Stress has significant negative impacts on both individuals and organizations. It is estimated to cost US employers $300 billion annually in healthcare costs and missed work. Most people regularly experience physical and psychological symptoms of stress, and many cite work as a leading cause. Unmanaged stress can weaken the body and increase risks of various health issues. It also impacts brain function and cognitive performance. Neuroscience research shows the brain can rewire itself through changes in thoughts and behaviors, offering hope for managing stress. Leaders play a key role, as their actions are a major workplace stressor, but creating a supportive environment where stress can be openly discussed enables sustainable change for both individuals and organizations.