Retailers can achieve significant supply chain cost savings and improve customer service levels by optimizing their supply chain design. Modeling the end-to-end supply chain and analyzing strategies like omni-channel fulfillment, supply chain segmentation, right-sizing inventory, and product flow optimization can identify opportunities to lower costs while maintaining service levels. Implementing these strategies helped one retailer reduce supply chain costs by 10-20% and saved another retailer millions of dollars annually in supply chain costs.