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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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expulsion of blood from the penis. Erection can be effortlessly
accomplished by utilizing Zhewitra 40mg.
The amount to take?
Continuously take the medication measurements as recommended by
the specialist as it were. Never show signs of change the
3. measurements, begin, or quit utilizing the medication without
doctor’s consent. Measurement may rely upon a scope of elements
like age, sex, sedate hypersensitivities, or earnestness of the condition
among a few different components. Continuously entire the dosage.
How to Use it?
Swallow the tablet with one glass brimming with water. Try not to
break the tablet. Take the medication precisely as coordinated. This
medication ought to be joined with all around adjusted calorie
controlled eating routine that is rich in leafy foods.
Take the tablet in the meantime every day, to abstain from overlooking
the measurement. This ought to wind up a propensity for you to take
the tablet until the point that the specialist instructs you to stop the
medication.
Take the medication as long as the specialist endorses you to do. Try
not to quit taking the solution without the doctor’s guidance.
What are the reactions?
Tell your specialist as quickly as time permits in the event that you see
any of the accompanying:
Cerebral pains, Persistent sickness, Mood changes, Vomiting, Painful
erection or a delayed erection that continues for in excess of 4
hours(that can be harming for penis) and so forth.
4. In above cases you should go for prompt therapeutic help. Try not to
get frightened by the rundown. You may/may not encounter every one
of them. Tell your specialist promptly in the above circumstances.
In what capacity should Vardenafil be put away?
You should store your Vardenafil tablets beneath 25°C out of a cool
dry place.
Who can utilize Zhewitra 40 mg?
Zhewitra 40 mg is intended for men as it were.
Is Zhewitra 40 mg for ladies and kids as well?
There are more prominent odds of wellbeing dangers if the medication
is taken by ladies or kids.
Who ought not utilize Zhewitra 40 mg?
Men experiencing fundamental restorative conditions ought not utilize
this solution. Medical issues that deflect the utilization of Zhewitra 40
mg tranquilize are, hypertension, hypotension, diabetes, draining
scatters, seizures, eye issue, peyronie ailment, cardiovascular issues,
strokes, angina, ulcer, sickle cell paleness, priapism et cetera.
5. Is Zhewitra 40 mg really enhances sexual life?
With Zhewitra 40 mg you don't need to stress over anything about
suggestive issues. This medicine works quickly on sexual life and takes it
to a next more elevated amount.
Does the medication have any impact on the sexual want?
Zhewitra 40 mg is no chance identified with sexual want the extent that
its working is concerned. Neither the medication neither enhances nor
diminishes sexual want.
Is sexual want important for influencing the medication to work?
The medication does not have affect on sexual want straightforwardly,
but rather without the nearness of incitement it can't work. Sexual
excitement is noteworthy for Zhewitra 40 mg work proficiently.
What is the fitting measurements of Zhewitra 40 mg?
Vardenafil comes as a tablet and a quickly breaking down (disintegrates
in the mouth and is gulped without water) tablet to take by mouth. It is
typically taken as required, with or without sustenance, a hour prior
sexual movement. Vardenafil as a rule ought not be taken more
regularly than once like clockwork. In the event that you have certain
wellbeing conditions or are taking sure meds, your specialist may
instruct you to take vardenafil less frequently. Take after the bearings
on your medicine mark deliberately, and ask your specialist or drug
6. specialist to clarify any part you don't get it. Take vardenafil precisely as
coordinated. Try not to take pretty much of it or take it more frequently
than recommended by your specialist.
In the event that you are taking the quickly deteriorating tablet, check
the blisterpack before you take your first dosage. Try not to utilize any
of the pharmaceutical from the pack if any of the rankles are torn,
broken, or don't contain tablets. Take after the bundle bearings to
expel the tablet from the rankle bundle. Try not to attempt to push the
tablet through the thwart. After you expel the tablet from the rankle
bundle, promptly put it on your tongue and close your mouth. The
tablet will rapidly break down. Try not to take the quickly breaking
down tablet with water or different fluids.
Your specialist will most likely begin you on a normal dosage of
vardenafil tablets and increment or reduction your measurements
relying upon your reaction to the solution. On the off chance that you
are taking the quickly breaking down tablets, your specialist won't have
the capacity to modify your measurement in light of the fact that the
quickly deteriorating tablets are just accessible in one quality. On the
off chance that you require a higher or lower dosage, your specialist
may recommend the customary tablets. Tell your specialist if vardenafil
isn't functioning admirably or on the off chance that you are
encountering reactions.
7. Vardenafil quickly crumbling tablets can't be substituted for vardenafil
tablets. Make sure that you get just the kind of vardenafil that was
endorsed by your specialist. Inquire as to whether you have any
inquiries regarding the kind of vardenafil you were given.
Other essential data
Keep all meetings with your specialist.
Try not to let any other individual take your prescription. Ask your drug
specialist any inquiries you have about refilling your medicine.
It is imperative for you to keep a composed rundown of the greater
part of the solution and nonprescription (over-the-counter) drugs you
are taking, and additionally any items, for example, vitamins, minerals,
or other dietary supplements. You ought to carry this rundown with
you each time you visit a specialist or on the off chance that you are
admitted to a healing facility. It is additionally essential data to convey
with you if there should be an occurrence of crises.
What happens if the measurements is missed?
Zhewitra 40 mg isn't for standard utilize. The endorsed measurement is
just required to be taken when crave having intercourse. Generally
don't take the medication.
What happens if overdose is taken?
8. On the off chance that taken an overdose, instantly call your specialist.
In the event that surpassed the measurement of Zhewitra 40 mg can
need to confront extreme symptoms. Never take the burrowed more
than proposed.
What do I do if Zhewitra 40 mg does not work in the main
occurrence?
It isn't basic that everybody will encounter late outcomes, yet Zhewitra
40 mg can once in a while take minimal long in demonstrating comes
about. In any case, until the point that that you have to keep
persistence and continue following measurements guidelines as
recommended.
What is the utilization system of the medication?
Just water ought to be utilized for gulping pill. Gulping down pill as an
entire is essential. On the off chance that the pill is bitten or broken, it
can take longer in giving erections. Utilization of different answers for
gulping pill postpones comes about. The medication does not
disintegrate as fast in the blood as it does when taken with water. Take
pill with water as it were. The medication should be taken 30 minutes
ahead of time to the intercourse. Promptly after the take-up erections
can't be normal. Thus, take ahead of time and sit tight for quite a while.
Just a single pill is suggested for one day. Surpassing the pill number
can make medical issues. For taking next time men need to sit tight for
at any rate for 24 hours. Try not to break these guidelines.
9. Could Zhewitra 40 mg be gone up against discharge stomach?
On the off chance that expecting fast outcomes from your medication,
take it on exhaust stomach. Zhewitra 40 mg ought to dependably be
taken like this as it were. The medication can be taken in the wake of
eating nourishment additionally yet light. Taking the medication in the
wake of eating substantial greasy and slick sustenances
straightforwardly impacts its working outcome time.
What are the evil impacts of Zhewitra 40 mg on wellbeing?
Zhewitra 40 mg demonstrates some regular manifestations after the
admission. Be that as it may, they keep going for a brief span. Sit tight
for them to vanish on claim without taking treatment. Regular side
effects of the medication are-migraine, energy, sickness, nasal clog,
back agony, light affectability, and so on. Therapeutic guide is taken if
basic reactions keep going for long time.
Is smoking safe in the wake of taking Zhewitra 40 mg?
Try not to smoke if taking Zhewitra 40 mg.
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