Zinc is a chemical element with the symbol Zn and atomic number 30

1. Zn Presented by : Mzhda Salman

2. Zn
• is a microminerals which is required in amounts in less than
100mg/day. 30th element in the periodic table. its MW =
65.37, completely filled d orbitals. One oxidation state,
namely Zn2+ . Prefers tetrahedral complex formation. Is Not a
redox active metal. readily complexes with amino acids,
peptides, proteins and nucleotides. And it has affinity for
thiols, hydroxy groups & ligands with electron-rich nitrogen
donors.
• Total zinc content of body: 2g (60% in skeletal muscle, 30 % in
bones)
• Daily intake for adults and children: 10 mg/day
• Daily intake for lactation and pregnancy: 15-20 mg/day

3. Found In
• In nature Zinc makes up
about 0.0075% of Earth's
crust, making it the 24th
most abundant element.
• Dietary Sources :
• Relatively abundant
mineral found mostly in
shellfish, beef and other
red meats it also present
in Eggs, milk, poultry,
legumes & fish; Its 80%
lost to milling and hexa &
penta phosphates depress
absorption while High
meat diets enhance its
absorption .

4. Function
1. Zinc-containing enzymes
more than 70 enzymes they serve as Secondary & tertiary
protein structures and Metal stabilized active sites. Examples
of general types like Dehydrogenases, Phosphatases,
Peptidases, Kinases & deaminases.
2. Insulin
Zn important structurally and needed for insulin “stored”
in pancreas.
3.Cu/Zn Superoxide Dismutase
It acts as a cofactor , It contain general class of enzymes that
protect the body against oxidative damage.

5. Function
4. Nuclear transcription factors
also acting as a cofactor, Same protein structural
role forms “zinc-fingers”, “Zn-fingers” bind DNA, allow
different nuclear hormones to interact with DNA via different
DNA binding proteins.
5.It is also has a role in Cell Differentiation like in Thymidine
kinase activity and Creatine kinase activity.
6. Zinc plays a vital role in bringing the vitamin A from the liver to
the retina.

6. Zn Deficiency
• In Immune Function
Reduction in number of T and B lymphocytes.
• Zn influences Vitamin A metabolism
Night Blindness which is Hallmark deficiency sign for Vitamin
A ,Seen with Zn deficiency as well.
• In Excess accumulation within the cells it may disrupt
functions of biological molecules such as Protein, enzymes,
DNA and Leads to toxic consequences.
• Acute excessive intakes will be Local irritant to tissues and
membranes like GI distress, nausea, vomiting, abdominal
cramps, diarrhea.

7. Zn Deficiency
• It will lead to Growth retardation, Delayed sexual maturation
& impotence, & hypospermia & alopecia.
• Also it will lead to Behavioral changes, Impaired taste
(hypoguesia), Delayed healing of wounds, burns, Impaired
appetite & food intake and Eye lesions including
photophobia & lack of dark adaptation.
• Deficiency During Pregnancy
• It is founded that Zn deficient rats failed to conceive and Zn
deficient During Pregnancy will lead Abnormalities of
blastocyst development, and it will lead to high incidence of
abnormalities like Deformities of brain, skull, limbs, eyes,
heart, lungs.