is needed. A significant amount of
basic research has to be done now and in future to identify
potential medical indications and to estimate the risks of
plasma in use.

12. Conclusion
 A decisive condition for sustained success of clinical plasma
medicine is to have medical plasma sources which:
operate at atmospheric pressure to make possible
treatments of living objects,
are characterized by good manageability for operation at
open atmospheres,
operate stable with regard to reproducibility and reliability of
treatment results,
are well characterized with regard to plasma parameters and
‘‘macroscopic’’ characteristics to make possible process
control and monitoring,
are matched precisely to the specific application.

13. Thank You