zd

1. ZINC DEFICIENCY
MANIFESTATIONS

2. INTRODUCTION
• Zinc is an essential trace element
• Second most abundant trace element (next to iron) in the human body,
containing approximately 2–4 g
• Zinc is present in all body tissues
 60% is in skeletal muscle
 30% in bone
 4–6% in the skin

3. RDA

4. DIETARY SOURCES

5. PHYSIOLOGICAL FUNCTIONS OF ZINC

7. CAUSES OF ZINC DEFICIENCY
 HEREDITARY
• Defect in Zn transporter- Impaired absorption (Acrodermatitis Enteropathica)
 ACQUIRED
• Lack of nutrition
• Excessive alcohol intake
• Long term exposure to environmental toxins
• Malabsorption syndrome
• Chronic diseases e.G. Sickle cell anemia, wilson's disease, renal and liver diseases
• Tpn

9. CLINICAL FEATURES

11. ACRODERMATITIS ENTEROPATHICA
• Autosomal recessive
• Inherited defect in Zinc transporter
• Impaired intestinal absorption of Zinc
• Erythematous lesions - Vesiculobullous/ Pustular
lesions – Erythamatous plaques
• Nail changes : Brittle nails, Paronychia, Beau’s lines,
Leukonychia
Acral dermatitis
Alopecia Diarrhoea

13. TREATMENT
• Zinc supplementation – Zinc Sulphate
• Infants and children-0.5 to 1 mg/kg/day 1-3 divided doses
• Adults :- Malabsorption, diarrhoea, burns : 1-2mg/kg
• Acrodermatitis enteropathica / Wilson’s disease : 3 mg/kg/day
• Acrodermatitis Enteropathica : Lifelong zinc supplementation
• Acquired deficiency : Treat the underlying cause