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Tadalafil is used to treat erectile dysfunction, a condition in wherein a man cannot get, or keep, a hard erect penis suitable for sexual activity. Dapoxetine Hydrochloride is a treatment for premature ejaculation (PE) in men 18 to 64 years old who have ejaculate within 2 minutes following penetration and before the man wishes to as well as marked personal distress and interpersonal difficulty as a result of premature ejaculation and poor control over ejaculation.
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Buy Tadalista 5mg dose is 5 to 20 mg orally once a day, as needed, prior to sexual activity based on individual efficacy and tolerability. For daily use for Erectile Dysfunction and Benign Prostatic Hyperplasia (BPH): Use 5 mg orally once a day at the same time, without regard to timing of sexual activity. Adult Dose for Pulmonary Hypertension: Use 40 mg orally once a day.
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i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
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STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
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1. Tadalista 40 mg (Tadalafil)
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Tadalista is a bland type of Tadalafil. The medication's principle
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What is Tadalista 40 mg ?
It treats ED or erectile brokenness. Your specialist may likewise
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Who ought not take this medication?
Regardless of whether you have ED, you may not take this medication,
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Instructions to take Tadalista 40 mg
Tadalista 40 mg works best when taken one half hour before sexual
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Regardless of what sort of prescription it is that you will utilize, whether
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mg.
For the most part, Tadalista 40 mg can be taken by mouth with or
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3. take this medicine every day, at that point your specialist may
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of the day - as the impact may keep going for up to 36 hours. Then
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that a higher measurement would be prescribed.
It is best to take Tadalista 40 mg no less than 30 minutes before the
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Tadalista 40 mg insurances
Your specialist will need to take your total medicinal history before
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Tadalista 40 mg contraindications
Your specialist should think about all medicine and non-physician
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can collaborate with Tadalista 40 mg. Check with your specialist before
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Tadalista 40 mg can't be taken with different prescriptions used to treat
erection issues. Your specialist can enable you to change your
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wellbeing history.
Tadalista 40 mg Special Information
Tadalista isn't demonstrated for use in ladies.
Breaking point mixed drinks.
As Tadalista may cause wooziness, don't drive, or play out any
movement that requires sharpness.
Tadalista Drug Interactions
At the point when Tadalista is taken with specific medications, its
belongings could be modified. Tadalista can interface with anti-
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seizure pharmaceuticals. Along these lines, previously taking Tadalista,
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Clarithromycin
Clotrimazole
6. The reactions of Tadalista 40 mg are normally minor. Common
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leave following a couple of hours. At times, back agony or muscle
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measurement of Tadalista 40 mg. By and large, it will leave inside 48
hours. In the event that you are pestered by the symptoms if Tadalista
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